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Social and psychological risk for infectious illness

传染病的社会和心理风险

基本信息

批准号：
8118691
负责人：
SHELDON A COHEN
金额：
$ 5.52万
依托单位：
CARNEGIE-MELLON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-16 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8118691
关键词：
Address Adrenal hormone preparation Adult Affect Alcohol consumption Anti-Inflammatory Agents Anti-inflammatory Antibodies Attention Autonomic nervous system Behavior Behavioral Behavioral inhibition Biochemical Biological Biological Assay Blood Pressure Body Temperature Cellular Immunity Characteristics Chemicals Clinical Communicable Diseases Conflict (Psychology)Cotinine Data Delayed Hypersensitivity Demographic Factors Diet Disease Disease Resistance Disease susceptibility Drops Electronics Emotional Emotions Environment Environmental Risk Factor Equilibrium Event Goals Health Heart Rate Host resistance Hostility Hydrocortisone Hypothalamic structure Immune Immune response Immunity Individual Individual Differences Infection Inflammation Inflammatory Inflammatory Response Intake Intervention Interview Life Link Measurement Measures Mediating Mediator of activation protein Mitogens Modeling Molds Monitor Mucociliary Clearance Neurosecretory Systems Nicotine Nose Outcome Parasympathetic Nervous System Pathway interactions Peripheral Blood Mononuclear Cell Personality Persons Pharmacologic Substance Physical activity Physiological Pituitary Gland Play Predisposition Procedures Process Production Psychosocial Factor Quarantine Recovery Regulation Reporting Resistance to infection Resolution Rest Rhinovirus Risk Role Saliva Sampling Severity of illness Shyness Skin Sleep Smoking Social Environment Social Network Social support Stream Stress Symptoms System Techniques Technology Testing Time Upper Respiratory Infections Viral Virus Virus Diseases Virus Shedding Work behavior influence clinical Diagnosis cytokine design diaries disorder risk environmental intervention extravert heart rate variability immune function improved innovation interest interpersonal conflict introvert member novel physical conditioning pill prospective psychologic psychosocial respiratory respiratory infection virus response social trait

项目摘要

DESCRIPTION (provided by applicant): Our primary goals are to assess the influence of the social environment on susceptibility to upper respiratory illness and to identify the pathways through which environmental factors "get under the skin" to influence disease expression. We hypothesize that the social environment influences behavior, hypothalamic-pituitary-adrenocortical (HPA) and autonomic nervous system (ANS) responses which in turn influence the regulation of both cellular and humoral immune response to the virus. We use a unique prospective design. We first assess characteristics of the social environment and the status of behavioral and physiological systems we predict to link these characteristics to host resistance in 260 healthy adults who are seronegative for antibodies to the challenge virus. Subsequently, we expose each subject by intranasal drops to one of two strains of rhinovirus and monitor them closely for evidence of infection and illness in a cloistered environment. Measures of illness collected immediately before and daily during the cloister include virus shedding and titer, nasal pro-inflammatory, anti-inflammatory and anti-viral cytokine production, nasal and general symptoms, body temperature, nasal secretion production and nasal mucociliary clearance function. Using these data, we will determine if the social environment influences illness expression by altering baseline cellular immune status (delayed type hypersensitivity), Th-1/Th-2 cytokine balance, and the ability to produce pro-inflammatory cytokines (from mitogen stimulated peripheral blood mononuclear cells); whether it influences the regulation of cytokine production in response to the infection; and whether the association between the social environment and immunity are mediated by the ANS (separating sympathetic and parasympathetic contributions) and/or HPA systems. All analyses will control for demographic factors and will focus on whether the social environment predicts clinical illness (verified infection + clinical diagnosis). The results of this study will define the pathways by which one's social environment influences their susceptibility to upper respiratory virus infection and may identify potential targets for behavioral or pharmaceutical interventions to restore disease resistance in persons most at risk because of their social environments.

描述（由申请人提供）：我们的主要目标是评估社会环境对上呼吸道疾病易感性的影响，并确定环境因素“深入皮肤”影响疾病表现的途径。我们假设社会环境影响行为、下丘脑-垂体-肾上腺皮质（HPA）和自主神经系统（ANS）反应，进而影响对病毒的细胞和体液免疫反应的调节。我们采用独特的前瞻性设计。我们首先评估了社会环境的特征以及行为和生理系统的状态，我们预测将这些特征与 260 名挑战病毒抗体血清阴性的健康成年人的宿主抵抗力联系起来。随后，我们通过鼻内滴剂将每个受试者暴露于两种鼻病毒株中的一种，并在与世隔绝的环境中密切监测他们是否有感染和疾病的证据。在回廊前和每天在回廊期间收集的疾病指标包括病毒脱落和滴度、鼻促炎、抗炎和抗病毒细胞因子的产生、鼻和一般症状、体温、鼻分泌物产生和鼻粘膜纤毛清除功能。利用这些数据，我们将确定社会环境是否通过改变基线细胞免疫状态（迟发型超敏反应）、Th-1/Th-2细胞因子平衡以及产生促炎细胞因子（来自有丝分裂原刺激的外周血单核细胞）的能力来影响疾病表达；它是否影响响应感染的细胞因子产生的调节；以及社会环境和免疫之间的关联是否由 ANS（区分交感神经和副交感神经）和/或 HPA 系统介导。所有分析都将控制人口因素，并将重点关注社会环境是否可以预测临床疾病（已验证的感染+临床诊断）。这项研究的结果将确定一个人的社会环境影响其对上呼吸道病毒感染的易感性的途径，并可能确定行为或药物干预的潜在目标，以恢复因其社会环境而处于高危人群的疾病抵抗力。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cynical hostility relates to a lack of habituation of the cardiovascular response to repeated acute stress.

DOI：
10.1111/psyp.13681
发表时间：
2020-09
期刊：
Psychophysiology
影响因子：
3.7
作者：
A. Tyra;Ryan C. Brindle;B. Hughes;Annie T. Ginty
通讯作者：
A. Tyra;Ryan C. Brindle;B. Hughes;Annie T. Ginty

Childhood socioeconomic status, telomere length, and susceptibility to upper respiratory infection.

DOI：
10.1016/j.bbi.2013.06.009
发表时间：
2013-11
期刊：
BRAIN BEHAVIOR AND IMMUNITY
影响因子：
15.1
作者：
Cohen, Sheldon;Janicki-Deverts, Denise;Turner, Ronald B.;Marsland, Anna L.;Casselbrant, Margaretha L.;Li-Korotky, Ha-Sheng;Epel, Elissa S.;Doyle, William J.
通讯作者：
Doyle, William J.

Associations between adverse childhood family environments and blood pressure differ between men and women.

不良童年家庭环境与血压之间的关联在男性和女性之间存在差异。

DOI：
10.1371/journal.pone.0225544
发表时间：
2019
期刊：
PloS one
影响因子：
3.7
作者：
Schreier,HannahMC;Jones,EmilyJ;Nayman,Sibel;Smyth,JoshuaM
通讯作者：
Smyth,JoshuaM

Association between telomere length and experimentally induced upper respiratory viral infection in healthy adults.

DOI：
10.1001/jama.2013.613
发表时间：
2013-02-20
期刊：
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
影响因子：
120.7
作者：
Cohen, Sheldon;Janicki-Deverts, Denise;Turner, Ronald B.;Casselbrant, Margaretha L.;Li-Korotky, Ha-Sheng;Epel, Elissa S.;Doyle, William J.
通讯作者：
Doyle, William J.

Attachment Orientations, Respiratory Sinus Arrhythmia, and Stress Are Important for Understanding the Link Between Childhood Socioeconomic Status and Adult Self-Reported Health.

DOI：
10.1007/s12160-016-9842-4
发表时间：
2017-04
期刊：
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
影响因子：
0
作者：
Murdock KW;Fagundes CP
通讯作者：
Fagundes CP