iThera Medical Multispectral Optoacoustic Tomography System for Full Body Molecular and Functional Small Animal Imaging

 描述（由申请人提供）：本申请的目的是为德克萨斯大学MD安德森癌症中心（MDACC）的基础和翻译研究人员提供能够促进和促进其癌症研究的小动物全身光声成像。iThera Medical多光谱光声断层扫描（MSOT）小动物成像系统可提供小鼠全身的多波长光声成像数据。相当数量的NIH资助的研究人员在MDACC合作，共同完成消除癌症的使命。这些研究者的研究重点跨越基础、转化和临床领域，因此他们中的许多人依赖于癌症的小鼠模型来弥合基于实验室的开发和临床实施之间的差距。具体而言，MSOT系统将为MDACC研究人员提供一个强大的新工具，用于分子探针和治疗方法的开发，原位或自发肿瘤模型中癌症生物学的研究以及治疗效果的纵向评估。目前，MDACC没有能够进行全身或原位/自发肿瘤成像的光声成像系统来对这些研究中使用的小鼠进行功能和分子成像。本申请的具体目的是获得iThera Medical MSOT系统，使MDACC研究人员能够在小鼠模型中进行研究，以提高对癌症的机制理解、诊断和治疗。主要研究者、关键人员和本申请中详细说明的所有其他用户完全有能力并致力于确保MSOT系统将成功纳入MDACC的小动物成像核心，并充分发挥其潜力。正如我们在本申请中强调的那样，目前MDACC有许多NIH资助的研究人员，他们将立即从MSOT系统的收购中受益，该系统为研究人员提供了必要的分子和功能成像能力。此外，MSOT系统将成为MDACC的小动物成像设施（SAIF）支持的小动物成像和治疗资源的一部分，SAIF是一种共享的机构资源，部分由我们的癌症中心支持赠款（#：P30 CA 16672; PI：R）支持。DePinho）。最后，尽管MDACC的大量研究人员将立即使用MSOT系统，但该技术也可以及时使德克萨斯州休斯顿德克萨斯医学中心其他七个主要医学研究机构的NIH资助的研究人员受益。

 DESCRIPTION (provided by applicant): The purpose of this application is to provide basic and translational investigators from the University of Texas MD Anderson Cancer Center (MDACC) with a small-animal, full-body optoacoustic imaging capable of facilitating and furthering their cancer research. The iThera Medical Multispectral Optoacoustic Tomography (MSOT) small-animal imaging system provides multi-wavelength optoacoustic imaging data throughout the full body of a mouse. A significant number of NIH-funded investigators work collaboratively at MDACC toward their common mission of eliminating cancer. The research foci of these investigators span basic, translational, and clinical domains, and therefore many of them rely on murine models of cancer to bridge the gap between laboratory-based development and clinical implementation. Specifically, the MSOT system will provide MDACC investigators with a powerful new tool toward development of molecular probes and therapeutics, the investigation of cancer biology in orthotopic or spontaneous tumor models, and longitudinal assessment of therapeutic efficacy. Currently, MDACC does not have an optoacoustic imaging system capable of full-body or orthotopic/spontaneous tumor imaging to conduct functional and molecular imaging of the mice used in these studies. The specific aim of this application is to acquire the iThera Medical MSOT system to enable MDACC investigators to conduct research in murine models for the purpose of improving the mechanistic understanding, diagnosis, and therapy of cancer. The principle investigator, key personnel, and all other users detailed in this application are fully able and committed to ensuring that the MSOT system will be successfully incorporated into MDACC's small-animal imaging core and leveraged to its full potential. As we highlight in this application, there are currently many NIH-funded investigators at MDACC who would significantly and immediately benefit from the acquisition of an MSOT system, which affords researchers with essential molecular and functional imaging capabilities. In addition, the MSOT system would become part of the small- animal imaging and therapy resources supported by MDACC's Small Animal Imaging Facility (SAIF), which is a shared institutional resource supported, in part, by our Cancer Center Support Grant (#: P30 CA16672; PI: R. DePinho). Lastly, although there are a significant number of investigators at MDACC who will utilize the MSOT system immediately, in time the technology could also benefit NIH-funded investigators at the other seven major medical research institutions at the Texas Medical Center in Houston, TX.