A Ribozyme Rescue Strategy for Dry Age-Related Macular Degeneration

干性年龄相关性黄斑变性的核酶救援策略

• 批准号: 7919436
• 负责人: JOHN M. SULLIVAN
• 金额: --
• 依托单位: VA WESTERN NEW YORK HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7919436
• 关键词: Address; Adolescent; Affect; Age; Age related macular degeneration; Aging; American; Apoptosis; Atrophic; Biochemical; Biomass; Blindness; Carbohydrates; Catalytic RNA; Cell Death; Cells; Cessation of life; Chemicals; Circadian Rhythms; Clinic; Clinical Trials; Deposition; Digestion; Disease; Drusen; Elderly; Electroretinography; Elements; Engineering; Ethanolamines; Flecks; Fundus; Genetic; Health; Healthcare; High Pressure Liquid Chromatography; Histology; Human; Individual; Inferior; Knock-out; Lead; Life; Light; Lighting; Lipids; Lipofuscin; Macular degeneration; Measures; Mediating; Membrane; Messenger RNA; Metabolic; Minor; Molecular; Molecular Target; Mus; Natural regeneration; Neuroglia; Nonexudative age-related macular degeneration; Opsin; Outcome; Oxidative Stress; Performance; Phagocytosis; Phagolysosome; Phase; Photoreceptors; Phototoxicity; Pigments; Prevalence; Production; Proteins; RNA Interference; Reaction; Recombinant adeno-associated virus (rAAV); Retinal; Retinal Cone; Retinal Degeneration; Retinal Pigments; Retinaldehyde; Retinoids; Retinol dehydrogenase; Rhodopsin; Rod Outer Segments; Salts; Site; Societies; Specificity; Structure; Structure of retinal pigment epithelium; System; Testing; Therapeutic; Time; Toxic effect; Vertebrate Photoreceptors; Veterans; Visible Radiation; Vision; Visual; Vitamins; adeno-associated viral vector; age related; base; design; dimer; disability; gene therapy; hammerhead ribozyme; in vivo; macula; mouse model; normal aging; novel; novel strategies; pre-clinical; public health relevance; research study; retinal rods; safety study; single molecule; small hairpin RNA; small molecule; success; tool; visual cycle