Ovarian hormone regulation by extracellular matrix

细胞外基质对卵巢激素的调节

• 批准号: nhmrc : GNT0519367
• 负责人: Dr Helen Irving-Rodgers
• 金额: $ 19.21万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ovarian-hormone-regulation-extracellular-matrix/1344211
• 关键词: Ovarian; hormone; regulation; extracellular; matrix

Sex steroid hormones (e.g. oestrogen and testosterone), are important to male and female health. In the ovarian follicle I identified a novel form of extracellular matrix (focimatrix) which develops in the ovary before the synthetic enzymes needed for sex steroids are present. Using evidence from other tissues, I developed ideas on how this matrix regulates the enzymes for hormone synthesis. I will examine a mechanism by which focimatrix could directly affect steroid hormone production.

性类固醇激素（如雌激素和睾酮）对男性和女性的健康很重要。在卵泡中，我发现了一种新形式的细胞外基质（focimatrix），它在性类固醇所需的合成酶出现之前在卵巢中发育。利用来自其他组织的证据，我发展了关于这种基质如何调节激素合成酶的想法。我将研究focimatrix直接影响类固醇激素产生的机制。