Childhood Abuse and PTSD: Associations with Select Reproductive Outcomes

童年虐待和创伤后应激障碍：与特定生殖结果的关联

• 批准号: 8146131
• 负责人: Sabrina Charise Selk
• 金额: $ 2.72万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8146131
• 关键词: Address; Adolescence; Adolescent; Adult; Age; Awareness; Child; Child Abuse; Child Abuse and Neglect; Child Sexual Abuse; Childhood; Confounding Factors (Epidemiology); Data; Data Set; Development; Enrollment; Exposure to; Female; Future; Health; Health behavior; High Prevalence; Individual; Lead; Legal; Life; Life Cycle Stages; Link; Mental Health; Modeling; Nurses; Nurses' Health Study; Outcome; Outcomes Research; Pattern; Policy Maker; Post-Traumatic Stress Disorders; Pregnancy; Pregnancy Outcome; Pregnancy in Adolescence; Pregnancy loss; Premature Birth; Psychopathology; Quality of Care; Questionnaires; Reporting; Reproductive Health; Reproductive History; Research; Research Personnel; Risk; Role; Sample Size; Sampling; Second Pregnancy Trimester; Severities; Sexual abuse; Spontaneous abortion; Stress; Symptoms; Time; Violence; Woman; Work; abortion; base; burden of illness; cohort; early life exposure; emotional abuse; experience; maltreatment; meetings; physical abuse; prevention service; prospective; reproductive

To date, there is insufficient empirical evidence exploring the long term health consequences of childhood sexual abuse on adulthood reproductive health. Although negative health behaviors subsequent to the abuse and mental health correlates have been identified, the future health consequences are not as well understood. The purpose of this dissertation is to investigate the long term reproductive health outcomes associated with childhood exposures to physical, sexual, and emotional abuse. In order to examine this relationship, an observational dataset of a large cohort of female nurses, Nurses Health Study II, is being explored to see whether a relationship exists between childhood maltreatment and adult pregnancy outcomes, such as, preterm delivery and spontaneous abortion. Furthermore, the relationship of psychopathology to reproductive outcomes will be explored, by assessing the relationship between post-traumatic stress disorder (PTSD) symptoms with these pregnancy outcomes. Utilizing a life course model of health linking childhood exposures to adult health outcomes, this research will help explore the potential role of childhood abuse as an exposure with repercussions that last far beyond the immediate period of childhood and adolescence. There is a persistent and growing need for research to provide empirical evidence with regards to the possible long term health impacts related to childhood maltreatment. This research can be used to support the promotion of high quality care to meet the needs of children who have suffered maltreatment, as well as increasing awareness of the need for prevention services that will be of benefit not only to children, but may also serve to decrease the burden of disease across the life course.

迄今为止，没有足够的经验证据来探讨儿童性虐待对成年生殖健康的长期健康影响。尽管已经确定了虐待后的负面健康行为与心理健康的相关性，但未来的健康后果尚不清楚。本论文的目的是调查与儿童时期遭受身体、性和情感虐待相关的长期生殖健康结果。为了检验这种关系，正在探索一大群女护士的观察数据集“护士健康研究 II”，以了解儿童期虐待与成人妊娠结局（例如早产和自然流产）之间是否存在关系。此外，通过评估创伤后应激障碍（PTSD）症状与这些妊娠结局之间的关系，将探讨精神病理学与生殖结局的关系。这项研究利用将儿童期遭受虐待与成人健康结果联系起来的健康生命历程模型，将有助于探索儿童期虐待的潜在作用，因为这种暴露的影响远远超出了儿童期和青春期的直接时期。人们持续不断地需要不断增长的研究来提供有关儿童虐待可能对健康造成的长期影响的经验证据。这项研究可用于支持促进高质量护理，以满足遭受虐待的儿童的需求，并提高人们对预防服务需求的认识，这不仅对儿童有益，而且还可能有助于减轻整个生命过程中的疾病负担。