Immune Responses to Malaria and HIV Infection and Immunization

对疟疾和艾滋病毒感染的免疫反应和免疫接种

• 批准号: 10198675
• 负责人: KENNETH D STUART
• 金额: $ 356.11万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-19 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198675
• 关键词: AIDS/HIV problem; Communicable Diseases; Communities; Disease; Environmental Exposure; Foundations; Goals; HIV; HIV Infections; HIV immunization; HIV-1; Health Status; Human; Immune; Immune response; Immune system; Immunity; Immunology; Infection; Malaria; Molecular Profiling; Pathway Analysis; Plasmodium falciparum; Population; Research; Systems Biology; Technology; Vaccination; Vaccine Adjuvant; Vaccines; data standards; design; insight; malaria infection; pathogen; response; vaccine development; vaccine efficacy

Malaria and HIV/AIDS are two of the most devastating infectious diseases, impacting millions of people world- wide. Effective vaccines against the pathogens that cause these diseases (HIV and Plasmodium falciparum) have proven elusive and traditional vaccine approaches are unlikely to succeed in eradicating either disease. In addition to our limited understanding of the desired immune responses to confer protection against the pathogens and our limited ability to elicit such responses, vaccine efficacy is also confounded by the diversity of pathogens, human populations, environmental exposures, and health status. The projects described herein are designed to support the identification of immune profiles that correlate with vaccine efficacy and are of potential relevance to protection against HIV-1 and P. falciparum infection. Beyond the importance of combatting these diseases, the strategies for profiling immunity in response to infection and vaccination hold promise for garnering fundamental insights into the complexity of the immune system as a whole. Such insight will have potential for impacting strategies for vaccine development and for treating immune-related diseases more broadly.

疟疾和艾滋病毒/艾滋病是两种最具破坏性的传染病，影响着全世界数百万人