QUANTIFICATION OF HUMAN OPIOID RESPONSE: PILOT STUDY

人类阿片类药物反应的量化：试点研究

• 批准号: 6265309
• 负责人: PEGGY COMPTON
• 金额: $ 0.19万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265309
• 关键词: analgesia; central nervous system; chronic pain; clinical research; clinical trial phase I; drug abuse; drug screening /evaluation; endogenous opioid; euphoria; human subject; stimulus /response

Opioids have known and reproducible effects on the human central nervous system, which principally include miosis, euphoria and analgesia. That certain strains of animal models have been bred to relatively more or less responsive to certain opioid agonists and antagonists suggests that individual differences in human opioids in humans have been documented. These data raise the question: In what manner, if any, do these individual differences relate to analgesic and euphorigenic responses on one hand, and the susceptibility to chronic pain syndromes or to opioid abuse on the other? The ultimate goal of this work, beyond completion of this pilot, is to learn if central opioid responsivity can predict aberrant responses to pain and opioids that contribute to maladaptive pain and addiction responses.

阿片类药物对人类中枢神经系统具有已知和可重复的作用，主要包括瞳孔缩小、欣快和镇痛。 某些品系的动物模型已被培育成对某些阿片激动剂和拮抗剂的反应相对或多或少，这表明人类阿片类药物在人类中的个体差异已被记录在案。这些数据提出了一个问题：如果有的话，这些个体差异一方面与镇痛和欣快反应有关，另一方面与慢性疼痛综合征或阿片类药物滥用的易感性有关，这些个体差异以何种方式有关？ 这项工作的最终目标，除了完成这项试点，是了解中枢阿片类药物反应是否可以预测对疼痛和阿片类药物的异常反应，这些反应导致适应不良的疼痛和成瘾反应。