GENETIC PREDISPOSITION TO TRANSIENT ADRENAL DYSFUNCTION IN SEVERE SEPSIS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。严重到足以引起低血压的感染是一种炎症状态，称为严重脓毒症。严重脓毒症患者可出现肾上腺衰竭。肾上腺功能不全被认为会导致低血压（休克）。ACTH是一种激素，已被用来测试肾上腺功能。目前，从医学文献中还不清楚使用哪个剂量的ACTH来评估肾上腺功能。为了找到最佳剂量，当严重脓毒症患者处于（1）休克时，（2）从休克中恢复后立即，（3）然后再次作为门诊病人时，将给予几种FDA批准的ACTH剂量。我们将测试是否有遗传倾向发展休克。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Infection severe enough to cause low blood pressure is an inflammatory state which is called severe sepsis. Patients with severe sepsis can have adrenal gland failure. Adrenal gland insufficiency is believed to lead to low blood pressure (shock). ACTH is a hormone that has been used to test adrenal function. Currently, it is unclear from the medical literature which dose of ACTH to use to evaluate adrenal function. To find the best dose, several FDA-approved doses of ACTH will be given when the severe sepsis patient is in (1) shock, (2) immediately after recovery from shock, and (3) then again as an outpatient. We will test whether there is a genetic predisposition to develop shock.