EARLY-ONSET SEPSIS AN NICHD/CDC SURVEILLANCE STUDY

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这是一项前瞻性队列研究。 将对在网络中心出生的被诊断为早发性脓毒症和/或脑膜炎的婴儿队列进行深入随访。 目的是： 1.确定分娩期预防性抗生素使用时期足月儿和早产儿中目前基于医院的EOS发生率。 2. 监测所有出生体重和胎龄的新生儿中与EOS和脑膜炎相关的微生物。 3. 通过孕龄和病原体比较无症状和有症状婴儿。 4. 按病原体组监测EOS婴儿败血症相关死亡率。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a prospective cohort study. The cohort of infants born at Network centers who are diagnosed to have early-onset sepsis and/or meningitis will be followed in depth. Aims are to: 1. To establish current hospital-based rates of EOS among term and preterm infants in the era of intrapartum antibiotic prophylaxis. 2. To monitor the organisms associated with EOS and meningitis in neonates of all birthweights and gestational ages. 3. To compare asymptomatic and symptomatic infants by gesational age and pathogen. 4. To monitor sepsis-associated mortality rates for infants with EOS, by pathogen group.