Immune Responses to Malaria and HIV Infection and Immunization

对疟疾和艾滋病毒感染的免疫反应和免疫接种

• 批准号: 10198675
• 负责人: KENNETH D STUART
• 金额: $ 356.11万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-19 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198675
• 关键词: AIDS/HIV problem; Communicable Diseases; Communities; Disease; Environmental Exposure; Foundations; Goals; HIV; HIV Infections; HIV immunization; HIV-1; Health Status; Human; Immune; Immune response; Immune system; Immunity; Immunology; Infection; Malaria; Molecular Profiling; Pathway Analysis; Plasmodium falciparum; Population; Research; Systems Biology; Technology; Vaccination; Vaccine Adjuvant; Vaccines; data standards; design; insight; malaria infection; pathogen; response; vaccine development; vaccine efficacy

Malaria and HIV/AIDS are two of the most devastating infectious diseases, impacting millions of people world- wide. Effective vaccines against the pathogens that cause these diseases (HIV and Plasmodium falciparum) have proven elusive and traditional vaccine approaches are unlikely to succeed in eradicating either disease. In addition to our limited understanding of the desired immune responses to confer protection against the pathogens and our limited ability to elicit such responses, vaccine efficacy is also confounded by the diversity of pathogens, human populations, environmental exposures, and health status. The projects described herein are designed to support the identification of immune profiles that correlate with vaccine efficacy and are of potential relevance to protection against HIV-1 and P. falciparum infection. Beyond the importance of combatting these diseases, the strategies for profiling immunity in response to infection and vaccination hold promise for garnering fundamental insights into the complexity of the immune system as a whole. Such insight will have potential for impacting strategies for vaccine development and for treating immune-related diseases more broadly.

疟疾和艾滋病毒/艾滋病是两种最具破坏性的传染病，影响着全球数百万人-- 很宽。针对引起这些疾病的病原体(艾滋病毒和恶性疟原虫)的有效疫苗 已经被证明是难以捉摸的，传统的疫苗方法不太可能成功根除这两种疾病。 除了我们对所需免疫反应的有限了解之外，我们还可以提供对 病原体和我们诱导这种反应的能力有限，疫苗的效力也被多样性所混淆 病原体、人口、环境暴露和健康状况。在此描述的项目 旨在支持识别与疫苗效力相关的免疫配置文件，并具有 预防HIV-1和恶性疟原虫感染的潜在相关性。超越……的重要性 抗击这些疾病，应对感染和疫苗接种的概况免疫战略 有望获得对免疫系统作为一个整体的复杂性的基本见解。这种洞察力 将有可能影响疫苗开发和治疗免疫相关疾病的战略 更广泛地说。