The role of Vitamin D in placental development and pregnancy success

维生素D缺乏症影响着全球约10亿人，其中高达80%的澳大利亚人因年龄、肤色和日晒而异。维生素D缺乏症现在与许多常见的衰老疾病和妊娠并发症有关。这项建议将使用人类妊娠血清和胎盘，以及小鼠基因敲除模型，以确定迄今未知的维生素D在胎盘发育和母婴健康中的作用。

Vitamin D deficiency affects about 1 billion people worldwide, including up to 80% of Australians depending on age, skin colour and sun exposure. Vitamin D deficiency has now been associated with a large number of common diseases of aging and with pregnancy complications. This proposal will use human pregnancy serum and placenta, as well as mouse gene knockout models, to determine the hitherto unknown roles of vitamin D in development of the placenta and health of mother and baby.