QUANTIFICATION OF HUMAN OPIOID RESPONSE: PILOT STUDY

阿片类药物对人类中枢神经系统有已知的和可重复的影响，主要包括兴奋、欣快和镇痛。某些种类的动物模型已经被培育成对某些阿片激动剂和拮抗剂或多或少有反应，这表明人类阿片样物质的个体差异已经被记录下来。这些数据提出了一个问题：这些个体差异以何种方式（如果有的话）一方面与镇痛和致欣快反应有关，另一方面与慢性疼痛综合征或阿片类药物滥用的易感性有关？这项工作的最终目标是，在完成这个试点之后，了解中枢阿片类药物反应是否可以预测对疼痛和阿片类药物的异常反应，从而导致不适应的疼痛和成瘾反应。

Opioids have known and reproducible effects on the human central nervous system, which principally include miosis, euphoria and analgesia. That certain strains of animal models have been bred to relatively more or less responsive to certain opioid agonists and antagonists suggests that individual differences in human opioids in humans have been documented. These data raise the question: In what manner, if any, do these individual differences relate to analgesic and euphorigenic responses on one hand, and the susceptibility to chronic pain syndromes or to opioid abuse on the other? The ultimate goal of this work, beyond completion of this pilot, is to learn if central opioid responsivity can predict aberrant responses to pain and opioids that contribute to maladaptive pain and addiction responses.