EVALUATION OF SYSTEMIC HYPOTHERMIA INITIATED AFTER 6 HOURS OF AGE IN INFANTS

婴儿出生 6 小时后开始评估全身体温过低

• 批准号: 8166623
• 负责人: KRISTI L. WATTERBERG
• 金额: $ 0.87万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166623
• 关键词: Age; Animals; Blood flow; Body Temperature; Brain; Brain Injuries; Cessation of life; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Disabled Persons; Evaluation; Funding; Grant; Hospitals; Hour; Human; Infant; Infection; Institution; Newborn Infant; Organ; Outcome; Oxygen; Placenta; Research; Research Personnel; Resources; Risk; Safety; Source; Umbilical cord structure; United States National Institutes of Health; handicapping condition; improved; induced hypothermia; infant outcome; natural hypothermia; neonatal hypoxic-ischemic brain injury

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research is studying induced hypothermia in newborns after 6 hours of age to reduce death and improve outcomes of infants with Hypoxic-Ischemic Encephalopathy [HIE]. HIE results from decreased blood flow and oxygen to all organs in the body including the brain (caused by infections or placenta/umbilical cord problems). The risk of death or handicaps in infants who survive HIE is 50%. Presently, infants diagnosed with HIE less than six hours of age are cooled to decrease their body temperature 91.4-93.2 degrees F for 72 hours. Previous animal and human research has shown that induced hypothermia appears to be the most promising treatment to protect babies brains. Safety information in newborn babies cooled in their first 72 hours have shown no bad effects. Information suggests brain injury occurs over days to weeks following HIE. It is unknown if induced hypothermia is beneficial if started at a later age [after 6 hours]. Some infants with HIE have not yet arrived at a hospital where induced hypothermia is offered, or may not show signs of HIE until after they are 6 hours old. It is also unknown if a longer period of induced hypothermia [more than 72 hours] may be beneficial. The purpose of this study is to evaluate whether induced hypothermia begun between 6 and 24 hours of age and continuing 96 hours in infants who were born within 4 weeks of their due date and who show signs of HIE will reduce death and improve outcomes at 18 months.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究正在研究在 6 小时后对新生儿进行诱导低温治疗，以减少死亡并改善患有缺氧缺血性脑病 [HIE] 的婴儿的预后。 HIE 是由于包括大脑在内的身体所有器官的血流量和氧气减少（由感染或胎盘/脐带问题引起）造成的。 HIE 幸存婴儿的死亡或残疾风险为 50%。 目前，被诊断出患有 HIE 的婴儿出生后不到 6 小时，会被冷却 72 小时，将体温降低到 91.4-93.2 华氏度。 此前的动物和人类研究表明，诱导低温似乎是保护婴儿大脑最有希望的治疗方法。新生儿 72 小时内冷藏的安全信息显示没有不良影响。 有信息表明，HIE 后数天至数周内会发生脑损伤。 如果在较晚的年龄（6 小时后）开始诱导低温是否有益，目前尚不清楚。 一些患有 HIE 的婴儿尚未到达提供诱导低温的医院，或者可能直到 6 小时大后才表现出 HIE 迹象。 较长时间的诱导低温（超过 72 小时）是否有益尚不清楚。 本研究的目的是评估对于预产期 4 周内出生且表现出 HIE 迹象的婴儿，在 6 至 24 小时之间开始并持续 96 小时的诱导低温是否会减少死亡并改善 18 个月时的结局。