NEUROIMAGING AND NEURODEVELOPMENTAL OUTCOME: A SECONDARY TO SURFACTANT POSITIVE

神经影像和神经发育结果：表面活性剂阳性的次要结果

• 批准号: 8166606
• 负责人: KRISTI L. WATTERBERG
• 金额: $ 0.76万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166606
• 关键词: Age; Brain; Cephalic; Computer Retrieval of Information on Scientific Projects Database; Consent; Continuous Positive Airway Pressure; Enrollment; Environmental air flow; Funding; Grant; Hospitals; Institution; Magnetic Resonance Imaging; Modeling; National Institute of Child Health and Human Development; Neonatal; Outcome; Premature Infant; Randomized; Relative (related person); Research; Research Personnel; Resources; Risk Factors; Secondary to; Source; Time; United States National Institutes of Health; follow-up; neuroimaging; predictive modeling; programs; surfactant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Network - Antenatal Consent SUPPORT I C. Study Aim(s): 1) To obtain consistently performed, timed and interpreted neuroimaging studies in extremely preterm infants enrolled in SUPPORT: a. cranial US at 4-14 days of age b. cranial US at 35-42 weeks PMA c. MRI at 35-42 weeks PMA 2) To compare early and late US and MRI findings between Low and High SpO2 groups within each randomized ventilation strata, and between Early CPAP and Control ventilation groups within each randomized oxygenation strata. 3) To utilize the NICHD Neonatal Research Network follow-up programs to assess neurodevelopmental outcomes at 18-22 months corrected age, as described in SUPPORT. 4) To examine the independent associations of neuroimaging findings with neurodevelopmental outcomes through predictive modeling. a. Regression models will assess the absolute and relative value of early and late cranial US, and brain MRI, alone and in combination with traditional risk factors, to predict abnormal and normal neurodevelopmental outcome at 18-22 months. b. Through stepwise regression modeling, assess the value of neuroimaging findings, alone and in combination, in predicting neurodevelopmental outcomes over and above the value of early risk factors or early and in-hospital risk factors alone.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 网络 - 产前同意支持 I C. 研究目标： 1) 为了获得对参加 SUPPORT 的极早产儿进行一致执行、定时和解释的神经影像学研究： 一个。 4-14 日龄时的头颅超声检查 b. 35-42 周 PMA 时的头颅超声检查 c. 35-42 周 PMA 时的 MRI 2) 比较每个随机通气层中低 SpO2 组和高 SpO2 组之间以及每个随机氧合层中早期 CPAP 组和对照通气组之间的早期和晚期 US 和 MRI 结果。 3) 利用 NICHD 新生儿研究网络随访计划来评估 18-22 个月校正年龄的神经发育结果，如支持中所述。 4）通过预测模型检查神经影像学结果与神经发育结果的独立关联。 一个。回归模型将评估早期和晚期颅超声和脑 MRI 的绝对和相对价值，单独或与传统风险因素相结合，以预测 18-22 个月时的异常和正常神经发育结果。 b.通过逐步回归模型，评估 单独或组合的神经影像学发现在预测神经发育结果方面的价值超过了早期危险因素或单独的早期和院内危险因素的价值。