A Pilot Study of Positively Smoke Free on the Web (PSFW) for HIV-infected Smokers

针对感染艾滋病毒的吸烟者的网上积极无烟 (PSFW) 试点研究

• 批准号: 8210239
• 负责人: CASSANDRA A STANTON
• 金额: $ 23.57万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-27 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8210239
• 关键词: AIDS-Related Opportunistic Infections; Abstinence; Address; Adherence; Aging; Alcohol consumption; American; Automobile Driving; Caring; Cessation of life; Clinical; Communities; Comorbidity; Computer Literacy; Data; Death Rate; Drug usage; Economics; Elements; Epidemic; Feedback; Foundations; Funding; Goals; HIV; Health; Health Priorities; Highly Active Antiretroviral Therapy; Internet; Intervention; Life; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Measures; Modeling; Morbidity - disease rate; New York City; Online Systems; Opportunistic Infections; Participant; Persons; Pilot Projects; Population; Prevalence; Provider; Psychologist; Public Health; Randomized; Randomized Controlled Trials; Relative (related person); Research; Resources; Role; Route; Services; Side; Smoke; Smoker; Smoking; Smoking Behavior; Smoking Cessation Intervention; Social support; Sorting - Cell Movement; Specialist; Surveys; Technology; Testing; Time; Tobacco; Tobacco Use Cessation; Tobacco use; Translating; United States National Institutes of Health; United States Public Health Service; Visit; Vulnerable Populations; Writing; cigarette smoking; cohort; comparative efficacy; cost; deprivation; design; digital; evidence base; health disparity; health organization; improved; interest; meetings; mortality; primary outcome; programs; prospective; psychosocial; satisfaction; smoking cessation; standard care; success; therapy design; treatment strategy; trial comparing; web page; web site

DESCRIPTION (provided by applicant): There are 1.1 million persons living with HIV (PLWH) in the US, 60% of them smoke cigarettes, and 75% of them are interested in quitting. Two-thirds of them use the internet. Almost none are currently accessing smoking cessation interventions designed to meet their specific needs and concerns. Cigarette smoking is responsible for 24% of deaths among PLWH, and 30% of non-AIDS defining malignancies. It is driving the alarming rise in lung cancers in this highly vulnerable population. The lack of access to proven, effective, culturally appropriate tobacco cessation services represents a health disparity of the first order. The psychosocial profile of the PLWH-smoker community, characterized by high rates of psychiatric comorbidity, drug and alcohol use, and low levels of social support, suggests that achieving high cessation rates will be a great challenge. Positively Smoke Free on the Web is the first web-based cessation program developed expressly for PLWH smokers. It is a resource that is ready for clinical use, but its feasibility and efficacy have yet to be studied. The main goals of this proposal are (1) to evaluate the website's feasibility (i.e. recruitment, adherence, retention, and satisfaction) in a cohort of 69 PLWH smokers, and (2) to complete a prospective, randomized controlled trial comparing the efficacy of the online program to standard care (total N=138) with a primary outcome of 3 month point-prevalence abstinence. If the program is proven to be efficacious, the project will have short term impact by offering a broadly available, free option for tobacco treatment to an underserved, high-priority population, and by informing further research on the optimization of web-based treatment for PLWH smokers. The long-term impact will be reduced tobacco-related morbidity and mortality among PLWH, and a clearer understanding of the role of targeted, web-based health interventions in comprehensive HIV care. PUBLIC HEALTH RELEVANCE: The epidemic of cigarette smoking is fueling an alarming rise in lung and other cancers in persons living with HIV. Smokers living with HIV have few, if any, cessation resources available to them that address their particular needs, and HIV care providers have virtually no evidence base to guide their approach to tobacco treatment. The proposal, if funded, will attempt to address this major public health issue by harnessing the enormous reach and power of the internet.

描述（由申请人提供）：美国有110万艾滋病毒感染者（PLWH），其中60%吸烟，其中75%有戒烟的兴趣。其中三分之二的人使用互联网。目前，几乎没有人能够获得旨在满足其特定需求和关切的戒烟干预措施。吸烟导致24%的艾滋病患者死亡，30%的非艾滋病恶性肿瘤。它正在推动这一高度脆弱人群中肺癌发病率的惊人上升。缺乏获得经证实的、有效的、在文化上适当的戒烟服务的机会是首要的健康差距。plwh吸烟者社区的社会心理状况，其特点是精神合并症、药物和酒精使用率高，社会支持水平低，这表明实现高戒烟率将是一个巨大的挑战。积极无烟网络是第一个基于网络的戒烟计划开发明确为PLWH吸烟者。这是一种可供临床使用的资源，但其可行性和有效性还有待研究。该提案的主要目标是(1)评估网站在69名PLWH吸烟者队列中的可行性（即招募，依从性，保留性和满意度），以及(2)完成一项前瞻性随机对照试验，比较在线计划与标准治疗的疗效（总N=138），主要结果为3个月的点流行戒烟。如果该计划被证明是有效的，该项目将产生短期影响，为服务不足的高优先人群提供广泛可用的免费烟草治疗选择，并为进一步研究优化基于网络的PLWH吸烟者治疗提供信息。长期影响将是减少艾滋病毒感染者中与烟草有关的发病率和死亡率，以及更清楚地了解有针对性的、基于网络的卫生干预措施在艾滋病毒综合护理中的作用。