SUD & Decision-Making: A Pilot Imaging Study of Parents & Children

南德

• 批准号: 8177979
• 负责人: Christina W. Hoven
• 金额: $ 19.96万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8177979
• 关键词: 15 year old; Acceleration; Adolescent; Adult; Affect; African American; Age; Alcohol or Other Drugs use; Amygdaloid structure; Anterior; Behavior; Behavioral; Brain; Brain imaging; Child; Child Abuse; Collaborations; Communities; Complex; Conflict (Psychology); Coupled; Coupling; Criminal Justice; Data; Decision Making; Diagnosis; Early identification; Emotional; Epidemiologic Studies; Epidemiology; Exhibits; Family; Family history of; Fathers; Functional Magnetic Resonance Imaging; Future; Gender; Hispanics; Image; Impairment; Imprisonment; Individual; Intervention; Investigation; Justice; Maintenance; Measures; Minority; Mothers; Parents; Participant; Pathway interactions; Pattern; Performance; Pilot Projects; Prefrontal Cortex; Preventive; Procedures; Process; Psychopathology; Reaction Time; Recording of previous events; Recruitment Activity; Regulation; Research; Research Personnel; Resolution; Risk; Role; Science; Signal Transduction; Stress; Substance Use Disorder; System; Time; Ventral Striatum; base; cingulate cortex; cognitive control; conflict resolution; design; discounting; early adolescence; executive function; high risk; lifetime risk; neural circuit; neurobehavioral; neuroimaging; neuropsychiatry; offspring; relating to nervous system; response; transmission process

DESCRIPTION (provided by applicant): There is mounting evidence from behavioral and neuroimaging studies that specific impairments in executive functioning are key hallmarks of the initiation and maintenance of Substance Use Disorders (SUD). This proposal is for a Pilot neuroimaging study which aims to determine the feasibility and establish parameters for a Full-Scale study which will investigate the behavioral and neural correlates of decision making and cognitive control in order to identify markers of vulnerability to Substance Use Disorders (SUDs). We propose a collaboration involving a highly accomplished interdisciplinary team including child psychiatric epidemiology, neuroimaging, decision science, child and adolescent neuropsychiatry, and substance use disorders researchers. This Pilot study draws on two ongoing longitudinal psychiatric epidemiological studies (N=1,120), one of mothers involved with the criminal justice system (CJS) (N=580; 5RO1 DA23733: Maternal Incarceration and Course of Child Psychopathology: PI: Hoven) and another of fathers involved with the criminal justice system and their children (N=580; 5R01DA024029; Paternal Criminal Justice Involvement and Substance Use in Children & Adolescents: PI: Hoven)). Each study has a matched child control based on age and gender. The proposed Pilot study will recruit mothers and fathers with and without SUD and their 12 - 15 year old children (total N=48). In parent-child dyads, we will examine three domains in which there is evidence for deficits in SUD individuals: 1) cognitive control over emotional conflict, as measured by the Emotional Conflict Resolution Task, 2) cognitive control in intertemporal choices, as measured by the Intertemporal Choice Task, and 3) decision making under risk, as measured by the Columbia Card Task. By using these tasks together, and studying parents and their children simultaneously, we will be able to thoroughly characterize multilevel decisional profiles and their underlying neurocircuitry that might differentiate parents with and without SUD, and children with positive and negative family histories of SUD. Therefore, findings from this research could have significant impact on future strategies for early identification of vulnerable adolescents, and for developing preventive and treatment interventions for SUD based on specific neurobehavioral mechanisms. PUBLIC HEALTH RELEVANCE: This Pilot is designed to provide the basis of conducting a full scale investigation that will allow for the advancement of science by examining the relationship between decision making, SUD and adolescent brain circuitry, through brain imaging and epidemiology, building upon a large, longitudinal investigation of parents involved with the criminal justice system and their children.

描述（由申请人提供）：行为和神经影像学研究中有越来越多的证据表明，执行功能的特定损伤是物质使用障碍（SUD）开始和维持的关键标志。该提案是一项先导性神经影像学研究，旨在确定可行性并建立全规模研究的参数，该研究将调查决策和认知控制的行为和神经相关性，以确定易受物质使用障碍（SUD）影响的标志物。我们提出了一个合作，涉及一个非常有成就的跨学科团队，包括儿童精神病学，神经影像学，决策科学，儿童和青少年神经精神病学，和物质使用障碍的研究人员。这项试点研究借鉴了两项正在进行的纵向精神病学流行病学研究（N= 1，120），其中一项是涉及刑事司法系统（CJS）的母亲（N=580; 5 RO 1 DA 23733：母亲监禁和儿童精神病理学过程：PI：Hoven）和另一个涉及刑事司法系统及其子女的父亲（N=580; 5 R 01 DA 024029;儿童和青少年的父亲刑事司法参与和药物使用：PI：Hoven））。每项研究都有一个基于年龄和性别的匹配儿童对照。拟议的初步研究将招募患有和不患有SUD的母亲和父亲及其12 - 15岁的子女（总N=48）。在亲子配对中，我们将研究三个领域，其中有证据表明SUD个体存在缺陷：1）情绪冲突的认知控制，如情绪冲突解决任务所测量的，2）跨期选择的认知控制，如跨期选择任务所测量的，3）风险下的决策，如哥伦比亚卡片任务所测量的。通过一起使用这些任务，并同时研究父母和他们的孩子，我们将能够彻底描述多层次的决策概况及其潜在的神经回路，这可能会区分父母与非SUD，以及有SUD阳性和阴性家族史的儿童。因此，这项研究的结果可能会对未来的策略产生重大影响，早期识别脆弱的青少年，并制定预防和治疗SUD基于特定的神经行为机制的干预措施。 公共卫生相关性：该试点项目旨在提供进行全面调查的基础，通过脑成像和流行病学，在对参与刑事司法系统的父母及其子女进行大型纵向调查的基础上，研究决策、SUD和青少年脑回路之间的关系，从而促进科学进步。