Control of bone remodelling by osteoclastic metabolism of vitamin D

通过维生素 D 的破骨细胞代谢控制骨重塑

• 批准号: nhmrc : 1029926
• 负责人: A/Pr Paul Anderson
• 金额: $ 46.32万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-bone-remodelling-vitamin-d/110720
• 关键词: Control; bone; remodelling; osteoclastic; metabolism

Vitamin D is essential for bone health. This study will build on our extensive body of preliminary data to investigate the extent to which bone-resorbing osteoclasts are controlled by circulating levels of the pro-hormone 25-hydroxyvitamin D. Our work will identify new approaches to the treatment of osteoporosis, by targetting the osteoclast as a vitamin D-responsive cell type.

维生素D对骨骼健康至关重要。这项研究将建立在我们广泛的初步数据的基础上，以调查骨吸收破骨细胞在多大程度上受到前激素25-羟基维生素D循环水平的控制。我们的工作将确定治疗骨质疏松症的新方法，通过靶向破骨细胞作为维生素D反应细胞类型。