Does enhanced vitamin D activity in bone heal the skeleton in disorders of FGF23 excess?
Does enhanced vitamin D activity in bone heal the skeleton in disorders of FGF23 excess?
批准号:
nhmrc : 1130338
负责人:
A/Pr Paul Anderson
金额:
$58.39万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2019-12-31
中文摘要
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英文摘要
X-linked hypophosphatemia (XLH) is a genetic disorder which results in phosphate wasting and rickets. This severe disorder has no effective treatment. We have compelling new evidence that the rickets in XLH is not primarily a disorder of low blood phosphate, but rather specific issue of low cellular levels and activity of vitamin D (1,25D) within bone. This proposal is designed to specifically demonstrate this new concept and outline a new paradigm for a new XLH treatment.
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Does enhanced vitamin D activity in bone heal the skeleton in disorders of FGF23 excess?
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批准号:nhmrc : GNT1130338
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项目类别:Project Grants
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资助金额:$85.59万
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财政年份:2017
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负责人:A/Pr Paul Anderson
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依托单位:
Osteocyte regulation of bone mass
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批准号:nhmrc : 1106029
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项目类别:Project Grants
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资助金额:$57.64万
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财政年份:2016
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负责人:A/Pr Paul Anderson
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依托单位:
Osteocyte regulation of bone mass
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批准号:nhmrc : GNT1106029
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项目类别:Project Grants
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资助金额:$83.76万
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财政年份:2016
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负责人:A/Pr Paul Anderson
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依托单位:
Autocrine Vitamin D Metabolism, Activity and Bone Health
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批准号:nhmrc : 1051858
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项目类别:Career Development Fellowships
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资助金额:$30.62万
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财政年份:2013
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负责人:A/Pr Paul Anderson
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依托单位:
Control of bone remodelling by osteoclastic metabolism of vitamin D
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批准号:nhmrc : 1029926
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项目类别:Project Grants
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资助金额:$46.32万
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财政年份:2012
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负责人:A/Pr Paul Anderson
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依托单位:
The role of Vitamin D in placental development and pregnancy success
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批准号:nhmrc : 1020754
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项目类别:Project Grants
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资助金额:$48.23万
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财政年份:2012
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负责人:A/Pr Paul Anderson
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依托单位:
Vitamin D synthesis within osteoblasts increases bone mineral by regulating remodelling: Is this the link between vitamin D status and fractures?
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批准号:nhmrc : 1029756
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项目类别:Project Grants
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资助金额:$41.81万
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财政年份:2012
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负责人:A/Pr Paul Anderson
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依托单位:
Vitamin D Activity to Regulate Bone Remodelling and Promote Bone Strength
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批准号:nhmrc : 1003433
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项目类别:NHMRC Project Grants
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资助金额:$33.14万
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财政年份:2011
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负责人:A/Pr Paul Anderson
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依托单位:
The Regulation of Vitamin D-Dependent Bone Metabolism
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批准号:nhmrc : 565192
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项目类别:NHMRC Project Grants
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资助金额:$40.84万
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财政年份:2009
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负责人:A/Pr Paul Anderson
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依托单位:
Strategies for healthy osteocytes
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批准号:nhmrc : 565372
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项目类别:NHMRC Project Grants
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资助金额:$34.09万
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财政年份:2009
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负责人:A/Pr Paul Anderson
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依托单位:
国内基金
海外基金
噬菌体靶向肠道粪肠球菌提高帕金森病左旋多巴疗效的机制研究
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批准号:82371251
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项目类别:面上项目
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资助金额:49.00万元
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批准年份:2023
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负责人:肖勤
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依托单位: