Neuroanatomical and behavioral anomalies in persistent developmental stuttering

持续性发育性口吃的神经解剖学和行为异常

• 批准号: 8019694
• 负责人: JOSEPH S PERKELL
• 金额: $ 16.8万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8019694
• 关键词: Accounting; Acoustics; Affect; Anisotropy; Area; Articulators; Auditory; Behavioral; Brain; Cerebral cortex; Clinical Research; Computer Simulation; Correlation Studies; Data; Development; Developmental Stuttering; Diffusion Magnetic Resonance Imaging; Disease; Emotions; Fingers; Image; Investigation; Jaw; Knowledge; Larynx; Lead; Left; Measurement; Measures; Modeling; Motor; Motor output; Movement; Persons; Population; Production; Property; Protocols documentation; Reaction Time; Running; Speech; Statistical Data Interpretation; Structure; Stuttering; System; Testing; Time; Time Study; Tongue; auditory feedback; base; behavior measurement; design; gray matter; improved; insight; kinematics; motor control; neuroimaging; novel; psychologic; relating to nervous system; response; social; theories; treatment effect; treatment program; vocal cord; white matter

This project aims to systematically investigate relationships between structural anomalies in brains of persons who stutter (PWS) and functional properties of the speech motor system. The project's approach builds on recent important findings regarding white matter (WM) irregularities and other neuroanatomical anomalies in PWS by attempting to identify behavioral (kinematic and acoustic) correlates of these anomalies during speech and other auditory-motor tasks, and by providing mechanistic interpretations of these findings within an established computational modeling framework of the neural bases of speech. The project is comprised of two inter-related experimental investigations that utilize structural neuroimaging in combination with behavioral measures to investigate theoretically motivated hypotheses concerning possible neural deficits underlying stuttering. The neuroimaging involves the use of magnetic resonance imaging and diffusion tensor imaging in PWS and matched fluent controls to obtain subject-specific measures of a set of candidate neuroanatomical markers (quantitative measures of structural properties of white and gray matter) derived from prior findings. The first investigation studies correlations between the neuroanatomical markers and behavioral measures reflecting feedforward motor control: kinematic and reaction-time (RT) data collected from the subject groups while they perform carefully designed, simple RT and speech tasks. The second investigation studies correlations between the neuroanatomical markers and the use of auditory feedback in speech: data collected on the subjects' responses to real-time spectral and temporal perturbations in the auditory feedback of their own speech. Both investigations will also test for differences in the measures between the groups of PWS and controls, and will consider alternative hypotheses. Establishing relations between behavioral and neuroanatomical anomalies in stuttering should provide new insights into important structural substrates that could lead to or potentiate the expression of underlying neurofunctional deficits. Different combinations of neuro-structural and neuro-functional factors could be manifested in a range of influences on stuttering, from emotions to malfunctions of movement triggering and timing.

该项目旨在系统地研究人类大脑结构异常之间的关系。 世界卫生组织口吃(PWS)和言语运动系统的功能特性。该项目的方法建立在 最近关于脑白质(WM)异常和其他神经解剖异常的重要发现 通过尝试识别语音过程中这些异常的行为(运动学和声学)关联 和其他听觉-运动任务，并通过在 建立了语音神经基础的计算建模框架。 该项目由两个相互关联的利用结构神经成像的实验研究组成。 与行为测量相结合，调查关于可能的理论动机的假设 口吃背后的神经缺陷。神经成像包括使用磁共振成像和 在PWS和匹配的FLUENT对照中进行扩散张量成像以获得一组受试者特定的测量 候选神经解剖学标记物(白质和灰质结构特性的定量测量) 从先前的发现中得出。第一项调查研究了神经解剖学标志物之间的相关性 反映前馈运动控制的行为测量：收集的运动学和反应时间(RT)数据 在他们执行精心设计的简单RT和语音任务时，从受试组中分离出来。第二 神经解剖标记物与听觉反馈使用的相关性研究 语音：收集的关于受试者对实时光谱和时间扰动的反应的数据 自己说话的听觉反馈。这两项调查还将测试这些措施的差异 在PWS组和对照组之间，并将考虑替代假设。 建立口吃的行为异常和神经解剖异常之间的关系应该会提供新的 对可能导致或增强潜在神经功能表达的重要结构底物的洞察 赤字。神经结构和神经功能因子的不同组合可以表现出来。 在一系列对口吃的影响中，从情绪到动作触发和计时的故障。