THE EFFECT OF PAIN ON LEUKOCYTE CAM EXPRESSION

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 具体目标 虽然在急性炎症的情况下是功能性的，但我们认为，疼痛的强大和独特的应激源诱导的免疫反应对患有慢性炎症性疾病的患者具有重要的健康意义，包括动脉粥样硬化，炎症性肠病和类风湿性关节炎。了解疼痛如何可能有助于这些疾病的病理学和病理学，显然是一个值得护理研究的领域。为此，这项初步工作的具体目标是： 1通过正式的初步研究，描述并比较健康男性和女性对照组对实验性疼痛应激条件的特定免疫和炎症系统反应（包括儿茶酚胺、细胞因子和细胞粘附分子的变化）。 2.为主要研究者开发一条新的研究路线，主要研究者将通过与国家认可的神经生理学家和免疫学家的多学科合作，扩展她在疼痛生理学方面的专业知识，包括疼痛对免疫和炎症参数的影响。 拟议的初步研究将测试新的想法，即疼痛作为一种独特的应激源，通过其对增加CAM水平的影响，通过炎症过程产生有害影响。 研究假设是基于压力框架，其中疼痛被概念化为心理（情感）应激源和独特的伤害性（神经感觉）应激源，其影响在肾上腺素能标记物，细胞因子产生和最终CAM水平中是明显的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS Although functional in the case of acute inflammation, we posit that the immune response induced by the potent and unique stressor of pain has important health implications for those patients with chronic inflammatory diseases, including atherosclerosis, inflammatory bowel disease, and rheumatoid arthritis. Understanding how pain may contribute to the pathology and symptomatology of such diseases is clearly an area worthy of nursing investigation. To this end, the specific aims of this preliminary work are to: 1 Via a formal pilot study, describe and compare the particular immune and inflammatory system responses (including changes in catecholamines, cytokines, and cellular adhesion molecules) in healthy male and female controls to experimental pain stress conditions. 2. Develop a new line of investigation for the principal investigator, who will expand her expertise in pain physiology to include the effects of pain on immune and inflammatory parameters, via multidisciplinary collaboration with nationally-recognized neurophysiologists and immunologists. The proposed pilot study will test the novel idea that pain, as a unique stressor, has detrimental effects via inflammatory processes via its effect on increasing CAM levels. Study hypotheses are based upon a stress framework, in which pain is conceptualized as both a psychological (affective) stressor and a uniquely nociceptive (neural-sensory) stressor, the effects of which are evident in adrenergic markers, cytokine production, and ultimately CAM levels.