FASEB Conference for Skeletal muscle satellite and stem cells

描述(由申请人提供)：本申请寻求部分支持即将到来的美国实验生物学学会联合会(FASE B)会议，题为骨骼肌卫星和干细胞，将于2010年7月18-23日在亚利桑那州的Carefree举行。本次会议的总体目标是强调与肌源性干细胞和祖细胞群体(如卫星细胞)的调控机制有关的最新进展，以及它们在发育、再生、衰老和肌病状态中的作用。这将是第五次聚焦于卫星细胞/干细胞和肌肉再生的会议。从第一次会议到第四次会议的参与率增加，表明需要专门讨论卫星和干细胞问题的会议。从前四次会议的成功中可以清楚地看出，这一专题引起了高度关注，而这次会议是唯一一次直接讨论肌肉、卫星和干细胞群体问题的会议。这次多学科会议的每两年举行一次，有助于提出新的未公布的数据，这些数据引起了大量讨论，并促进了协作互动。本次论坛将侧重于鉴定成人骨骼肌中的祖细胞/干细胞群体，特别关注它们在发育、肥大、再生、衰老和疾病中的作用。讨论将针对基于细胞的疗法的平台。这次会议的内容包括：卫星细胞的发育起源、卫星细胞的异质性、卫星细胞的静止和激活、肌源性谱系进展的分子控制、肌肉干细胞生态位、卫星细胞自我更新、肌肉干细胞的多能性、肌肉前体细胞的分化和融合、疾病和萎缩的细胞治疗、肌肉干细胞的老化以及生长和肥大中的肌肉前体细胞。此外，还将举办干细胞治疗研讨会。重要的是，这次会议的与会者将代表跨学科小组，他们将为该领域的最新发现提供全面的分析和整合。这次会议将进一步促进协作互动，试图促进未来针对治疗和治愈肌病患者的进展和翻译倡议。

DESCRIPTION (provided by applicant): This application seeks partial support for the upcoming Federation of American Societies of Experimental Biology (FASEB) conference entitled, Skeletal muscle satellite and stem cells, that will be held on July 18 - 23, 2010 in Carefree, AZ. The overall objective of this meeting is to highlight recent advances pertaining to the regulatory mechanisms of myogenic stem cell and progenitor cell populations (such as satellite cells) and their role in development, regeneration, aging and myopathic states. This will be the fifth conference focused on satellite cells/stem cells and muscle regeneration. The increased participation from the first to the fourth meetings has demonstrated the need for a conference dedicated to satellite and stem cells. It is clear from the successes of the previous four meetings that this topic is of high interest and this meeting represents the only conference that directly addresses muscle satellite and stem cell populations. The biennial timing of this multidisciplinary conference has facilitated the presentation of new unpublished data that has generated considerable discussion and promoted collaborative interactions. This forum will focus on the identification of the progenitor/stem cell populations that are resident in adult skeletal muscle with a particular focus on their participation in development, hypertrophy, regeneration, aging and disease. Discussion will be directed toward platforms for cell based therapies. The sessions of this conference include: the developmental origins of satellite cells, satellite cell heterogeneity, satellite cell quiescence and activation, the molecular control of myogenic lineage progression, the muscle stem cell niche, satellite cell self-renewal, pluripotentiality of muscle stem cells, muscle progenitor cell differentiation and fusion, cellular therapies in disease and atrophy, the aging of muscle stem cells, and muscle progenitors in growth and hypertrophy. In addition, there will be a stem cell therapy workshop. Importantly, the participants of this conference will represent interdisciplinary groups that will provide a comprehensive analysis and integration of recent discoveries for the field. The conference will further promote collaborative interactions in an attempt to promote future advancements and translational initiatives directed toward the treatment and cure of patients with myopathic diseases.