PATIENT OUTCOMES 6 AND 12 MONTHS AFTER ALTA, EDEN AND OMEGA ARDS NETWORK TRIAL

ALTA、EDEN 和 OMEGA ARDS 网络试验后 6 个月和 12 个月的患者结果

• 批准号: 8167040
• 负责人: PETER E MORRIS
• 金额: $ 0.75万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167040
• 关键词: Affect; Clinical Trials; Cognition; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Health Status; Incidence; Institution; Longitudinal Studies; Mental Health; Morbidity - disease rate; Outcome; Parents; Patients; Populations at Risk; Research; Research Personnel; Resources; Source; Survivors; Testing; United States National Institutes of Health; aging population; base; improved; mortality; muscle strength; research clinical testing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The incidence of ALI is higher than previously recognized and the number of survivors is growing due to improving ICU mortality and an aging population at risk for ALI. However, these survivors endure many long-term morbidities. To date, the vast majority of clinical trials in ALI have not considered these long-term outcomes, instead focusing exclusively on short-term mortality-based end points. To advance this field, larger-sized longitudinal studies are needed to comprehensively understand the long-term physical, cognitive and mental health status of survivors and to test how specific ICU therapies may affect these outcomes. Our proposal makes the following important contribution: in-depth clinical evaluation of muscle strength, anthropometrics and cognition which have been incompletely evaluated in prior studies but are likely commonly and severely impaired in survivors, and potentially improved by the ICU therapies tested in the parent trials.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 ALI的发病率比以前认识到的要高，由于ICU死亡率的提高和面临ALI风险的老龄化人口，幸存者的数量正在增加。然而，这些幸存者忍受着许多长期的疾病。到目前为止，ALI中的绝大多数临床试验都没有考虑这些长期结果，而是只关注基于死亡率的短期终点。为了推动这一领域的发展，需要进行更大规模的纵向研究，以全面了解幸存者的长期身体、认知和心理健康状况，并测试具体的ICU治疗可能如何影响这些结果。我们的建议做出了以下重要贡献：对肌肉力量、人体测量学和认知的深入临床评估，这些在以前的研究中得到了不完全的评估，但在幸存者中可能普遍和严重受损，并可能通过在父母试验中测试的ICU治疗而得到改善。