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A Ribozyme Rescue Strategy for Dry Age-Related Macular Degeneration

A Ribozyme Rescue Strategy for Dry Age-Related Macular Degeneration
干性年龄相关性黄斑变性的核酶救援策略
批准号：
7919436
负责人：
JOHN M. SULLIVAN
金额：
$0.0万
依托单位：
VA WESTERN NEW YORK HEALTHCARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-10-01 至 2013-09-30
来源：
https://reporter.nih.gov/project-details/7919436
关键词：
AddressAdolescentAffectAgeAge related macular degenerationAgingAmericanApoptosisAtrophicBiochemicalBiomassBlindnessCarbohydratesCatalytic RNACell DeathCellsCessation of lifeChemicalsCircadian RhythmsClinicClinical TrialsDepositionDigestionDiseaseDrusenElderlyElectroretinographyElementsEngineeringEthanolaminesFlecksFundusGeneticHealthHealthcareHigh Pressure Liquid ChromatographyHistologyHumanIndividualInferiorKnock-outLeadLifeLightLightingLipidsLipofuscinMacular degenerationMeasuresMediatingMembraneMessenger RNAMetabolicMinorMolecularMolecular TargetMusNatural regenerationNeurogliaNonexudative age-related macular degenerationOpsinOutcomeOxidative StressPerformancePhagocytosisPhagolysosomePhasePhotoreceptorsPhototoxicityPigmentsPrevalenceProductionProteinsRNA InterferenceReactionRecombinant adeno-associated virus (rAAV)RetinalRetinal ConeRetinal DegenerationRetinal PigmentsRetinaldehydeRetinoidsRetinol dehydrogenaseRhodopsinRod Outer SegmentsSaltsSiteSocietiesSpecificityStructureStructure of retinal pigment epitheliumSystemTestingTherapeuticTimeToxic effectVertebrate PhotoreceptorsVeteransVisible RadiationVisionVisualVitaminsadeno-associated viral vectorage relatedbasedesigndimerdisabilitygene therapyhammerhead ribozymein vivomaculamouse modelnormal agingnovelnovel strategiespre-clinicalpublic health relevanceresearch studyretinal rodssafety studysingle moleculesmall hairpin RNAsmall moleculesuccesstoolvisual cycle

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