THE SURFACTANT POSITIVE AIRWAY PRESSURE AND PULSE OXIMETRY TRIAL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究提出了两个基本问题：早产儿的两种肺部治疗哪一种对婴儿更好？早产儿的肺部;早产儿血液中的适当氧气水平是多少。两种肺部治疗方法是“CPAP”（正压通气，以帮助保持肺部充气）和“插管”，在婴儿体内放置呼吸管？的气道与管理的表面活性剂通过这个呼吸管。 无论使用哪种治疗方法，所有需要呼吸帮助的婴儿都有患上一种称为“支气管肺发育不良”或“BPD”的慢性肺部疾病的风险。 自1990年以来，表面活性剂已可用于帮助早产儿呼吸更容易，但他们必须插管给予这种药物。 当婴儿无法通过呼吸室内空气获得足够的氧气进入他/她的血液时，也会给予氧气。 重要的是不要给太多的氧气，因为太多的氧气可能会导致一种称为“早产儿视网膜病”或“ROP”的眼病，这可能导致视力下降甚至失明。 在这项研究中，接受CPAP和有插管具体指南的婴儿将与出生后不久插管并给予表面活性剂的婴儿进行比较。该研究还比较了血液中氧气水平的较低范围（85-89%）和较高范围（91-95%）。 众所周知，较高的氧气范围与眼部疾病有关，然而，最安全的氧气范围仍然是未知的。 我们希望找出较低的范围是否会导致较低的ROP。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research asks two basic questions: which of two lung treatments in premature babies is better for the baby?s lungs; and what is the appropriate level of oxygen in premature infants blood. The two lung treatments are 'CPAP' (positive air pressure to help keep the lungs inflated) and 'intubation,' placement of a breathing tube in the infant?s airway with administration of surfactant through this breathing tube. Regardless of which treatment is used, all babies who need help with breathing are at risk of developing a type of chronic lung disease called 'Bronchopulmonary Dysplasia,' or 'BPD'. Since 1990, surfactant has been available to help premature babies breathe easier, but they must be intubated to give this medicine. Oxygen is also given whenever a baby is not able to get enough oxygen into his/her blood by breathing room air. It is important not to give too much oxygen because too much oxygen may cause an eye disease called 'Retinopathy of Prematurity,' or 'ROP,' that may result in poor vision or even blindness. In this study, infants who receive CPAP and who have specific guidelines for intubation will be compared to infants who are intubated and are given surfactant soon after birth. The study also compares a lower range (85-89%) and higher range (91-95%) of oxygen levels in the blood. It is known that higher oxygen ranges are associated with eye disease, however, the safest oxygen range is still unknown. We hope to find out if a lower range results in less ROP.