The role of Vitamin D in placental development and pregnancy success

维生素 D 在胎盘发育和妊娠成功中的作用

• 批准号: nhmrc : 1020754
• 负责人: A/Pr Paul Anderson
• 金额: $ 48.23万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-vitamin-d-pregnancy-success/110063
• 关键词: role; Vitamin; placental; development; pregnancy

Vitamin D deficiency affects about 1 billion people worldwide, including up to 80% of Australians depending on age, skin colour and sun exposure. Vitamin D deficiency has now been associated with a large number of common diseases of aging and with pregnancy complications. This proposal will use human pregnancy serum and placenta, as well as mouse gene knockout models, to determine the hitherto unknown roles of vitamin D in development of the placenta and health of mother and baby.

全球约有10亿人缺乏维生素D，其中包括高达80%的澳大利亚人，这取决于年龄、肤色和日晒情况。维生素D缺乏与许多常见的老年疾病和妊娠并发症有关。这项提议将使用人类妊娠血清和胎盘，以及小鼠基因敲除模型，来确定迄今为止未知的维生素D在胎盘发育和母婴健康中的作用。