MIDARP at CCNY

CCNY 的 MIDARP

• 批准号: 7753147
• 负责人: EITAN FRIEDMAN
• 金额: $ 42.99万
• 依托单位: CITY COLLEGE OF NEW YORK
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7753147
• 关键词: American; Area; Biochemistry; Biological; Biological Sciences; Biology; Biomedical Engineering; Biophysics; Brain Diseases; CCL7 gene; Career Choice; Cell Nucleus; Chemistry; Cities; Cocaine; Collaborations; Commit; Core Facility; Dedications; Development; Dopamine D1 Receptor; Drug abuse; Education; Educational workshop; Environment; Extramural Activities; Faculty; Financial Support; Fostering; Functional disorder; Funding; Future; Goals; Immigrant; Individual; Institution; Investigation; Laboratories; Leadership; Location; MAP Kinase Gene; Measures; Mentors; Minority; Mission; Molecular; Molecular Biology; N-Methyl-D-Aspartate Receptors; National Institute of Drug Abuse; Neurobiology; Neurons; New York; Participant; Perinatal Exposure; Pharmacology; Physiology; Population; Positioning Attribute; Productivity; Program Evaluation; Psychology; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Schools; Science; Scientist; Secure; Social Sciences; Solid; Structure; Students; Training; Training Programs; Training Support; Transcend; Underrepresented Minority; United States National Institutes of Health; Universities; addiction; base; career; career development; cocaine exposure; college; design; drug of abuse; experience; graduate student; improved; in utero; interest; medical schools; neurochemistry; operation; prenatal; programs; research and development; science education; social; structural biology; success; symposium

DESCRIPTION (provided by applicant): CCNY, the science flagship of the CUNY is heavily (75%) involved in educating students from underrepresented minority populations. It is our goal to develop a program at CCNY that draws on existing strengths and focuses and promotes investigations on drug abuse. Our clear aim is to encourage entry of young minority undergraduates and graduate scholars to a career in drug abuse research. The program is thematically focused on the long-term sequel of in utero exposure to cocaine. The neurobiological investigations encompass research on molecular, cellular, and neurochemical effects of exposure to cocaine. The program includes active research faculty, educators specializing in drug abuse graduate and undergraduate research students who share interest in the neurobiology of stimulants and in understanding addiction as a brain disease. The aims of the application are to enhance the breadth of research at CCNY that focuses on the neurobiology of drugs of abuse. The program is also designed to develop individual research projects and to stimulate interest of other faculty and students in research on drug abuse. The overall aim of this program is to facilitate the career development of minority undergraduate and graduate students who will mature into independent investigators of the future. The specific projects proposed are: 1. MAPK in in utero cocaine-induced abnormal neuron differentiation. 2. GSK3beta in prenatal cocaine-induced D1 dopamine receptor dysfunction and dendritic elongation. 3. Prenatal cocaine alterations of NMDA receptor assembly. 4. Protection against the glutametergic effects of in utero cocaine. The PI is an established drug abuse researcher with over 30 years experience. He and other senior faculty will serve as mentors to junior scientists. As a group the faculty are extremely experienced in attracting and mentoring young minority scholars to research. The Institution has committed significant financial support to help secure the success of this program that aims to enhance interest in minorities in the choice of career in drug abuse research.

描述（由申请人提供）：

项目成果

Prenatal cocaine exposure increases synaptic localization of a neuronal RasGEF, GRASP-1 via hyperphosphorylation of AMPAR anchoring protein, GRIP.

• DOI: 10.1371/journal.pone.0025019
• 发表时间: 2011
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Bakshi K;Kosciuk M;Nagele RG;Friedman E;Wang HY
• 通讯作者: Wang HY

Flurbiprofen benzyl nitrate (NBS-242) inhibits the growth of A-431 human epidermoid carcinoma cells and targets β-catenin.

• DOI: 10.2147/dddt.s43771
• 发表时间: 2013
• 期刊: Drug design, development and therapy
• 作者: Nath N;Liu X;Jacobs L;Kashfi K
• 通讯作者: Kashfi K

Synthesis and biological activity of NOSH-naproxen (AVT-219) and NOSH-sulindac (AVT-18A) as potent anti-inflammatory agents with chemotherapeutic potential.

• DOI: 10.1039/c3md00185g
• 发表时间: 2013
• 期刊: MedChemComm
• 作者: Kodela R;Chattopadhyay M;Kashfi K
• 通讯作者: Kashfi K

Prenatal cocaine exposure uncouples mGluR1 from Homer1 and Gq Proteins.

产前接触可卡因会使 mGluR1 与 Homer1 和 Gq 蛋白解偶联。

• DOI: 10.1371/journal.pone.0091671
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Bakshi,Kalindi;Parihar,Raminder;Goswami,SatindraK;Walsh,Melissa;Friedman,Eitan;Wang,Hoau-Yan
• 通讯作者: Wang,Hoau-Yan

Cocaine challenge enhances release of neuroprotective amino acid taurine in the striatum of chronic cocaine treated rats: a microdialysis study.

可卡因激发可增强慢性可卡因治疗大鼠纹状体中神经保护氨基酸牛磺酸的释放：一项微透析研究。

• DOI: 10.1016/j.brainresbull.2008.12.014
• 发表时间: 2009
• 期刊: Brain research bulletin
• 影响因子: 3.8
• 作者: Yablonsky-Alter,Elena;Agovic,MervanS;Gashi,Eleonora;Lidsky,TheodoreI;Friedman,Eitan;Banerjee,ShaileshP
• 通讯作者: Banerjee,ShaileshP