Gordon Research Conference and Gordon-Kenan Research Seminar on Matrix Metallopro
戈登研究会议和戈登-凯南基体金属研究研讨会
基本信息
- 批准号:8119866
- 负责人:
- 金额:$ 0.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-04-01 至 2012-03-31
- 项目状态:已结题
- 来源:
- 关键词:ADAMTSAnimal Disease ModelsAnimal ModelBasic ScienceCardiovascular DiseasesCell modelCell physiologyChemistryCollaborationsCommunitiesComplexConnective Tissue DiseasesDevelopmentDisciplineDiseaseEnvironmentEnzymesFeedbackFertilizationFosteringFundingFutureGenerationsGenomicsGoalsInterventionJointsKnowledgeLearningLightMatrix MetalloproteinasesMedicineMetalloproteasesMolecularParticipantPathogenesisPathologic ProcessesPeptide HydrolasesPhysiciansPlayPostdoctoral FellowProcessProteomicsRecording of previous eventsReportingRequest for ApplicationsResearchResearch PersonnelResearch Project GrantsResourcesRoleScienceScientistStagingStructureSystems BiologyTimeTranslational ResearchUniversitiesbasecareerclinical applicationdesigndrug developmentexperiencegraduate studenthuman diseaseinnovationinterestknowledge translationmeetingsmembernovelnovel therapeutic interventionnovel therapeuticspeerplanetary Atmospherepostersprogramssuccesssymposiumtumor progression
项目摘要
DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) on Matrix Metalloproteases (MMP) is designed to provide scientists and physicians from a wide range of disciplines with a forum to report the latest research findings and discuss new concepts on these medically relevant proteases. The conference also covers research on ADAMTS and ADAM metalloproteases to enable cross-fertilization of ideas and concepts on these closely related metalloproteinases. The MMP GRC has been held every two years since 1993 with a robust attendance and considerable success in accomplishing its goal of providing a premier forum for cutting-edge metalloproteinase research, in the tradition of the GRC organization. The 2011 MMP GRC, which will be held in August 2011 at Bryant University, RI, will continue to strive to be premier conference on MMPs and related proteases. To this end, we plan to bring together leading investigators and junior investigators from a variety of disciplines to present and discuss their latest metalloproteinase research around the new theme of the conference: "Emerging MMP Research at the Intersection of Basic Science and Applied Medicine." The main of objective of this theme is to integrate recent advances in basic molecular and cellular mechanisms of metalloproteinase structure and function into successful clinical applications. To achieve this objective, we plan to develop a first-rate and innovative scientific program that focuses on discussing recent paradigms on metalloproteinase function in disease conditions that are emerging from cellular and animal models and technological advances in system biology, chemistry, proteomics, and genomics. The program will include presentations from prominent investigators in the field, early-career independent investigators and new investigators. For the first time in the history of this conference, a Gordon-Kenan Research Seminar (GRS) on MMPs will be organized by postdoctoral fellows and graduate students with interest in metalloproteinase research. The GRS will provide a unique and exciting forum for young researchers to present their research and discover the GRC experience. Activities during the GRS will be oriented to: (1) provide junior investigators with the opportunity to learn and discuss basic background on common mechanisms and role of MMPs in disease to maximize their understanding of the science which will be discussed in the subsequent GRC, (2) receive feedback on their ongoing research projects from and discuss their ideas with peers and experts in the field, and (3) facilitate their interaction with senior members of this scientific community to promote their professional development. We fully anticipate that the scientific discussions, research talks, poster sessions, and other informal interactions between the participants at the 2011 and future MMP GRCs and GRSs will continue with the tradition of these unique conferences of advancing our understanding of metalloproteinase function towards the translation of this knowledge into novel therapeutic interventions in human diseases.
PUBLIC HEALTH RELEVANCE: The Gordon Research Conference on Matrix Metalloproteinases established in 1993 is the most prestigious scientific conference in the field of metalloproteinases, a group of enzymes involved in the pathogenesis of many human diseases. The conference provides a forum to present the latest advances in cutting-edge metalloproteinase research and to educate the new generation of young investigators interested in the field. It is anticipated that the collegial and cooperative atmosphere that has traditionally characterized this conference will provide the perfect setting for the intellectual development and implementation of novel therapeutics in human diseases involving deregulated metalloproteinase activity.
描述(由申请人提供):关于基质金属蛋白酶(MMP)的戈登研究会议(GRC)旨在为来自广泛学科的科学家和医生提供一个论坛,以报告最新的研究结果并讨论这些医学相关蛋白酶的新概念。会议还涵盖了对ADAMTS和ADAM金属蛋白酶的研究,以使这些密切相关的金属蛋白酶的思想和概念的交叉受精。自1993年以来,MMP GRC每两年举办一次,出席人数众多,并在实现其目标方面取得了相当大的成功,即按照GRC组织的传统,为尖端金属蛋白酶研究提供一个首要论坛。2011年MMP GRC将于2011年8月在布莱恩大学举行,RI将继续努力成为MMPs和相关蛋白酶的首要会议。为此,我们计划将来自不同学科的主要研究人员和初级研究人员聚集在一起,围绕会议的新主题介绍和讨论他们最新的金属蛋白酶研究:“基础科学和应用医学交叉点的新兴MMP研究”。“这个主题的主要目标是将金属蛋白酶结构和功能的基本分子和细胞机制的最新进展整合到成功的临床应用中。为了实现这一目标,我们计划开发一个一流的和创新的科学计划,重点讨论最近的范例金属蛋白酶功能的疾病条件下出现的细胞和动物模型和系统生物学,化学,蛋白质组学和基因组学的技术进步。该计划将包括来自该领域的杰出调查人员,早期职业独立调查人员和新调查人员的演讲。在这次会议的历史上,第一次戈登凯南研究研讨会(GRS)的基质金属蛋白酶将由博士后研究员和研究生与金属蛋白酶研究的兴趣。GRS将为年轻的研究人员提供一个独特而令人兴奋的论坛,以展示他们的研究和发现GRC的经验。全球遥感系统期间的活动将侧重于:(1)为初级研究者提供学习和讨论MMPs在疾病中的常见机制和作用的基本背景的机会,以最大限度地提高他们对将在随后的GRC中讨论的科学的理解,(2)从该领域的同行和专家那里获得关于他们正在进行的研究项目的反馈,并与他们讨论他们的想法,及(3)促进他们与科学界资深成员的互动,以促进他们的专业发展。我们完全预计,2011年和未来的MMP GRC和GRS与会者之间的科学讨论、研究讲座、海报会议和其他非正式互动将延续这些独特会议的传统,推进我们对金属蛋白酶功能的理解,将其转化为人类疾病的新型治疗干预措施。
公共卫生关系:戈登基质金属蛋白酶研究会议成立于1993年,是金属蛋白酶领域最负盛名的科学会议,金属蛋白酶是一组参与许多人类疾病发病机制的酶。该会议提供了一个论坛,介绍最新进展的前沿金属蛋白酶研究,并教育新一代的年轻研究人员感兴趣的领域。预计本次会议的传统特点是合议和合作的气氛将为涉及金属蛋白酶活性失调的人类疾病的新型疗法的智力开发和实施提供完美的环境。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rafael A. Fridman其他文献
Rafael A. Fridman的其他文献
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{{ truncateString('Rafael A. Fridman', 18)}}的其他基金
Novel approach for inhibition of MT1-MMP/gelatinase axis
抑制 MT1-MMP/明胶酶轴的新方法
- 批准号:
7087070 - 财政年份:2003
- 资助金额:
$ 0.3万 - 项目类别:
Novel approach for inhibition of MT1-MMP/gelatinase axis
抑制 MT1-MMP/明胶酶轴的新方法
- 批准号:
6913692 - 财政年份:2003
- 资助金额:
$ 0.3万 - 项目类别:
Novel approach for inhibition of MT1-MMP/gelatinase axis
抑制 MT1-MMP/明胶酶轴的新方法
- 批准号:
6600235 - 财政年份:2003
- 资助金额:
$ 0.3万 - 项目类别:
Novel approach for inhibition of MT1-MMP/gelatinase axis
抑制 MT1-MMP/明胶酶轴的新方法
- 批准号:
6733535 - 财政年份:2003
- 资助金额:
$ 0.3万 - 项目类别:
SURFACE BINDING AND ACTIVATION OF MMP9 IN TUMOR CELLS
肿瘤细胞中 MMP9 的表面结合和激活
- 批准号:
6173604 - 财政年份:1999
- 资助金额:
$ 0.3万 - 项目类别:
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