Training in Ophthalmic Statistical Genetics and Bioinformatics

眼科统计遗传学和生物信息学培训

• 批准号: 8075190
• 负责人: Hongzhe Lee
• 金额: $ 11.64万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8075190
• 关键词: Bioinformatics; Genetic; Training

DESCRIPTION (provided by applicant): The graduate groups in Epidemiology and Biostatistics (EB) and Genomics & Computational Biology (GCB), in conjunction with the Department of Ophthalmology, all of the University of Pennsylvania (Penn) School of Medicine, propose to develop a pre- and post-doctoral training program in ophthalmic statistical genetics and bioinformatics. Penn promotes an academic environment in which basic and clinical research are encouraged and viewed as attractive career paths for trainees. This program will attract trainees nationwide; graduates will be placed in other institutions nationwide, resulting in a high impact program. The training program will consist of core courses in statistical theory, statistical genetics, genomics, computational biology, and ophthalmic disorders; extensive independent readings; participation in journal clubs and research conferences focusing on ophthalmic statistical genetics and bioinformatics; research seminars in the EB, GCB, and Department of Ophthalmology, and closely mentored experiences in translational ophthalmic research. The program for pre-doctoral trainees will be four to five years in duration, with structure provided by the PhD degree program in Biostatistics managed by the EB and the PhD degree program in Genomics & Computational Biology managed by GCB; pre-doctoral trainees will enroll in one of these PhD programs. The two- to three-year post-doctoral program is designed for scientists with PhD-level training in statistical genetics, bioinformatics, and/or computational biology who seek training in the application of their discipline to ophthalmic diseases and for physicians with specialty training in ophthalmology who seek training in statistical genetics, bioinformatics, and/or computational biology. The program is designed to: 1) train rigorous and independent academic investigators able to use the range of approaches available in statistics, statistical genetics, computational biology, and bioinformatics to conduct translational research in ophthalmic disorders; 2) provide intensive, supervised research experiences with mentors in ophthalmic statistical genetics and bioinformatics; 3) strengthen the links between biostatistics, genomics, computational biology, bioinformatics, and ophthalmology: 4) and encourage translational ophthalmic research. When fully operational (year three and beyond of this training program), four fellowship slots will be awarded annually. Three fellowships will be awarded annually to pre-doctoral trainees and one fellowship will be awarded annually to a post-doctoral trainee. Strengths of the proposed program are: 1) the successful research training programs in the EB and GCB; 2) the availability of participating faculty in the EB, GCB, and Department of Ophthalmology, who provide expertise in a wide range of disciplines: 3) numerous research projects conducted within centers and institutes at Penn with which participating faculty are affiliated; and 4) the faculties' commitment to collaborative and multidisciplinary research and training. PUBLIC HEALTH RELEVANCE: There is a major national shortage of qualified scientists with the training needed to conduct rigorous research in ophthalmic statistical genetics and bioinformatics. As the genomic data become more complex, and as the questions become more sophisticated with the help of new technologies, multidisciplinary teams consisting of statistical geneticists, bioinformaticians, and ophthalmologists are needed to study eye-related complex traits. Such teams will be well-positioned to identify genetic variants and biological pathways for complex diseases such as diabetic retinopathy, glaucoma, macular degeneration, and refractive error. Additionally, new technologies such as next generation sequencing will require bioinformatics expertise to interpret the vast amount of information relevant for eye diseases.

描述（由申请人提供）：流行病学和生物统计学（EB）和基因组学与计算生物学（GCB）的研究生小组，与宾夕法尼亚大学（Penn）医学院的眼科系一起，提议开发眼科统计遗传学和生物信息学的博士前和博士后培训计划。宾大提倡一种学术环境，鼓励基础和临床研究，并将其视为对学员有吸引力的职业道路。该计划将吸引全国范围内的学员;毕业生将被安置在全国其他机构，从而产生高影响力的计划。培训计划将包括统计理论，统计遗传学，基因组学，计算生物学和眼科疾病的核心课程;广泛的独立阅读;参加期刊俱乐部和研究会议，重点是眼科统计遗传学和生物信息学;在EB，GCB和眼科系的研究研讨会，以及在翻译眼科研究方面的密切指导经验。博士前学员的课程将持续四到五年，由EB管理的生物统计学博士学位课程和GCB管理的基因组学和计算生物学博士学位课程提供结构;博士前学员将参加这些博士课程之一。为期两到三年的博士后课程专为在统计遗传学，生物信息学和/或计算生物学方面接受博士级培训的科学家而设计，他们寻求将其学科应用于眼科疾病的培训，以及寻求统计遗传学，生物信息学和/或计算生物学培训的眼科专业培训医生。 该方案旨在：1）培训严谨和独立的学术研究人员，能够使用统计学，统计遗传学，计算生物学和生物信息学的方法范围内进行眼科疾病的转化研究; 2）提供密集的，监督的研究经验与眼科统计遗传学和生物信息学的导师; 3）加强生物统计学、基因组学、计算生物学、生物信息学和眼科学之间的联系：4）鼓励眼科转化研究。当全面运作（第三年及以后的这个培训计划），四个奖学金名额将每年颁发。每年将向博士前受训人员颁发三项研究金，每年向一名博士后受训人员颁发一项研究金。拟议的计划的优势是：1）在EB和GCB成功的研究培训计划; 2）在EB，GCB和眼科，谁在广泛的学科提供专业知识的部门参与教师的可用性：3）参与教师所属的宾夕法尼亚大学的中心和研究所内进行的众多研究项目;以及四）各学院致力进行跨学科的合作研究和培训。 公共卫生相关性：在眼科统计遗传学和生物信息学方面进行严格研究所需的合格科学家在全国范围内严重短缺。随着基因组数据变得越来越复杂，随着新技术的帮助，问题变得越来越复杂，需要由统计遗传学家，生物信息学家和眼科医生组成的多学科团队来研究与眼睛相关的复杂特征。这样的团队将能够很好地确定糖尿病视网膜病变、青光眼、黄斑变性和屈光不正等复杂疾病的遗传变异和生物学途径。此外，新一代测序等新技术将需要生物信息学专业知识来解释与眼科疾病相关的大量信息。