Ancillary Study 1
Ancillary Study 1
批准号:
7934327
负责人:
Joseph Zabner
金额:
$120.54万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-04-01 至 2013-03-31
关键词:
AcuteAdultAffectAirAllelesAncillary StudyAnti-Bacterial AgentsAntibioticsAreaBacteriaC14 isotopeCarbohydratesCarbonChronicChronic BronchitisClinicalClinical ResearchCystic Fibrosis Transmembrane Conductance RegulatorDataDefectDental cariesDiseaseDoseEarly treatmentEpithelialEpitheliumEquilibriumEvaluationFamily suidaeFigs - dietaryGenotypeGlucoseGoalsGrantGrowthHaemophilus influenzaeHeightHumanIn VitroIncidenceInfectionInfection preventionLifeLiquid substanceLobeLongitudinal StudiesLungMannitolMeasurementMeasuresMediatingMethodsMicrobiologyMorphologyMucociliary ClearanceNatural ImmunityNeonatalNewborn InfantOrganismOsmolar ConcentrationOtitis MediaPermeabilityPhenotypeProceduresPropertyPseudomonas aeruginosaRadioactive TracersReaction TimeRelative (related person)ReportingResearch DesignRespiratory FailureSalineSamplingShockSodium ChlorideSolutionsSourceSpecimenStaphylococcus aureusSurfaceSweetening AgentsSymptomsSystemTestingTherapeuticTimeTracheaWorkXylitolaerosolizedairway epitheliumairway inflammationairway surface liquidantimicrobialbasechildren with cystic fibrosiscystic fibrosis airwaycystic fibrosis patientsdesigndirect applicationefficacy testinghuman datain vivokillingspathogenpreventradiotracerresearch studyrespiratorysalt sensitivesugartime intervaltreatment effecttrenduptake
中文摘要
CF是一种多系统疾病,但气道感染是最重要的临床问题。最初的感染是由多种生物体引起的,通常可以通过抗生素根除(1,2)。在疾病后期,铜绿假单胞菌建立永久定植(1)。这种定植导致持续的呼吸道症状、气道炎症和最终的呼吸衰竭。
英文摘要
CF is a multi-system disease, however, infection in the airways is the most important clinical problem. Initial infections are caused by a variety of organisms, and often can be eradicated by antibiotics (1, 2). Later in the disease, P. aeruginosa establishes permanent colonization (1). This colonization results in persistent respiratory symptoms, airway inflammation and eventual respiratory failure.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
In Vitro Models and Cell Culture Core
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批准号:10470333
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项目类别:
-
资助金额:$18.54万
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财政年份:2020
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负责人:Joseph Zabner
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依托单位:
In Vitro Models and Cell Culture Core
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批准号:10248525
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项目类别:
-
资助金额:$18.54万
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财政年份:2020
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负责人:Joseph Zabner
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依托单位:
In Vitro Models and Cell Culture Core
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批准号:10024663
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项目类别:
-
资助金额:$18.54万
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财政年份:2020
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负责人:Joseph Zabner
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依托单位:
In Vitro Models and Cell Culture Core
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批准号:10677585
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项目类别:
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资助金额:$18.54万
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财政年份:2020
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负责人:Joseph Zabner
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依托单位:
Directed evolutioni of AAV for gene theraphy in a pig model of cystic fibrosis
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批准号:7741474
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项目类别:
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资助金额:$28.86万
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财政年份:2009
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负责人:Joseph Zabner
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依托单位:
Cell Culture Core
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批准号:7741487
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项目类别:
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资助金额:$28.86万
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财政年份:2009
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负责人:Joseph Zabner
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依托单位:
Request for Funds to Purchase a Replacement Laser Scanning Confocal Microscope
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批准号:7591586
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项目类别:
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资助金额:$50.0万
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财政年份:2009
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负责人:Joseph Zabner
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依托单位:
Project 3: Contribution of Small Airways to Cystic Fibrosis Lung Disease Pathogenesis
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批准号:10226940
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项目类别:
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资助金额:$35.69万
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财政年份:2008
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负责人:Joseph Zabner
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依托单位:
Project 3: Contribution of Small Airways to Cystic Fibrosis Lung Disease Pathogenesis
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批准号:10470212
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项目类别:
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资助金额:$35.69万
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财政年份:2008
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负责人:Joseph Zabner
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依托单位:
Early airway infection in a porcne model of cystic fibrosis
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批准号:7486390
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项目类别:
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资助金额:$28.81万
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财政年份:2008
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负责人:Joseph Zabner
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依托单位:
Cells and Tissue Core
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批准号:7688345
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项目类别:
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资助金额:$16.88万
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财政年份:2008
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负责人:Joseph Zabner
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依托单位:
in Vitro Models and Cell Culture Core
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批准号:7486395
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项目类别:
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资助金额:$7.51万
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财政年份:2008
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负责人:Joseph Zabner
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依托单位:
SAFETY OF AEROSOLIZED XYLITOL IN SUBJECTS WITH CYSTIC FIBROSIS
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批准号:7377064
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项目类别:
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资助金额:$0.23万
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财政年份:2006
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负责人:Joseph Zabner
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依托单位:
BRONCHOSCOPIC ASSESSMENT OF AIRWAY RETENTION TIME OF AEROSOLIZED XYLITOL
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批准号:7201351
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项目类别:
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资助金额:$0.52万
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财政年份:2005
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负责人:Joseph Zabner
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依托单位:
Ligand-Receptor Segregation and Airway Remodeling
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批准号:6822837
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项目类别:
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资助金额:$33.19万
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财政年份:2004
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负责人:Joseph Zabner
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依托单位:
Core-- Administration
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批准号:6853157
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项目类别:
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资助金额:$7.25万
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财政年份:2004
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负责人:Joseph Zabner
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依托单位:
Interactions of AAV5 with Sialic Acid and PDGF Receptors
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批准号:6853149
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项目类别:
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资助金额:$19.5万
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财政年份:2004
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负责人:Joseph Zabner
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依托单位:
Ligand-Receptor Segregation and Airway Remodeling
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批准号:6942288
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项目类别:
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资助金额:$33.19万
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财政年份:2004
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负责人:Joseph Zabner
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依托单位:
Effect of Ionic Versus Non-Ionic Osmolytes in the Airway
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批准号:7040797
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项目类别:
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资助金额:$0.34万
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财政年份:2004
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负责人:Joseph Zabner
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依托单位:
Ligand-Receptor Segregation and Airway Remodeling
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批准号:7104251
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项目类别:
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资助金额:$32.41万
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财政年份:2004
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负责人:Joseph Zabner
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依托单位:
海外基金