Molecular and Cellular Mechanisms of Tumor Development

描述（由申请人提供）：该计划旨在汇集威斯康星州大学一组优秀的基础癌症研究导师的专业知识，并提供当地接触转化医学的机会，以创建并正式制定基础癌症研究博士后培训计划。麦卡德尔癌症研究实验室在癌症生物学的创新和发现方面有着悠久而卓越的历史，是培训计划的合适学术和行政场所。UW Carbone综合癌症中心（UWCCCC）是第一个NCI指定的综合癌症中心之一，在过去的36年里一直得到CCSG的支持。它们共同构成了无与伦比的培训环境，并以致力于青年科学家的教育而闻名。培训师小组（来自13个部门的26名科学家）非常出色;这些教师培训了65名学术教授，50名专业科学家，39名制药工业科学家，一名期刊编辑和19名临床科学家。他们有着良好的资金记录（该小组今年获得了1400万美元的资助，以及800万美元的癌症研究专项资金）。这个群体的研究重点是不同的，虽然他们共同的癌症重点。模型系统包括乳腺、前列腺、皮肤、头颈部、结直肠、肝脏和造血系统肿瘤，其主题包括遗传易感性、信号通路、代谢作用、肿瘤微环境、表观遗传效应、协同遗传因子、免疫调节、DNA损伤以及微流体技术的发展，这些技术使培养技术和循环细胞捕获取得突破。该计划将由亚历山大博士（乳腺癌研究人员，希望学者在国防部乳腺癌研究计划的时代），在博士Shull（麦卡德尔实验室主任和UWCCCC副主任）的协助下领导。监督程序委员会的成员之间共享，汇集在一起，代表从基础，临床和翻译教师的观点。这个新的培训计划的目标有三个方面，1）在他们职业发展的关键阶段为博士后候选人提供更严格的支持，2）促进以少数民族和服务不足社区为重点的招聘活动，以及3）利用指导委员会和其他共同的培训责任来促进研究和临床教师之间的讨论和科学互动。参加培训方案的科学利益不仅延伸到由培训赠款资助的受训人员，而且延伸到参与实验室的其他博士后和博士前受训人员，为这一培训方案计划创造附加值。总之，该计划将在这个校园中独一无二，为优秀的年轻科学家提供癌症生物学培训的计划支持，并通过让这些受训人员与临床教师合作，促进联邦癌症研究计划的转化目标。 公共卫生相关性：此申请是为了支持威斯康星州大学癌症生物学的正式博士后培训计划，包括基础研究和转化临床医学的培训机会。博士后导师已从威斯康星州Carbone综合癌症中心的大学成员中招募，他们具有非凡的培训，发现和成就历史。该计划将为促进职业发展，提高学员群体的多样性，以及促进我们的基础和临床院系之间的研究讨论创造机会。

DESCRIPTION (provided by applicant): This program aims to draw together the expertise of a select group of outstanding basic cancer researcher mentors at the University of Wisconsin, with local opportunities for exposure to translational medicine, to create and formalize a program for post-doctoral training in basic cancer research. The McArdle Laboratory for Cancer Research has a long and remarkable history for innovation and discovery in cancer biology, and is an appropriate academic and administrative home for a training program. The UW Carbone Comprehensive Cancer Center (UWCCCC) was one of the first NCI-designated Comprehensive Cancer Centers and has received continuous CCSG support for the past 36 years. Together, they constitute an unparalleled training environment, with a reputation for commitment to the education of young scientists. The trainer group (26 scientists from 13 departments) is outstanding; these faculty members have trained 65 academic professors, 50 professional scientists, 39 pharmaceutical industry scientists, a journal editor and 19 clinical scientists. They have excellent funding track records (this group is supported by $14m total, and $8m dedicated cancer research funding this year). The research focus of this group is diverse, though they share a cancer emphasis. Model systems include breast, prostate, skin, head and neck, colorectal, liver and hematopoietic tumors, and their topics include genetic susceptibility, signaling pathways, the role of metabolism, tumor microenvironment, epigenetic effects, collaborating genetic factors, immune regulation, DNA damage, and the development of microfluidic technologies that enable breakthroughs of culture technique and circulating cell capture. The program will be led by Dr. Alexander (a breast cancer researcher, Era of Hope Scholar in the DOD Breast Cancer Research Program), with the assistance of Dr. Shull (Director of the McArdle Laboratory and Associate Director of the UWCCCC). Oversight is shared between members of a Program Committee, drawn together to represent viewpoints from basic, clinical and translational faculty members. The goal of this new Training Program is three-fold, 1) to provide more rigorous support of post-doctoral candidates during key phases of their career development, 2) to promote recruiting activities that focus on minority and under-served communities, and 3) to use the mentoring committee and other shared training responsibilities to catalyze discussion and scientific interaction between the research and clinical faculties. The scientific benefits of participation in the training program extends not only to the trainees funded by the training grant, but also to the other post-doctoral and pre- doctoral trainees within the participating laboratories, generating added value for this training program plan. In summary, this program will be unique on this campus for providing programmatic support for outstanding young scientists training in cancer biology, and for facilitating the translational goals of the Federal Cancer Research program, by engaging these trainees with the clinical faculty. PUBLIC HEALTH RELEVANCE: This application is for support of a formalized post-doctoral training program in cancer biology at the University of Wisconsin, to include opportunities for training in basic research and translational, clinical medicine. Post-doctoral mentors have been recruited from the membership of the University of Wisconsin Carbone Comprehensive Cancer Center who have a remarkable history of training, discovery and accomplishment. This program will generate opportunities for promoting career development, for enhancing the diversity of the trainee group, and for catalyzing research discussion between our basic and clinical faculties.