THE EFFECT OF PAIN ON LEUKOCYTE CAM EXPRESSION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标 虽然在急性炎症情况下有功能，但我们假设由强大而独特的疼痛应激源诱导的免疫反应对那些患有慢性炎症性疾病的患者具有重要的健康影响，包括动脉粥样硬化、炎症性肠病和类风湿性关节炎。了解疼痛对此类疾病的病理和症状的影响显然是一个值得护理研究的领域。为此，这项前期工作的具体目标是： 1通过一项正式的先导性研究，描述和比较健康男性和女性对照组在实验性疼痛应激条件下的特殊免疫和炎症系统反应(包括儿茶酚胺、细胞因子和细胞黏附分子的变化)。 2.为首席研究员开发一条新的调查路线，通过与全国公认的神经生理学家和免疫学家进行多学科合作，扩展她在疼痛生理学方面的专业知识，以包括疼痛对免疫和炎症参数的影响。 这项拟议的先导性研究将检验这一新观点，即疼痛作为一种独特的应激源，通过其增加CAM水平的作用，通过炎症过程产生有害影响。研究假设基于压力框架，在该框架中，疼痛被概念化为一种心理(情感)应激源和一种独特的伤害性(神经感觉)应激源，其影响在肾上腺素能标志物、细胞因子产生以及最终的CAM水平上明显。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS Although functional in the case of acute inflammation, we posit that the immune response induced by the potent and unique stressor of pain has important health implications for those patients with chronic inflammatory diseases, including atherosclerosis, inflammatory bowel disease, and rheumatoid arthritis. Understanding how pain may contribute to the pathology and symptomatology of such diseases is clearly an area worthy of nursing investigation. To this end, the specific aims of this preliminary work are to: 1 Via a formal pilot study, describe and compare the particular immune and inflammatory system responses (including changes in catecholamines, cytokines, and cellular adhesion molecules) in healthy male and female controls to experimental pain stress conditions. 2. Develop a new line of investigation for the principal investigator, who will expand her expertise in pain physiology to include the effects of pain on immune and inflammatory parameters, via multidisciplinary collaboration with nationally-recognized neurophysiologists and immunologists. The proposed pilot study will test the novel idea that pain, as a unique stressor, has detrimental effects via inflammatory processes via its effect on increasing CAM levels. Study hypotheses are based upon a stress framework, in which pain is conceptualized as both a psychological (affective) stressor and a uniquely nociceptive (neural-sensory) stressor, the effects of which are evident in adrenergic markers, cytokine production, and ultimately CAM levels.