CVS SYMPOSIUM: PHOTONS AND NEURONS

CVS 研讨会：光子和神经元

• 批准号: 7913567
• 负责人: DAVID R WILLIAMS
• 金额: $ 4.17万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7913567
• 关键词: Award; Behavior; Blood flow; Brain; Cells; Cerebral cortex; Code; Engineering; Fellowship; Functional Magnetic Resonance Imaging; Goals; Image; Individual; Light; Microelectrodes; Molecular; Molecular Biology; Motivation; Neurobiology; Neurons; Neurosciences; Optics; Organism; Photons; Population; Primates; Prize; Records; Research Personnel; Resolution; Retina; Sampling; Schedule; Scientist; Sensory; Signal Transduction; Solutions; Structure; Techniques; Time; Travel; Universities; Work; awake; graduate student; imaging modality; interdisciplinary approach; interest; meetings; minimally invasive; neural circuit; neurophysiology; optical imaging; posters; public health relevance; relating to nervous system; symposium; vision science

DESCRIPTION (provided by applicant): A fundamental goal of neuroscience is to understand how neural circuitry carries out the computations that transform raw sensory signals into behavior. Current understanding is limited by available techniques for recording neural activity in awake, behaving organisms. At one end of the range of spatial scales, microelectrode arrays provide excellent temporal resolution of single neuron activity, but can only sparsely sample the local neuronal population. At the other end, functional magnetic resonance imaging has poor resolution in both space and time, and records neuronal activity only indirectly through blood flow. Optical imaging promises to revolutionize neuroscience by bridging this gap and offer minimally-invasive, direct recording of neural activity at single cell resolution in the intact working brain. Optical imaging of neural activity, however, has yet to deliver the ultimate prize of recording the activity of many individual neurons in real time throughout the depth of a brain structure such as the cerebral cortex. Achieving such a goal will require the coordinated effort of experts from disparate backgrounds, including neuroscientists, optical engineers, biochemists and molecular biologists. The obvious need to bring such experts together in dialogue is the central motivation for the 27th Symposium of the Center for Visual Science (CVS), entitled "Photons and Neurons", scheduled for June 4th- 6th, 2010 at the University of Rochester. The goal is to bring together scientists who develop and use imaging methods and provide a platform to exchange ideas, identify pressing neurobiological questions, discuss current limitations, and develop possible solutions. Individual sessions will cover the following topics: (1,4) Imaging CNS circuits, (2) Advances in Optical imaging, (3) Imaging the retina, (5) Controlling neurons with light. We expect that the Symposium will attract researchers representing multidisciplinary approaches ranging from neural coding and primate neurophysiology to optical engineering and molecular biology. We are particularly interested in attracting younger neuroscientists and optical engineers. To that end, we plan to award ten travel fellowships to graduate students interested in attending the meeting and provide them with an opportunity to present their work in a poster session. PUBLIC HEALTH RELEVANCE: Optical imaging of neural activity has yet to deliver the ultimate prize of recording the activity of many individual neurons in real time throughout the depth of a brain structure such as the cerebral cortex. Achieving such a goal will require the coordinated effort of experts from disparate backgrounds, including neuroscientists, optical engineers, biochemists and molecular biologists. The obvious need to bring such experts together in dialogue is the central motivation for the 27th Symposium of the Center for Visual Science (CVS), entitled "Photons and Neurons."

描述（由申请人提供）：神经科学的一个基本目标是了解神经回路如何进行将原始感觉信号转化为行为的计算。当前的理解受到可用技术记录醒着的神经活动的可用技术，行为有机体。在空间尺度范围的一端，微电极阵列提供了单个神经元活性的出色时间分辨率，但只能稀少地对局部神经元种群进行采样。在另一端，功能性磁共振成像在空间和时间上的分辨率较差，并且仅通过血流间接记录神经元活动。光学成像有望通过弥合这一差距来彻底改变神经科学，并在完整的工作大脑中提供微不足道的直接记录神经活动。然而，神经活动的光学成像尚未获得最终的奖励，即在整个大脑结构（例如大脑皮层）的整个深度中记录许多单个神经元的活性。实现这样的目标将需要来自不同背景的专家的协调，包括神经科学家，光学工程师，生物化学家和分子生物学家。显然需要将此类专家进行对话组合在一起，这是视觉科学中心（CVS）第27届研讨会的核心动机，该专家定于2010年6月4日至6日在罗切斯特大学举行。目的是将开发和使用成像方法的科学家汇集在一起​​，并提供一个平台来交换思想，确定紧迫的神经生物学问题，讨论当前的局限性并开发可能的解决方案。各个会话将涵盖以下主题：（1,4）成像CNS电路，（2）光学成像的进展，（3）对视网膜进行成像，（5）用光控制神经元。我们预计，研讨会将吸引代表从神经编码和灵长类神经生理学到光学工程和分子生物学的多学科方法的研究人员。我们特别有兴趣吸引年轻的神经科学家和光学工程师。为此，我们计划为有兴趣参加会议的研究生授予十项旅行奖学金，并为他们提供在海报会议上介绍其工作的机会。 公共卫生相关性：神经活动的光学成像尚未获得最终的奖项，即在整个大脑结构的深度（例如大脑皮层）中实时记录许多单个神经元的活动。实现这样的目标将需要来自不同背景的专家的协调，包括神经科学家，光学工程师，生物化学家和分子生物学家。将这些专家融合在一起的显然需要是视觉科学中心（CVS）（名为“光子和神经元”的第27届专题讨论会的中心动机。