Training in Ophthalmic Statistical Genetics and Bioinformatics

眼科统计遗传学和生物信息学培训

• 批准号: 8494622
• 负责人: Hongzhe Lee
• 金额: $ 16.33万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8494622
• 关键词: Bioinformatics; Genetic; Training

DESCRIPTION (provided by applicant): The graduate groups in Epidemiology and Biostatistics (EB) and Genomics & Computational Biology (GCB), in conjunction with the Department of Ophthalmology, all of the University of Pennsylvania (Penn) School of Medicine, propose to develop a pre- and post-doctoral training program in ophthalmic statistical genetics and bioinformatics. Penn promotes an academic environment in which basic and clinical research are encouraged and viewed as attractive career paths for trainees. This program will attract trainees nationwide; graduates will be placed in other institutions nationwide, resulting in a high impact program. The training program will consist of core courses in statistical theory, statistical genetics, genomics, computational biology, and ophthalmic disorders; extensive independent readings; participation in journal clubs and research conferences focusing on ophthalmic statistical genetics and bioinformatics; research seminars in the EB, GCB, and Department of Ophthalmology, and closely mentored experiences in translational ophthalmic research. The program for pre-doctoral trainees will be four to five years in duration, with structure provided by the PhD degree program in Biostatistics managed by the EB and the PhD degree program in Genomics & Computational Biology managed by GCB; pre-doctoral trainees will enroll in one of these PhD programs. The two- to three-year post-doctoral program is designed for scientists with PhD-level training in statistical genetics, bioinformatics, and/or computational biology who seek training in the application of their discipline to ophthalmic diseases and for physicians with specialty training in ophthalmology who seek training in statistical genetics, bioinformatics, and/or computational biology. The program is designed to: 1) train rigorous and independent academic investigators able to use the range of approaches available in statistics, statistical genetics, computational biology, and bioinformatics to conduct translational research in ophthalmic disorders; 2) provide intensive, supervised research experiences with mentors in ophthalmic statistical genetics and bioinformatics; 3) strengthen the links between biostatistics, genomics, computational biology, bioinformatics, and ophthalmology: 4) and encourage translational ophthalmic research. When fully operational (year three and beyond of this training program), four fellowship slots will be awarded annually. Three fellowships will be awarded annually to pre-doctoral trainees and one fellowship will be awarded annually to a post-doctoral trainee. Strengths of the proposed program are: 1) the successful research training programs in the EB and GCB; 2) the availability of participating faculty in the EB, GCB, and Department of Ophthalmology, who provide expertise in a wide range of disciplines: 3) numerous research projects conducted within centers and institutes at Penn with which participating faculty are affiliated; and 4) the faculties' commitment to collaborative and multidisciplinary research and training.

描述（由申请人提供）：流行病学与生物统计学（EB）和基因组学与计算生物学（GCB）的研究生小组，与宾夕法尼亚大学医学院眼科学系合作，提议在眼科统计遗传学和生物信息学方面开展前和博士后培训计划。宾大提倡鼓励基础和临床研究的学术环境，并将其视为有吸引力的职业道路。该项目将在全国范围内吸引学员；毕业生将被安置在全国其他机构，从而形成一个高影响力的项目。培训计划将包括统计理论、统计遗传学、基因组学、计算生物学和眼科疾病等核心课程；广泛的独立阅读；参加以眼科统计遗传学和生物信息学为重点的期刊俱乐部和研究会议；参加了EB、GCB和眼科的研究研讨会，并密切指导了眼科转化研究的经验。博士预科培养项目学制4 - 5年，由EB管理的生物统计学博士学位项目和GCB管理的基因组学与计算生物学博士学位项目提供结构；博士预科生将入读其中一个博士课程。这个为期两到三年的博士后项目是为在统计遗传学、生物信息学和/或计算生物学方面受过博士水平训练的科学家设计的，他们寻求将自己的学科应用于眼科疾病方面的培训，也为受过眼科专业培训的医生设计的，他们寻求在统计遗传学、生物信息学和/或计算生物学方面的培训。该计划旨在：1)培养严谨和独立的学术研究者，能够使用统计学，统计遗传学，计算生物学和生物信息学中可用的方法进行眼科疾病的转化研究；2)与导师在眼科统计遗传学和生物信息学方面提供密集的、有监督的研究经验；3)加强生物统计学、基因组学、计算生物学、生物信息学和眼科学之间的联系；4)鼓励眼科学的转化研究。当全面运作时（培训计划的第三年及以后），每年将颁发四个奖学金名额。每年将向博士预科生颁发3个奖学金，向博士后实习生颁发1个奖学金。该计划的优势在于：1)EB和GCB中成功的研究培训计划；2) EB、GCB和眼科的参与教师的可用性，他们在广泛的学科领域提供专业知识；3)参与教师所属的宾夕法尼亚大学中心和研究所开展了大量的研究项目；4)学院致力于合作和多学科研究与培训。