Multidisciplinary Training in Environmental Toxicology

描述（由申请人提供） MSU的多学科环境和综合毒理学科学（EITS）培训计划培养了具有环境毒理学基础知识的科学家，以及在生物医学基础科学研究生课程中获得的研究专业知识。博士预科生必须符合博士学位。满足他们“家乡”生物医学博士项目的要求，并完成通过综合毒理学中心（CIT）管理的EITS博士项目的课程、研究和互动方面。 培训的双重性质在授予学位的生物医学科学-环境毒理学标题中得到承认（例如，博士《生物化学与分子生物学-环境毒理学》）。该计划的毕业生有能力进行研究，并在解决复杂的环境毒理学问题，需要协作，多学科的方法过程中与其他科学家互动。 20个培训教师在7个基础科学博士进行博士前培训。课程（药理学/毒理学，遗传学，生物化学和分子生物学，食品科学，细胞和分子生物学，比较医学和综合生物学，微生物学和分子遗传学）。 除了基本的生物医学科学教育和环境毒理学研究培训外，还有教学，毒理学导向的课程和EITS计划的其他要求。这门课程和CIT提供的不太正式的多学科互动和活动传授了比基础科学课程更广泛的知识。 学员的研究课题涵盖各种器官系统，包括基因与环境的相互作用以及环境因素在疾病易感性和进展中的作用。有一个综合的生物学重点的研究培训，它强调整个动物，细胞为基础的，分子和基因组的方法，以了解在合作的气氛中的毒性机制。博士后培训计划不仅涉及在培训教师的实验室进行研究，而且还通过参与CIT和大学范围内的活动获得额外的环境毒理学经验和职业建设培训。该应用程序是六个博士前和三个博士后学员的支持，从而继续一个非常有效的多学科和互动的培训计划，结合正式和非正式的方法，准备毕业生在环境毒理学领域的研究领导作用。 背景 密歇根州立大学（MSU）的环境毒理学培训于1978年随着环境毒理学中心的成立而正式化。 该中心现在被称为综合毒理学中心（CIT）。 该计划的博士前学员获得了环境毒理学的基础知识，以及在生物医学基础科学研究生课程中获得的研究专业知识。博士预科生必须符合博士学位。他们的家庭生物医学博士课程的要求，并完成课程，研究和多学科环境和综合毒理学科学（EITS）培训计划的互动方面通过中心管理综合毒理学（CIT）。 培训的双重性质在授予学位的生物医学科学-环境毒理学标题中得到承认（例如，博士《生物化学与分子生物学-环境毒理学》）。 博士后学员通过参加CIT和大学范围内的活动获得额外的环境毒理学经验和职业建设培训。 该计划的毕业生似乎有能力进行研究，并在解决复杂的环境毒理学问题，需要协作，多学科的方法过程中与其他科学家互动。 目前，来自19个不同部门的约50名教师隶属于CIT，其中20名教师已被选中参加这一培训计划。 20名教师来自7个基础科学博士。课程（药理学/毒理学，遗传学，生物化学和分子生物学，食品科学，细胞和分子生物学，比较医学和综合生物学，微生物学和分子遗传学）。 学员的研究课题涵盖各种器官系统，包括基因与环境的相互作用以及环境因素在疾病易感性和进展中的作用。 这项申请是为了支持六名博士前和三名博士后学员，这与目前的支持水平相似。

DESCRIPTION (provided by applicant) The multidisciplinary Environmental and Integrative Toxicological Sciences (EITS) Training Program at MSU produces scientists having a base knowledge in environmental toxicology coupled with research expertise gained in a biomedical basic science graduate program. Pre-doctoral trainees must meet the full Ph.D. requirements of their "home" biomedical doctoral program and complete the coursework, research and interactive aspects of the EITS Doctoral Program administered through the Center for Integrative Toxicology (CIT). The dual nature of the training is recognized in the biomedical science-environmental toxicology title of the degree awarded (e.g., Ph.D. in "Biochemistry and Molecular Biology-Environmental Toxicology"). Graduates of the program are well equipped to conduct research and interact with other scientists in the course of solving complex environmental toxicological problems that require collaborative, multidisciplinary approaches. Twenty training faculty conduct pre-doctoral training in seven basic science Ph.D. programs (Pharmacology/Toxicology, Genetics, Biochemistry and Molecular Biology, Food Science, Cell and Molecular Biology, Comparative Medicine and Integrative Biology, Microbiology and Molecular Genetics). Added to the basic biomedical science-based education and environmental toxicology research training are didactic, toxicology-oriented courses and other requirements of the EITS Program. This coursework and less formal multidisciplinary interactions and activities provided by the CIT impart a wider scope of knowledge than is available within basic science programs alone. Research topics for trainees span various organ systems and encompass gene-environment interactions and the role of environmental factors in disease susceptibility and progression. There is an integrative biology emphasis to the research training, which emphasizes whole animal, cell-based, molecular and genomic methodologies to understand mechanisms of toxicity in a collaborative atmosphere. The postdoctoral training program involves not only conducting research in the laboratories of the training faculty but also gaining additional environmental toxicology experience and career-building training through participation in CIT and University-wide activities. This application is for support of six pre-doctoral and three postdoctoral trainees, thereby continuing a highly effective multidisciplinary and interactive Training Program that combines formal and informal approaches to prepare graduates for leadership roles in research in the field of environmental toxicology. BACKGROUND Training in environmental toxicology at Michigan State University (MSU) was formalized in 1978 with the establishment of the Center for Environmental Toxicology. This Center is now called the Center for Integrative Toxicology (CIT). Pre-doctoral trainees of the program receive a base knowledge in environmental toxicology coupled with research expertise gained in a biomedical basic science graduate program. Pre-doctoral trainees must meet the full Ph.D. requirements of their home biomedical doctoral program and complete the coursework, research and interactive aspects of the multidisciplinary Environmental and Integrative Toxicological Sciences (EITS) Training Program administered through the Center for Integrative Toxicology (CIT). The dual nature of the training is recognized in the biomedical science-environmental toxicology title of the degree awarded (e.g., Ph.D. in "Biochemistry and Molecular Biology-Environmental Toxicology"). The postdoctoral trainees gain additional environmental toxicology experience and career-building training through participation in CIT and University-wide activities. Graduates of the program appear to be well equipped to conduct research and interact with other scientists in the course of solving complex environmental toxicological problems that require collaborative, multidisciplinary approaches. Currently about 50 faculty from 19 different departments are affiliated with the CIT, and 20 of these faculty members have been selected for this Training Program. The 20 faculty members come from seven basic science Ph.D. programs (Pharmacology/Toxicology, Genetics, Biochemistry and Molecular Biology, Food Science, Cell and Molecular Biology, Comparative Medicine and Integrative Biology, Microbiology and Molecular Genetics). Research topics for trainees span various organ systems and encompass gene-environment interactions and the role of environmental factors in disease susceptibility and progression. This application is for support of six pre-doctoral and three postdoctoral trainees, which is similar to the current level of support.