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Does enhanced vitamin D activity in bone heal the skeleton in disorders of FGF23 excess?

Does enhanced vitamin D activity in bone heal the skeleton in disorders of FGF23 excess?
骨骼中维生素 D 活性的增强能否治愈 FGF23 过量疾病中的骨骼?
批准号:
nhmrc : 1130338
负责人:
A/Pr Paul Anderson
金额:
$58.39万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2019-12-31

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英文摘要
X-linked hypophosphatemia (XLH) is a genetic disorder which results in phosphate wasting and rickets. This severe disorder has no effective treatment. We have compelling new evidence that the rickets in XLH is not primarily a disorder of low blood phosphate, but rather specific issue of low cellular levels and activity of vitamin D (1,25D) within bone. This proposal is designed to specifically demonstrate this new concept and outline a new paradigm for a new XLH treatment.
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Does enhanced vitamin D activity in bone heal the skeleton in disorders of FGF23 excess?
  • 批准号:
    nhmrc : GNT1130338
  • 项目类别:
    Project Grants
  • 资助金额:
    $85.59万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Paul Anderson
  • 依托单位:
Osteocyte regulation of bone mass
  • 批准号:
    nhmrc : 1106029
  • 项目类别:
    Project Grants
  • 资助金额:
    $57.64万
  • 财政年份:
    2016
  • 负责人:
    A/Pr Paul Anderson
  • 依托单位:
Osteocyte regulation of bone mass
  • 批准号:
    nhmrc : GNT1106029
  • 项目类别:
    Project Grants
  • 资助金额:
    $83.76万
  • 财政年份:
    2016
  • 负责人:
    A/Pr Paul Anderson
  • 依托单位:
Autocrine Vitamin D Metabolism, Activity and Bone Health
  • 批准号:
    nhmrc : 1051858
  • 项目类别:
    Career Development Fellowships
  • 资助金额:
    $30.62万
  • 财政年份:
    2013
  • 负责人:
    A/Pr Paul Anderson
  • 依托单位:
国内基金
海外基金
噬菌体靶向肠道粪肠球菌提高帕金森病左旋多巴疗效的机制研究
  • 批准号:
    82371251
  • 项目类别:
    面上项目
  • 资助金额:
    49.00万元
  • 批准年份:
    2023
  • 负责人:
    肖勤
  • 依托单位: