Gordon Research Conference and Gordon-Kenan Research Seminar on Matrix Metallopro

描述（由申请人提供）：Gordon研究会议（GRC）关于基质金属蛋白酶（MMP）旨在为来自广泛学科的科学家和医生提供一个论坛，报告最新的研究成果并讨论这些医学相关蛋白酶的新概念。会议还涵盖了ADAMTS和ADAM金属蛋白酶的研究，使这些密切相关的金属蛋白酶的思想和概念得以交流。自1993年以来，MMP GRC每两年举行一次，出席人数众多，并在实现其目标方面取得了相当大的成功，在GRC组织的传统中，为前沿金属蛋白酶研究提供了一个重要的论坛。2011年MMP GRC将于2011年8月在RI Bryant大学举行，将继续努力成为MMP及相关蛋白酶的首要会议。为此，我们计划将来自不同学科的领先研究人员和初级研究人员聚集在一起，围绕会议的新主题：“基础科学与应用医学交叉的新兴金属蛋白酶研究”来展示和讨论他们最新的金属蛋白酶研究。本主题的主要目的是将金属蛋白酶结构和功能的基本分子和细胞机制的最新进展整合到成功的临床应用中。为了实现这一目标，我们计划开发一个一流的创新科学项目，重点讨论细胞和动物模型以及系统生物学、化学、蛋白质组学和基因组学的技术进步中出现的金属蛋白酶在疾病条件下功能的最新范式。该项目将包括来自该领域杰出研究者、早期独立研究者和新研究者的演讲。在本次会议的历史上，Gordon-Kenan研究研讨会（GRS）将首次由对金属蛋白酶研究感兴趣的博士后和研究生组织。GRS将为年轻研究人员提供一个独特而令人兴奋的论坛，以展示他们的研究并发现GRC的经验。GRS期间的活动将侧重于：(1)为初级研究人员提供学习和讨论MMPs在疾病中的常见机制和作用的基本背景的机会，以最大限度地提高他们对将在随后的GRC中讨论的科学的理解；(2)从该领域的同行和专家那里获得他们正在进行的研究项目的反馈和讨论他们的想法；(3)促进他们与该科学界的资深成员的互动，以促进他们的专业发展。我们充分期待2011年和未来MMP GRCs和GRSs参与者之间的科学讨论、研究会谈、海报会议和其他非正式互动将继续这些独特会议的传统，以促进我们对金属蛋白酶功能的理解，并将这些知识转化为人类疾病的新型治疗干预措施。

DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) on Matrix Metalloproteases (MMP) is designed to provide scientists and physicians from a wide range of disciplines with a forum to report the latest research findings and discuss new concepts on these medically relevant proteases. The conference also covers research on ADAMTS and ADAM metalloproteases to enable cross-fertilization of ideas and concepts on these closely related metalloproteinases. The MMP GRC has been held every two years since 1993 with a robust attendance and considerable success in accomplishing its goal of providing a premier forum for cutting-edge metalloproteinase research, in the tradition of the GRC organization. The 2011 MMP GRC, which will be held in August 2011 at Bryant University, RI, will continue to strive to be premier conference on MMPs and related proteases. To this end, we plan to bring together leading investigators and junior investigators from a variety of disciplines to present and discuss their latest metalloproteinase research around the new theme of the conference: "Emerging MMP Research at the Intersection of Basic Science and Applied Medicine." The main of objective of this theme is to integrate recent advances in basic molecular and cellular mechanisms of metalloproteinase structure and function into successful clinical applications. To achieve this objective, we plan to develop a first-rate and innovative scientific program that focuses on discussing recent paradigms on metalloproteinase function in disease conditions that are emerging from cellular and animal models and technological advances in system biology, chemistry, proteomics, and genomics. The program will include presentations from prominent investigators in the field, early-career independent investigators and new investigators. For the first time in the history of this conference, a Gordon-Kenan Research Seminar (GRS) on MMPs will be organized by postdoctoral fellows and graduate students with interest in metalloproteinase research. The GRS will provide a unique and exciting forum for young researchers to present their research and discover the GRC experience. Activities during the GRS will be oriented to: (1) provide junior investigators with the opportunity to learn and discuss basic background on common mechanisms and role of MMPs in disease to maximize their understanding of the science which will be discussed in the subsequent GRC, (2) receive feedback on their ongoing research projects from and discuss their ideas with peers and experts in the field, and (3) facilitate their interaction with senior members of this scientific community to promote their professional development. We fully anticipate that the scientific discussions, research talks, poster sessions, and other informal interactions between the participants at the 2011 and future MMP GRCs and GRSs will continue with the tradition of these unique conferences of advancing our understanding of metalloproteinase function towards the translation of this knowledge into novel therapeutic interventions in human diseases. PUBLIC HEALTH RELEVANCE: The Gordon Research Conference on Matrix Metalloproteinases established in 1993 is the most prestigious scientific conference in the field of metalloproteinases, a group of enzymes involved in the pathogenesis of many human diseases. The conference provides a forum to present the latest advances in cutting-edge metalloproteinase research and to educate the new generation of young investigators interested in the field. It is anticipated that the collegial and cooperative atmosphere that has traditionally characterized this conference will provide the perfect setting for the intellectual development and implementation of novel therapeutics in human diseases involving deregulated metalloproteinase activity.