Research Training on Intracellular Pathogens

细胞内病原体研究培训

• 批准号: 7799830
• 负责人: KENNETH D STUART
• 金额: $ 18.71万
• 依托单位: SEATTLE BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-20 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7799830
• 关键词: Area; Bioinformatics; Collaborations; Communicable Diseases; Country; Development; Disease; Educational workshop; Enrollment; Ethics; Faculty; Genetic Engineering; Genus Mycobacterium; Immunocompromised Host; India; Institution; International; Laboratories; Leishmania; Leishmaniasis; Malaria; Plasmodium; Research; Research Personnel; Research Project Grants; Research Training; Risk; Students; Training; Training Programs; Tuberculosis; Universities; Visceral; Visit; Work; base; design; experience; international center; pathogen; programs

DESCRIPTION (provided by applicant): This research-training program will be conducted in the context of international collaborations and is designed to provide training for international trainees who are in graduate degree programs, for postdoctorates and for faculty researchers in India, primarily at Jawaharlal Nehru University (JNU) in New Delhi. The program is designed to provide training, stimulate collaboration between JNU and SBRI/UW researchers, and provide research strengthening for JNU and its interacting Indian research institutions, particularly the International Centre for Genetic Engineering and Biotechnology (ICGEB) in New Delhi. The training program will be conducted in association with research projects on infectious diseases of global importance and which are of critical importance to India. The training will emphasize research training on intracelluar pathogens with a focus on the Leishmania, Plasmodium, and Mycobacterium. These emphases have been chosen because of the problems of leishmaniasis (especially visceral disease), malaria, and tuberculosis in India are worsening for a variety of reasons and since Leishmania and TB are opportunists, putting immunocompromised patients at risk. Training will highlight the combination of laboratory experimentation and bioinformatics and will build on established JNU SBRI/UW research collaborations and stimulate the development of new ones. The training will include in-country workshops on alternate years that have been so successful in the past. These will include laboratory and didactic training and provide a part of the basis for selecting trainees for a research training experience in Seattle. Seattle-based training will provide for a portion of graduate degree program research requirements for student trainees who are enrolled in graduate degree programs at JNU or at the UW. Training will also be available in Seattle for Indian postdoctorals participating in international collaborations and for short working visits of collaborating JNU faculty. The training will also provide opportunities for interactions among trainees from various international training programs (especially FIC supported) and include training in areas of importance that is common to these programs such as regulatory and ethical aspects. The Indian partner institution will be JNU to stimulate additional research collaborations and to take advantage of its working linkages with other key Indian research institutions such as ICGEB.

描述（由申请人提供）：该研究培训计划将在国际合作的背景下进行，旨在为新德里的Jawaharlal Nehru大学（JNU）的印度研究生学位课程，博士后和教职研究人员提供培训。该计划旨在提供培训，刺激JNU与SBRI/UW研究人员之间的协作，并为JNU及其互动的印度研究机构，特别是新德里的国际基因工程与生物技术中心（ICGEB）提供研究加强。该培训计划将与有关全球重要性的传染病研究项目共同开展，这对印度至关重要。该培训将强调对细胞内病原体的研究培训，重点是利什曼原虫，疟原虫和分枝杆菌。之所以选择这些重点，是因为利什曼病（尤其是内脏疾病），印度疟疾和结核病的问题因多种原因而恶化，并且由于利什曼尼亚和结核病是机会主义者，因此使免疫强化的患者置于危险之中。培训将突出实验室实验和生物信息学的结合，并将基于既定的JNU SBRI/UW研究合作，并刺激新研究的发展。培训将包括过去在过去如此成功的替代年份的内部研讨会。这些将包括实验室和教学培训，并为在西雅图的研究培训经验选择受训者提供了一部分。基于西雅图的培训将为在JNU或UW参加研究生学位课程的学生学员的研究生学位课程研究要求中提供一部分。还将在西雅图为参加国际合作的印度博士后提供培训，并进行简短的JNU教职员工访问。该培训还将为来自各种国际培训计划（尤其是FIC支持）的受训者之间的互动提供机会，并包括对这些计划（例如监管和道德方面）共有的重要性领域的培训。印度合作伙伴机构将是JNU，旨在刺激其他研究合作，并利用其与ICGEB等印度其他主要研究机构的工作联系。

项目成果

Pulmonary infections after renal transplantation: a prospective study from a tropical country.

肾移植后肺部感染：来自热带国家的一项前瞻性研究。

• DOI: 10.1111/tri.13817
• 发表时间: 2021
• 期刊: Transplant international : official journal of the European Society for Organ Transplantation
• 作者: Mangalgi,Shreepriya;Madan,Karan;Das,ChandanJ;Singh,Gagandeep;Sati,Hemchandra;KanwarYadav,Raj;Xess,Immaculata;Singh,Sarman;Bhowmik,Dipankar;Agarwal,SanjayKumar;Bagchi,Soumita
• 通讯作者: Bagchi,Soumita

Expression and characterization of catalytic domain of Plasmodium falciparum subtilisin-like protease 3.

恶性疟原虫枯草杆菌蛋白酶3催化结构域的表达和表征。

• DOI: 10.1016/j.molbiopara.2011.12.009
• 发表时间: 2012
• 期刊: Molecular and biochemical parasitology
• 影响因子: 1.5
• 作者: Alam,Asrar;Bhatnagar,RajK;Chauhan,ViranderS
• 通讯作者: Chauhan,ViranderS

Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12.

• DOI: 10.1016/j.immuni.2013.06.003
• 发表时间: 2013-06-27
• 期刊: Immunity
• 影响因子: 32.4
• 作者: Shafiani S;Dinh C;Ertelt JM;Moguche AO;Siddiqui I;Smigiel KS;Sharma P;Campbell DJ;Way SS;Urdahl KB
• 通讯作者: Urdahl KB

Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3.

• DOI: 10.1016/j.molbiopara.2010.12.009
• 发表时间: 2011-04
• 期刊: MOLECULAR AND BIOCHEMICAL PARASITOLOGY
• 影响因子: 1.5
• 作者: Kayode, K. Ojo;Arakaki, Tracy L.;Napuli, Alberto J.;Inampudi, Krishna K.;Keyloun, Katelyn R.;Zhang, Li;Hol, Wim G. J.;Verlinde, Christophe L. M. J.;Merritt, Ethan A.;Van Voorhis, Wesley C.
• 通讯作者: Van Voorhis, Wesley C.

Genetic analysis of Leishmania donovani tropism using a naturally attenuated cutaneous strain.

使用自然减毒皮肤菌株对杜氏利什曼原虫向性进行遗传分析。

• DOI: 10.1371/journal.ppat.1004244
• 发表时间: 2014
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Zhang,WenWei;Ramasamy,Gowthaman;McCall,Laura-Isobel;Haydock,Andrew;Ranasinghe,Shalindra;Abeygunasekara,Priyanka;Sirimanna,Ganga;Wickremasinghe,Renu;Myler,Peter;Matlashewski,Greg
• 通讯作者: Matlashewski,Greg