Role of the NCoR corepressor complex in the development of insulin resistance
NCoR 辅阻遏物复合物在胰岛素抵抗发展中的作用
基本信息
- 批准号:8138837
- 负责人:
- 金额:$ 24.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-25 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
PROGRESS REPORT AND UPDATED RESEARCH PLAN
The main goal of this grant was to investigate the role of a transcriptional cofactor, GPS2, and its novel interacting partner, NEURL4/KIAA1787, in obesity-associated inflammatory responses and in the development of insulin resistance. Our original hypothesis was that these two proteins could play a key inhibitory role during the physiological response to insuHn signaling by keeping the NFKB and APi signaling network under negative control in the absence of stimulatory signals. The loss or downregulation of such inhibition may participate in the development of obesity-induced insulin resistance. Three Specific Aims were proposed: i) To define GPS2-dependent gene networks in adipocytes; ii) To investigate the molecular mechanism of GPS2 and KIAA1787 functions in inhibiting JNK-mediated signaling and regulating transcriptional activation mediated by NFKB and APi transcription factors; iii) To test in vivo whether GPS2 and KIAA1787 are relevant for the development of insulin resistance by creating null mice models.
Here, for each Aim, I will discuss the progresses made during the K99 phase of the award and describe the future experiments as the original plans have been updated in light ofthe current results.
进展报告和更新的研究计划
该资助的主要目标是研究转录辅助因子 GPS2 及其新型相互作用伙伴 NEURL4/KIAA1787 在肥胖相关炎症反应和胰岛素抵抗发展中的作用。我们最初的假设是,这两种蛋白可以在胰岛素信号传导的生理反应过程中发挥关键的抑制作用,通过在没有刺激信号的情况下将 NFKB 和 APi 信号网络置于负控制之下。这种抑制作用的丧失或下调可能参与肥胖诱导的胰岛素抵抗的发展。提出了三个具体目标: i) 定义脂肪细胞中依赖 GPS2 的基因网络; ii) 研究GPS2和KIAA1787抑制JNK介导的信号传导以及调节NFKB和APi转录因子介导的转录激活的分子机制; iii) 通过创建无效小鼠模型来体内测试 GPS2 和 KIAA1787 是否与胰岛素抵抗的发展相关。
在这里,对于每个目标,我将讨论在奖励的 K99 阶段取得的进展,并描述未来的实验,因为原始计划已根据当前结果进行了更新。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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VALENTINA PERISSI其他文献
VALENTINA PERISSI的其他文献
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{{ truncateString('VALENTINA PERISSI', 18)}}的其他基金
Coordination of PAR and Ub signaling in mitochondria
线粒体中 PAR 和 Ub 信号传导的协调
- 批准号:
10623889 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
Regulation of mitochondrial homeostasis through retrograde signaling
通过逆行信号调节线粒体稳态
- 批准号:
9924614 - 财政年份:2018
- 资助金额:
$ 24.9万 - 项目类别:
Regulation of mitochondrial homeostasis through retrograde signaling
通过逆行信号调节线粒体稳态
- 批准号:
10133090 - 财政年份:2018
- 资助金额:
$ 24.9万 - 项目类别:
Ubiquitin-dependent regulation of inflammation and insulin resistance
炎症和胰岛素抵抗的泛素依赖性调节
- 批准号:
9243244 - 财政年份:2014
- 资助金额:
$ 24.9万 - 项目类别:
Ubiquitin-dependent regulation of inflammation and insulin resistance
炎症和胰岛素抵抗的泛素依赖性调节
- 批准号:
9040938 - 财政年份:2014
- 资助金额:
$ 24.9万 - 项目类别:
Role of the NCoR corepressor complex in the development of insulin resistance
NCoR 辅阻遏物复合物在胰岛素抵抗发展中的作用
- 批准号:
8328959 - 财政年份:2010
- 资助金额:
$ 24.9万 - 项目类别:
Role of the NCoR corepressor complex in the development of insulin resistance
NCoR 辅阻遏物复合物在胰岛素抵抗发展中的作用
- 批准号:
8149970 - 财政年份:2010
- 资助金额:
$ 24.9万 - 项目类别:
Role of the NCoR corepressor complex in the development of insulin resistance
NCoR 辅阻遏物复合物在胰岛素抵抗发展中的作用
- 批准号:
7300065 - 财政年份:2007
- 资助金额:
$ 24.9万 - 项目类别:
Role of the NCoR corepressor complex in the development of insulin resistance
NCoR 辅阻遏物复合物在胰岛素抵抗发展中的作用
- 批准号:
7456334 - 财政年份:2007
- 资助金额:
$ 24.9万 - 项目类别:
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