Strategies for healthy osteocytes

健康骨细胞的策略

• 批准号: nhmrc : 565372
• 负责人: A/Pr Paul Anderson
• 金额: $ 34.09万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/strategies-healthy-osteocytes/76104
• 关键词: Strategies; healthy; osteocytes

Osteocytes (OY) are the most abundant cell type in bone whose high density and viability are essential for healthy bone. We have found that vitamin K, vitamin D and strontium, promote human OY differentiation. We will test these in novel models of human OY differentiation and survival, and in animal models of bone loss associated with vitamin D deficiency, menopause and glucocorticoid treatment. Our work will lead to a better understanding of human OY and give a new approach to treat osteoporosis.

骨细胞（OY）是骨中最丰富的细胞类型，其高密度和活力是健康骨所必需的。我们已经发现，维生素K、维生素D和锶促进人OY分化。我们将在人类OY分化和存活的新模型，以及与维生素D缺乏、绝经和糖皮质激素治疗相关的骨丢失动物模型中测试这些。我们的工作将导致更好地了解人类OY，并提供一个新的方法来治疗骨质疏松症。