STANDARDIZED REHABILITATION THERAPY FOR ICU PATIENTS WITH ACUTE (TARGET)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在美国重症监护病房（ICU）每年收治的440万人中，需要机械通气的急性呼吸衰竭（ARF）影响了110万人。ARF患者会出现失调、肌无力、关节挛缩、呼吸困难、抑郁和健康相关生活质量下降，所有这些都可能导致住院时间延长和费用增加。ARF患者的危重病康复治疗内容不统一。拟议的研究将测试以下标准治疗假设：1）缩短ARF患者的住院时间; 2）将改善入组后6个月的客观功能指标和生活质量; 3）将减少炎症生物标志物; 4）将降低住院费用。我们将在326例ARF患者中进行一项两组随机试验，以比较标准化康复治疗。标准化康复治疗将包括：被动活动范围，物理治疗和渐进式抗阻运动。我们独特的环境提供了一个医院资助的，经验丰富的流动团队（7天/周），由一名重症监护护士，物理治疗师和护理助理组成，以管理此协议。拟议的研究是我们先前工作的自然延伸。 多学科方法（运动生理学，物理治疗，护理，医学，基础科学，健康经济学）得到初步研究的支持，并对最近的社会共识声明作出反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Acute Respiratory Failure (ARF) requiring mechanical ventilation affects 1.1 million of the 4.4 million people admitted to US Intensive Care Units (ICU) every year. Patients with ARF experience deconditioning, muscle weakness, joint contractures, dyspnea, depression, and reduced health-related quality of life, all of which may contribute to prolonged hospitalization and increased costs. Critical care rehabilitative therapy for patients with ARF is not uniform in its content. The proposed study will test the following standard therapy hypotheses: 1) shorten hospital stay in patients with ARF; 2) will improve objective functional measures and quality of life at 6 months post-enrollment; 3) will reduce biomarkers of inflammation; 4) will decrease hospital costs. We will conduct a two-arm, randomized trial in 326 patients with ARF to compare Standardized Rehabilitation Therapy. Standardized Rehabilitation Therapy will consist of: passive range of motion, physical therapy and progressive resistance exercise. Our unique environment provides a hospital-funded, experienced Mobility Team (7days/week) consisting of a critical care nurse, physical therapist and nursing assistant to administer this protocol. The proposed study is a natural extension of our prior work. Multidisciplinary approach(Exercise Physiology, Physical Therapy, Nursing, Medicine, Basic Science, Health Economics)is supported by preliminary studies and is responsive to recent society consensus statements.