Molecular and Cellular Mechanisms of Tumor Development

描述(由申请者提供)：该项目旨在汇集威斯康星大学一批杰出的基础癌症研究导师的专业知识，并在当地提供接触转化医学的机会，以创建并正式确定基础癌症研究的博士后培训计划。McArdle癌症研究实验室在癌症生物学的创新和发现方面有着悠久而非凡的历史，是一个适合培训计划的学术和行政机构。威斯康星大学Carbone综合癌症中心(UWCCCC)是首批NCI指定的综合癌症中心之一，在过去的36年里一直得到CCSG的持续支持。他们共同构成了一个无与伦比的培训环境，以致力于年轻科学家的教育而闻名。培训师团队(来自13个系的26名科学家)表现突出；这些教员培养了65名学术教授、50名专业科学家、39名医药行业科学家、1名期刊编辑和19名临床科学家。他们有着良好的资助记录(这一群体总共得到了1400万美元的支持，今年还获得了800万美元的癌症研究专项资金)。这一群体的研究重点是不同的，尽管他们都强调癌症。模型系统包括乳腺、前列腺、皮肤、头颈部、结直肠、肝脏和造血肿瘤，其主题包括遗传易感性、信号通路、新陈代谢的作用、肿瘤微环境、表观遗传效应、协同遗传因素、免疫调节、DNA损伤，以及使培养技术和循环细胞捕获取得突破的微流体技术的发展。该项目将由Alexander博士(乳腺癌研究人员、国防部乳腺癌研究计划的希望时代学者)领导，Shull博士(McArdle实验室主任兼UWCCCC副主任)协助开展。监督由项目委员会的成员共享，该委员会聚集在一起代表基础、临床和翻译教员的观点。这一新培训计划的目标有三个方面，1)在博士后职业发展的关键阶段为他们提供更严格的支持，2)促进以少数族裔和服务不足社区为重点的招聘活动，3)利用指导委员会和其他共同的培训责任来促进研究和临床教师之间的讨论和科学互动。参与培训计划的科学收益不仅延伸到培训补助金资助的学员，也延伸到参与实验室内的其他博士后和博士后学员，为本培训计划产生附加值。总而言之，这个项目在这个校园里将是独一无二的，因为它为杰出的年轻科学家提供癌症生物学培训的计划支持，并通过让这些受训人员与临床教师合作来促进联邦癌症研究计划的翻译目标。 公共卫生相关性：这项申请是为了支持威斯康星大学癌症生物学的正式博士后培训计划，包括基础研究和转化临床医学方面的培训机会。从威斯康星大学Carbone综合癌症中心的成员中招募了博士后导师，他们在培训、发现和成就方面有着非凡的历史。这一计划将为促进职业发展创造机会，增强实习生群体的多样性，并促进我们基础和临床学院之间的研究讨论。

DESCRIPTION (provided by applicant): This program aims to draw together the expertise of a select group of outstanding basic cancer researcher mentors at the University of Wisconsin, with local opportunities for exposure to translational medicine, to create and formalize a program for post-doctoral training in basic cancer research. The McArdle Laboratory for Cancer Research has a long and remarkable history for innovation and discovery in cancer biology, and is an appropriate academic and administrative home for a training program. The UW Carbone Comprehensive Cancer Center (UWCCCC) was one of the first NCI-designated Comprehensive Cancer Centers and has received continuous CCSG support for the past 36 years. Together, they constitute an unparalleled training environment, with a reputation for commitment to the education of young scientists. The trainer group (26 scientists from 13 departments) is outstanding; these faculty members have trained 65 academic professors, 50 professional scientists, 39 pharmaceutical industry scientists, a journal editor and 19 clinical scientists. They have excellent funding track records (this group is supported by $14m total, and $8m dedicated cancer research funding this year). The research focus of this group is diverse, though they share a cancer emphasis. Model systems include breast, prostate, skin, head and neck, colorectal, liver and hematopoietic tumors, and their topics include genetic susceptibility, signaling pathways, the role of metabolism, tumor microenvironment, epigenetic effects, collaborating genetic factors, immune regulation, DNA damage, and the development of microfluidic technologies that enable breakthroughs of culture technique and circulating cell capture. The program will be led by Dr. Alexander (a breast cancer researcher, Era of Hope Scholar in the DOD Breast Cancer Research Program), with the assistance of Dr. Shull (Director of the McArdle Laboratory and Associate Director of the UWCCCC). Oversight is shared between members of a Program Committee, drawn together to represent viewpoints from basic, clinical and translational faculty members. The goal of this new Training Program is three-fold, 1) to provide more rigorous support of post-doctoral candidates during key phases of their career development, 2) to promote recruiting activities that focus on minority and under-served communities, and 3) to use the mentoring committee and other shared training responsibilities to catalyze discussion and scientific interaction between the research and clinical faculties. The scientific benefits of participation in the training program extends not only to the trainees funded by the training grant, but also to the other post-doctoral and pre- doctoral trainees within the participating laboratories, generating added value for this training program plan. In summary, this program will be unique on this campus for providing programmatic support for outstanding young scientists training in cancer biology, and for facilitating the translational goals of the Federal Cancer Research program, by engaging these trainees with the clinical faculty. PUBLIC HEALTH RELEVANCE: This application is for support of a formalized post-doctoral training program in cancer biology at the University of Wisconsin, to include opportunities for training in basic research and translational, clinical medicine. Post-doctoral mentors have been recruited from the membership of the University of Wisconsin Carbone Comprehensive Cancer Center who have a remarkable history of training, discovery and accomplishment. This program will generate opportunities for promoting career development, for enhancing the diversity of the trainee group, and for catalyzing research discussion between our basic and clinical faculties.