PATIENT OUTCOMES 6 AND 12 MONTHS AFTER ALTA, EDEN AND OMEGA ARDS NETWORK TRIAL

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 ALI 的发病率比以前认识的要高，并且由于 ICU 死亡率的提高和面临 ALI 风险的人口老龄化，幸存者人数正在增加。然而，这些幸存者承受着许多长期的疾病。迄今为止，绝大多数 ALI 临床试验并未考虑这些长期结果，而是仅关注基于短期死亡率的终点。为了推进这一领域的发展，需要进行更大规模的纵向研究，以全面了解幸存者的长期身体、认知和心理健康状况，并测试特定的 ICU 疗法如何影响这些结果。我们的建议做出了以下重要贡献：对肌肉力量、人体测量学和认知进行深入的临床评估，这些在之前的研究中尚未得到完整评估，但在幸存者中可能普遍且严重受损，并且可能通过母体试验中测试的 ICU 疗法得到改善。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The incidence of ALI is higher than previously recognized and the number of survivors is growing due to improving ICU mortality and an aging population at risk for ALI. However, these survivors endure many long-term morbidities. To date, the vast majority of clinical trials in ALI have not considered these long-term outcomes, instead focusing exclusively on short-term mortality-based end points. To advance this field, larger-sized longitudinal studies are needed to comprehensively understand the long-term physical, cognitive and mental health status of survivors and to test how specific ICU therapies may affect these outcomes. Our proposal makes the following important contribution: in-depth clinical evaluation of muscle strength, anthropometrics and cognition which have been incompletely evaluated in prior studies but are likely commonly and severely impaired in survivors, and potentially improved by the ICU therapies tested in the parent trials.