Administrative Core

本计划项目的核心旨在支持所有三个研究项目，并协调 项目之间的信息流和临床隔离。它有三个子组件：一个集中 关于项目的整体管理和协调，第二个重点是制定共享 数据库和分析能力，第三个旨在将临床结核分枝杆菌分离株存档为 被引导到各种项目中。核心的总体目标是：最大限度地提高 调查团队；促进在项目中动态交换想法、数据和结果 在不同活动的背景下；并向广大受众传播主要调查结果。具体的 目标是： 1)为所有项目提供行政支持和管理。 2)确定并为项目创造机会，以分享数据、成果、方法发展、 寻求原创的调查合作，并保持彼此之间以及与其他人之间的实质性联系 正在进行的项目。 3)创建一个具有明确定义的方法、通用培训和数据的有效和可访问的数据库 保护保障措施。 4)建立一个安全的微生物实验室资料库，存放药物敏感和耐药的M。 并对这些菌株进行分子基因分型、提取DNA和脂类作为 以及现场药敏试验的质量控制。 5)广泛传播科学方法、仪器和工具以及详细的数据和结果 多条路。

The Core of this Program Project is designed to support all three research projects and to coordinate the flow of information and clinical isolates among the projects. It has three subcomponents: one concentrated on overall management and coordination of the projects, a second focused on development of a shared database and analytic capability, and a third aimed at archiving clinical M. tuberculosis isolates to be channeled to the various projects. The overall goals of the Core are: to maximize the effectiveness of the team of investigators; to facilitate dynamic exchange of ideas, data, and results across projects in the context of their diverse activities; and to disseminate the key findings to a broad audience. The specific aims are: 1) to provide administrative support and management for all projects. 2) to identify and create opportunities for the projects to share data, results, methodological developments, pursue original investigative collaborations, and sustain substantive links with one another and with other ongoing projects. 3) to create an effective and accessible database with well defined methods, common training, and data protection safeguards. 4) to create a safe microbiological laboratory repository for archived drug sensitive and drug resistant M. tuberculosis strains and to conduct molecular genotyping, extraction of DMA and lipids for these strains as well as quality control of drug sensitivity testing for field sites. 5) to disseminate widely scientific methods, instruments and tools, and detailed data and results through multiple avenues.