Life Course Socioeconomics, Acculturation, & Type-2 Diabetes Risk Among Latinos

生命历程社会经济学、文化适应、

• 批准号: 8038521
• 负责人: Allison E Aiello
• 金额: $ 20.77万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8038521
• 关键词: Acculturation; Assimilations; Behavior; Behavioral; Biological; Biology; Characteristics; Chronic Disease; Cultural Characteristics; Development; Early treatment; Education; Generations; Health; Health behavior; Immigrant; Immune; Inflammation; Joints; Latino; Life; Life Cycle Stages; Mediating; Mediator of activation protein; Metabolic; Mind; Minority; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Occupations; Pattern; Population; Poverty; Public Health; Race; Research; Research Activity; Resources; Risk Factors; Socioeconomic Factors; Socioeconomic Status; Stress; diabetes risk; ethnic minority population; experience; inflammatory marker; intergenerational; skills; socioeconomics; transmission process

Latinos in the US carry a disproportionate burden of type-2 diabetes. Research has implicated life course socioeconomic position as a major factor in the development of chronic diseases, such as type-2 diabetes; yet most evidence is limited to non-Hispanic White populations. We hypothesize that the large disparities in type-2 diabetes among Latinos reflects the joint effect of intergenerational transmission of socioeconomic factors, cultural characteristics, behaviors, biology, and other risk factors accumulating over the life course. The experience of Latinos in the US represents an especially fruitful context in which to investigate the influence of life course socioeconomic and cultural resources in relation to type-2 diabetes. In addition to being the fastest growing minority population with high rates of obesity and type-2 diabetes, the experience of Latinos is one that includes first generation immigrants with limited education and job skills, and later generations who were born and raised in the US showing varying levels of acculturation and assimilation, behavioral change, and socioeconomic advancement. With these unique considerations in mind, the present study seeks to: (1) Examine the impact of life course socioeconomic position on type-2 diabetes among Latinos, (2) Assess whether acculturation modifies the impact of life course socioeconomic position on type-2 diabetes among Latinos, and 3) Examine whether metabolic, immune, and inflammatory markers related to health behaviors and stress mediate the relationships between life course socioeconomic position, acculturation and type-2 diabetes among Latinos. The proposed research activity will constitute the first systematic attempt to assess the unique and synergistic contributions of life course socioeconomic position and acculturation on type-2 diabetes among Latinos. By assessing life course exposures, this project provides an unprecedented opportunity to identify targets for early intervention for reducing the heavy burden of type-2 diabetes among Latinos in the US. More broadly, the proposed research may uncover crucial life course socioeconomic and cultural patterning of risk factors or health promoting characteristics that may also benefit other race/ethnic minorities disproportionately living in poverty and suffering from type-2 diabetes.

美国的拉丁裔人患2型糖尿病的负担不成比例。研究 社会经济地位作为发展的主要因素， 慢性疾病，如2型糖尿病;但大多数证据仅限于非西班牙裔 白色人口。我们假设，2型糖尿病的巨大差异， 拉丁裔反映了社会经济代际传递的共同作用 因素，文化特征，行为，生物学和其他风险因素积累 在生命历程中。拉丁美洲人在美国的经历代表了一种特别富有成效的 调查生命过程的社会经济和文化影响的背景 与2型糖尿病有关的资源。除了成为增长最快的少数民族 肥胖和2型糖尿病发病率高的人口，拉丁美洲人的经验是 其中包括教育和工作技能有限的第一代移民， 在美国出生和长大的后代， 文化适应和同化，行为改变和社会经济进步。 考虑到这些独特的因素，本研究试图：（1）审查 拉丁裔人生命过程中社会经济地位对2型糖尿病的影响，（2） 评估文化适应是否会改变生命历程社会经济地位的影响 2型糖尿病在拉丁美洲人，和3）检查是否代谢，免疫， 与健康行为和压力相关的炎症标志物介导了这种关系 生活过程中的社会经济地位，文化适应和2型糖尿病之间 拉丁裔。拟议的研究活动将是第一次系统性的尝试， 评估生命过程中社会经济地位的独特和协同作用 和文化适应对拉丁裔2型糖尿病的影响。通过评估生命历程 暴露，该项目提供了一个前所未有的机会，以确定目标， 早期干预，以减轻拉丁美洲人2型糖尿病的沉重负担， 我们更广泛地说，这项拟议中的研究可能会揭示关键的生命过程社会经济学 和风险因素或健康促进特征的文化模式， 使生活贫困和遭受贫困的其他种族/族裔少数群体受益 2型糖尿病