Osteocyte regulation of bone mass

骨细胞对骨量的调节

• 批准号: nhmrc : GNT1106029
• 负责人: A/Pr Paul Anderson
• 金额: $ 83.76万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/osteocyte-regulation-bone-mass/1346484
• 关键词: Osteocyte; regulation; bone; mass

Osteocytes, the most abundant and long-lived, yet least studied bone cell, are increasingly recognised as key controllers of bone remodelling and are implicated in many bone diseases. Our work is uncovering novel molecular and cellular pathways by which osteocytes act and survive in bone, which is generally an oxygen-deprived tissue. This will provide a rational basis to seek improved treatments of bone disease.

骨细胞是最丰富、最长寿、但研究最少的骨细胞，越来越多地被认为是骨重塑的关键控制器，并且与许多骨疾病有关。我们的工作正在揭示骨细胞在骨骼（通常是缺氧组织）中发挥作用和生存的新分子和细胞途径。这将为寻求骨病的改进治疗提供合理的基础。