Biennial Symposium of H. ducreyi Pathogenesis and Chancroid

杜克雷螺杆菌发病机制与软下疳双年研讨会

• 批准号: 8130005
• 负责人: Stanley M. Spinola
• 金额: $ 0.8万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-15 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8130005
• 关键词: Africa; Area; Austria; Basic Science; Biology; Canada; Cities; Clinical; Clinical Research; Developing Countries; Disease; Epidemiologist; Epidemiology; Europe; Faculty; Fostering; Funding; Genital system; Goals; HIV-1; Health Personnel; Hemophilus ducreyi; Heterosexuals; Immune response; International; Letters; Location; Names; National Institute of Allergy and Infectious Disease; North America; Organism; Participant; Pathogenesis; Postdoctoral Fellow; Public Health; Quebec; Research; Research Personnel; Scientist; Series; Societies; Students; Travel; Ulcer; United States; Work; cost; disorder control; graduate student; human disease; interdisciplinary approach; meetings; neglect; new therapeutic target; pathogen; programs; symposium; transmission process; vaccine development

DESCRIPTION (provided by applicant): Haemophilus ducreyi, which causes the genital ulcer disease chancroid, was overlooked as a significant cause of human disease until the late1980's, when several thousand cases of chancroid occurred in the United States and chancroid was found to be a major co-factor in the heterosexual transmission of HIV-1 in Africa. In 1991, the first in a series of biennial International Symposia on H. ducreyi Pathogenesis and Chancroid was held in conjunction with the International Society for STD research (ISSTDR) International Meeting. The purpose of the meeting was to promote progress in our ability to understand the biology and epidemiology of this neglected pathogen and to devise strategies to eradicate chancroid. The H. ducreyi symposium is a satellite symposium of the ISSTDR, which meets every two years, alternating between North America and Europe. This specific proposal is to request funds to assist in sponsoring the H. ducreyi symposium, specifically to partially underwrite program costs and the expense of travel of graduate students, postdoctoral fellows, and young faculty presenters to the next three iterations of the meeting. The 11th and 12th International Symposia will be held in Quebec City and Vienna respectively; the venue for the 13th meeting has not been determined. The major objective of the Symposium is to provide a forum for exchange of information on clinical and basic aspects of chancroid and other agents of genital ulcer disease, and to provide the opportunity for students, post-doctoral fellows and new investigators to present their research on this organism. In connecting the H. ducreyi symposium to the ISSTDR meeting, we provide participants the ability to interact with clinicians, epidemiologists, public health personnel and basic scientists who work in the broad area of STD research. The meeting also fosters interaction between investigators from the United States with those from developing countries where chancroid is endemic. Our goal is to encourage basic and clinical research in the biology of H. ducreyi and chancroid in the areas of pathogenesis, host responses, vaccine development, identification of novel therapeutic targets, epidemiology, and disease control. An approval letter from Dr. Katrin Eichelberg from the NIAID can be found in the PHS398 Cover Letter File attachment of this application. PUBLIC HEALTH RELEVANCE: Haemophilus ducreyi causes a genital ulcer disease called chancroid, which facilitates HIV-1 transmission. This is a request for funds to support an international meeting to discuss research on H. ducreyi in 2011, 2013 and 2015.

描述（由申请人提供）：引起生殖器溃疡病软下疳的杜克雷嗜血杆菌一直被忽视为人类疾病的重要原因，直到20世纪80年代末，美国出现了数千例软下疳病例，并且发现软下疳是非洲HIV-1异性传播的主要辅助因素。 1991 年，两年一度的杜克雷螺杆菌发病机制和软下疳系列国际研讨会中的第一场与国际性传播疾病研究学会 (ISSTDR) 国际会议同时举行。这次会议的目的是促进我们了解这种被忽视的病原体的生物学和流行病学的能力，并制定根除软下疳的策略。 H. ducreyi 研讨会是 ISSTDR 的附属研讨会，每两年举行一次，在北美和欧洲轮流举行。该具体提案旨在申请资金协助赞助 H. ducreyi 研讨会，特别是部分承担项目费用以及研究生、博士后研究员和年轻教师演讲者参加接下来三届会议的旅费。第11届和第12届国际研讨会将分别在魁北克市和维也纳举行；第13次会议的地点尚未确定。研讨会的主要目的是提供一个论坛，交流软下疳和生殖器溃疡病其他病原体的临床和基本方面的信息，并为学生、博士后研究员和新研究人员提供展示他们对该生物体的研究的机会。通过将 H. ducreyi 研讨会与 ISSTDR 会议联系起来，我们为参与者提供了与从事 STD 研究广泛领域工作的临床医生、流行病学家、公共卫生人员和基础科学家进行互动的能力。这次会议还促进了美国研究人员与软下疳流行的发展中国家研究人员之间的互动。我们的目标是鼓励杜克雷螺杆菌和软下疳生物学在发病机制、宿主反应、疫苗开发、新治疗靶点的鉴定、流行病学和疾病控制等领域的基础和临床研究。来自 NIAID 的 Katrin Eichelberg 博士的批准信可以在本申请的 PHS398 求职信文件附件中找到。 公共卫生相关性：杜克雷嗜血杆菌会引起一种称为软下疳的生殖器溃疡病，这种疾病会促进 HIV-1 传播。这是一项资金申请，用于支持 2011 年、2013 年和 2015 年讨论 H. ducreyi 研究的国际会议。