2010 Carotenoids Gordon Research Conference

描述（由申请人提供）：摘要：本提案要求部分支持将于2010年1月17日至22日在加州文图拉举行的戈登研究会议系列的一部分类胡萝卜素国际会议。会议的广泛和长期目标是增加我们对类胡萝卜素科学的理解，目的是应用科学知识最终改善人类健康。本次会议的具体目标是召集大约45位发言人，他们代表了从多学科角度来看类胡萝卜素研究的关键领域，共有135名与会者参加为期五天的会议。该计划将有九个会议，广泛解决类胡萝卜素研究中的当前问题，包括以下内容：（一）基因组学/建模/系统生物学;（二）生物合成和调节;（三）光合作用;（四）维生素原A类胡萝卜素的代谢工程;（五）类胡萝卜素运输和代谢/脱辅基类胡萝卜素;（六）类胡萝卜素的生物作用;（七）眼睛健康中的类胡萝卜素;（八）类胡萝卜素和氧化：慢性病预防;（九）基调，选定的简短谈话。此外，两次晚间海报会议将使所有与会者都能对这些主题作出贡献。这一应用的重要性在于，戈登类胡萝卜素研究会议（每3年举行一次）是推动国际类胡萝卜素研究人员研究的一系列会议的基础组成部分。本申请的健康相关性在于阐明如何最好地利用类胡萝卜素科学来影响已知与类胡萝卜素摄入不足有关的疾病（例如，提高食物供应中维生素A原的含量，以在全球预防维生素A缺乏和由此导致的失明），以及使用新的方法来阐明类胡萝卜素在预防慢性疾病，特别是与年龄有关的眼病以及癌症和其他衰老疾病中的潜在作用。 公共卫生相关性：叙述：类胡萝卜素对国内和国际公共卫生至关重要。维生素A缺乏是世界范围内发病率和死亡率的主要原因，特别是影响儿童（例如，干眼症）。现在可以对主食进行代谢改造，提供维生素原A类胡萝卜素，以改善世界上数百万最贫穷儿童的健康。非维生素原A类胡萝卜素似乎对人类健康也很重要;例如，最新的研究表明，某些类胡萝卜素可能在预防老年性黄斑变性中发挥作用，老年性黄斑变性是65岁以上美国人失明的主要原因。

DESCRIPTION (provided by applicant): Abstract: This proposal requests partial support for an international meeting on Carotenoids as part of the Gordon Research Conference series to be held in Ventura, California January 17-22, 2010. The broad and long term goal of the conference is to increase our understanding of the science of carotenoids with the goal of applying the scientific knowledge to ultimately improve human health. The specific aims of this meeting will be to convene approximately 45 speakers who represent critical areas of carotenoid research from a multidisciplinary perspective with a total of 135 participants for a five day conference. The program will have nine sessions that broadly address current issues in carotenoid research, including the following: (i) genomics/modeling/systems biology; (ii) biosynthesis and regulation; (iii) photosynthesis; (iv) metabolic engineering of provitamin A carotenoids; (v) carotenoid transport and metabolism/apocarotenoids; (vi) biological actions of carotenoids; (vii) carotenoids in eye health; (viii) carotenoids and oxidation: chronic disease prevention; (ix) keynote, selected short talks. In addition, two evening poster sessions will permit all participants to contribute to these topics. The significance of this application is that the Gordon Research Conference on Carotenoids (held every 3 years) is a foundational component of the series of conferences that propel research in the international community of carotenoid researchers. The health relatedness of this application is in clarifying how best to use carotenoid science to impact diseases known to be related to inadequate carotenoid intake (e.g., improving the provitamin A content of the food supply for the global prevention of vitamin A deficiency and resulting blindness) as well as to use new methodologies to elucidate the potential role of carotenoids in the prevention of chronic disease, especially age-related eye disease but also cancer and other diseases of aging. PUBLIC HEALTH RELEVANCE: Narrative: Carotenoids are critical for public health both domestically and internationally. Vitamin A deficiency is a leading cause of morbidity and mortality worldwide, especially affecting children (e.g., xeropthalmia). Staple foods can now be metabolically engineered to provide provitamin A carotenoids to improve the health of millions of the world's poorest children. Non-provitamin A carotenoids also appear to be important in human health; e.g., cutting edge research suggests certain carotenoids may play a role in the prevention of age- related macular degeneration, the leading cause of blindness in Americans over age 65.