Ancillary Study 1

辅助研究1

• 批准号: 7934327
• 负责人: Joseph Zabner
• 金额: $ 120.54万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7934327
• 关键词: Acute; Adult; Affect; Air; Alleles; Ancillary Study; Anti-Bacterial Agents; Antibiotics; Area; Bacteria; C14 isotope; Carbohydrates; Carbon; Chronic; Chronic Bronchitis; Clinical; Clinical Research; Cystic Fibrosis Transmembrane Conductance Regulator; Data; Defect; Dental caries; Disease; Dose; Early treatment; Epithelial; Epithelium; Equilibrium; Evaluation; Family suidae; Figs - dietary; Genotype; Glucose; Goals; Grant; Growth; Haemophilus influenzae; Height; Human; In Vitro; Incidence; Infection; Infection prevention; Life; Liquid substance; Lobe; Longitudinal Studies; Lung; Mannitol; Measurement; Measures; Mediating; Methods; Microbiology; Morphology; Mucociliary Clearance; Natural Immunity; Neonatal; Newborn Infant; Organism; Osmolar Concentration; Otitis Media; Permeability; Phenotype; Procedures; Property; Pseudomonas aeruginosa; Radioactive Tracers; Reaction Time; Relative (related person); Reporting; Research Design; Respiratory Failure; Saline; Sampling; Shock; Sodium Chloride; Solutions; Source; Specimen; Staphylococcus aureus; Surface; Sweetening Agents; Symptoms; System; Testing; Therapeutic; Time; Trachea; Work; Xylitol; aerosolized; airway epithelium; airway inflammation; airway surface liquid; antimicrobial; base; children with cystic fibrosis; cystic fibrosis airway; cystic fibrosis patients; design; direct application; efficacy testing; human data; in vivo; killings; pathogen; prevent; radiotracer; research study; respiratory; salt sensitive; sugar; time interval; treatment effect; trend; uptake

CF is a multi-system disease, however, infection in the airways is the most important clinical problem. Initial infections are caused by a variety of organisms, and often can be eradicated by antibiotics (1, 2). Later in the disease, P. aeruginosa establishes permanent colonization (1). This colonization results in persistent respiratory symptoms, airway inflammation and eventual respiratory failure.

CF是一种多系统疾病，但气道感染是最重要的临床问题。最初的感染是由各种生物体引起的，通常可以通过抗生素根除（1，2）。在疾病后期，铜绿假单胞菌建立永久性定植（1）。这种定殖导致持续的呼吸道症状、气道炎症和最终的呼吸衰竭。