MIDARP at CCNY

描述（由申请人提供）： CCNY是纽约市立大学的科学旗舰，主要（75%）参与教育来自代表性不足的少数民族人口的学生。我们的目标是在CCNY制定一个计划，利用现有的优势，重点和促进对药物滥用的调查。我们的明确目标是鼓励年轻的少数民族本科生和研究生学者进入药物滥用研究领域。该计划的主题是集中在子宫内接触可卡因的长期后果。神经生物学研究包括对接触可卡因的分子、细胞和神经化学效应的研究。该计划包括积极的研究教师，教育工作者专门从事药物滥用研究生和本科研究生谁分享兴趣的兴奋剂的神经生物学和理解成瘾作为一种大脑疾病。该申请的目的是提高CCNY的研究广度，重点是滥用药物的神经生物学。该计划还旨在开发个人研究项目，并激发其他教师和学生对药物滥用研究的兴趣。该计划的总体目标是促进少数族裔本科生和研究生的职业发展，他们将成长为未来的独立调查人员。提出的具体项目有：1. MAPK在子宫内可卡因诱导的异常神经元分化中的作用2. GSK3 β在产前可卡因诱导的D1多巴胺受体功能障碍和树突延长中的作用3.产前可卡因改变NMDA受体组装。4.保护子宫内可卡因对子宫内膜的影响。PI是一位具有30多年经验的成熟药物滥用研究人员。他和其他高级教员将担任初级科学家的导师。作为一个群体，教师在吸引和指导年轻的少数民族学者进行研究方面经验丰富。该机构已承诺提供大量财政支持，以帮助确保这一计划的成功，该计划旨在提高少数民族在药物滥用研究职业选择方面的兴趣。

DESCRIPTION (provided by applicant): CCNY, the science flagship of the CUNY is heavily (75%) involved in educating students from underrepresented minority populations. It is our goal to develop a program at CCNY that draws on existing strengths and focuses and promotes investigations on drug abuse. Our clear aim is to encourage entry of young minority undergraduates and graduate scholars to a career in drug abuse research. The program is thematically focused on the long-term sequel of in utero exposure to cocaine. The neurobiological investigations encompass research on molecular, cellular, and neurochemical effects of exposure to cocaine. The program includes active research faculty, educators specializing in drug abuse graduate and undergraduate research students who share interest in the neurobiology of stimulants and in understanding addiction as a brain disease. The aims of the application are to enhance the breadth of research at CCNY that focuses on the neurobiology of drugs of abuse. The program is also designed to develop individual research projects and to stimulate interest of other faculty and students in research on drug abuse. The overall aim of this program is to facilitate the career development of minority undergraduate and graduate students who will mature into independent investigators of the future. The specific projects proposed are: 1. MAPK in in utero cocaine-induced abnormal neuron differentiation. 2. GSK3beta in prenatal cocaine-induced D1 dopamine receptor dysfunction and dendritic elongation. 3. Prenatal cocaine alterations of NMDA receptor assembly. 4. Protection against the glutametergic effects of in utero cocaine. The PI is an established drug abuse researcher with over 30 years experience. He and other senior faculty will serve as mentors to junior scientists. As a group the faculty are extremely experienced in attracting and mentoring young minority scholars to research. The Institution has committed significant financial support to help secure the success of this program that aims to enhance interest in minorities in the choice of career in drug abuse research.