Administrative Core

行政核心

基本信息

  • 批准号:
    8675859
  • 负责人:
  • 金额:
    $ 17.21万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
  • 资助国家:
    美国
  • 起止时间:
    至 2016-04-30
  • 项目状态:
    已结题

项目摘要

The proposed RESAC Center, entitled Respiratory Effects of Silver and Carbon Nanomaterials, builds on the long-term collaborative relationship between UMDNJ/Rutgers and Imperial College London. This relationship started in 2000-2001 when Dr. Zhang was spending his sabbatical leave at Imperial College. Since then Drs. Zhang and Chung, along with other researchers at UMDNJ and Imperial College, have collaborated on the worid's first study of acute respiratory effects of real-worid exposure to diesel exhaust particles in persons with asthma. This study generated a seminal paper published in New England Journal of Medicine. Drs. Zhang, Chung, and Tetley have continued to collaborate and developed research proposals to further investigate pathophysiological mechanisms underiying cardio-respiratory effects of exposure to diesel exhaust particles and to consumer products containing ENMs, respecfively. (Funding decisions are pending.) The UMDNJ/Rutgers investigators who are part of the RESAC Center proposal are all members of the NlEHS-funded Center for Environmental Exposure and Diseases (CEED) at the Environmental and Occupafional Health Sciences Institute (EOHSI) in New Jersey. The CEED researchers probe scientific questions related to the multidimensional interface between environmental/occupational exposure and human health. This is reflected by the wide range of multidisciplinary expertise (e.g., exposure and risk assessment, PBPK modeling, toxicology, immunology, biostatistics) possessed by the CEED members participafing in the proposed RESAC Center. The UK collaborators provide complimentary expertise (e.g., nano-toxicology, lung and cell biology, pulmonary medicine, nanomaterial synthesis and characterization), enhancing the capability of the RESAC Center to address critical issues called for by the current U19 RFA. The RESAC Center's organizational chart is shown in Figure ACI. The RESAC Center consists of an administrative core, a scientific core, and three research projects. Additionally, the Center has an Integration Committee and a Scientific Advisory Committee. This organizafional structure is designed to encourage, maximize, and facilitate interactions both within and between the research projects, among researchers, and with other centers participating in the NIEHS Consortium established through this RFA. The organizational structure is designed to address, in a highly integrated and synergistic way, the overarching theme of the RESAC Center: the interaction between ENMs and the components of the lung lining fluid. Our Center's approaches involves the use of (1) two model ENMs, nano silver and carbon nanotube, with a large contrast in their physiochemical properties (Scientific Core), (2) a suite of in vitro experiments determining ENM effects and interacfions with the lung lining fluid at the cellular and molecular level (Project 1), (3) a set of in vivo studies to study ENM fate in the lung and physiological effects and underiying mechanisms (project 2), and (4) computational models that can specifically accommodate the unique physicochemical (and consequently toxicological) characteristics of ENMs in the characterization of risk (Project 3).
拟议的RESAC中心,题为呼吸效应的银和碳纳米材料,建立在UMDNJ/罗格斯大学和帝国理工学院伦敦之间的长期合作关系。这种关系始于2000-2001年,当时张博士正在帝国理工学院休假。 从那时起,张博士和钟博士与UMDNJ和帝国理工学院的其他研究人员沿着合作,进行了世界上第一项关于哮喘患者接触柴油废气颗粒对急性呼吸系统影响的研究。这项研究产生了一篇发表在《新英格兰医学杂志》上的开创性论文。 药Zhang博士、Chung博士和Tetley博士继续合作并制定研究方案,以进一步研究暴露于柴油机尾气颗粒和含有ENM的消费品对心肺影响的病理生理机制。(供资决定待定。 作为RESAC中心提案一部分的UMDNJ/Rutgers研究人员都是新泽西环境与职业健康科学研究所(EOHSI)NlEHS资助的环境暴露与疾病中心(CEED)的成员。CEED的研究人员探讨了与环境/职业暴露和人类健康之间的多维界面相关的科学问题。 健康这反映在广泛的多学科专业知识(例如,暴露和风险评估,PBPK建模,毒理学,免疫学,生物统计学), 中心的建议。英国合作者提供免费的专业知识(例如,纳米毒理学、肺和细胞生物学、肺医学、纳米材料合成和表征),增强RESAC中心解决当前U19 RFA所要求的关键问题的能力。RESAC中心 组织结构图见图ACI。 RESAC中心由一个行政核心、一个科学核心和三个研究项目组成。此外,该中心还设有一个整合委员会和一个科学咨询委员会。该组织结构旨在鼓励,最大限度地提高和促进研究项目内部和之间的互动,研究人员之间,以及与通过该RFA建立的NIEHS联盟的其他中心的互动。组织结构旨在以高度集成和协同的方式解决RESAC中心的首要主题:ENM与肺衬里液成分之间的相互作用。我们中心的方法包括使用(1)两种模型ENM,纳米银和碳纳米管,它们的物理化学性质有很大的对比(2)一系列体外实验,确定ENM效应以及在细胞和分子水平上与肺衬里液的相互作用(项目1),(3)一组研究ENM在肺中的命运和生理效应及其机制的体内研究(项目2),和(4)计算模型,可以特别适应独特的物理化学在风险定性中确定化学物质的特性(以及随后的毒理学特性)(项目3)。

项目成果

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JUNFENG ZHANG其他文献

JUNFENG ZHANG的其他文献

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{{ truncateString('JUNFENG ZHANG', 18)}}的其他基金

Molecular Mechanisms for Resolving Air Pollution Induced Pulmonary Inflammation: Potential Differences by Asthma and Sex (RAPIDAS)
解决空气污染引起的肺部炎症的分子机制:哮喘和性别的潜在差异(RAPIDAS)
  • 批准号:
    10718525
  • 财政年份:
    2023
  • 资助金额:
    $ 17.21万
  • 项目类别:
Opportunities and Innovation Fund Component
机会和创新基金部分
  • 批准号:
    10744470
  • 财政年份:
    2016
  • 资助金额:
    $ 17.21万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    8068441
  • 财政年份:
    2010
  • 资助金额:
    $ 17.21万
  • 项目类别:
Responses to Drastic Changes in Air Pollution: Reversibility and Susceptibility
对空气污染急剧变化的反应:可逆性和敏感性
  • 批准号:
    7555954
  • 财政年份:
    2008
  • 资助金额:
    $ 17.21万
  • 项目类别:
Responses to Drastic Changes in Air Pollution: Reversibility and Susceptibility
对空气污染急剧变化的反应:可逆性和敏感性
  • 批准号:
    7387939
  • 财政年份:
    2008
  • 资助金额:
    $ 17.21万
  • 项目类别:
Responses to Drastic Changes in Air Pollution: Reversibility and Susceptibility
对空气污染急剧变化的反应:可逆性和敏感性
  • 批准号:
    8249183
  • 财政年份:
    2008
  • 资助金额:
    $ 17.21万
  • 项目类别:
ISEA 2004 Conference
ISEA 2004 会议
  • 批准号:
    6837298
  • 财政年份:
    2004
  • 资助金额:
    $ 17.21万
  • 项目类别:
Validation of PAH Biomarkers for Quantifying Cancer Risk
验证用于量化癌症风险的 PAH 生物标志物
  • 批准号:
    6654411
  • 财政年份:
    2001
  • 资助金额:
    $ 17.21万
  • 项目类别:
Validation of PAH Biomarkers for Quantifying Cancer Risk
验证用于量化癌症风险的 PAH 生物标志物
  • 批准号:
    6522503
  • 财政年份:
    2001
  • 资助金额:
    $ 17.21万
  • 项目类别:
Validation of PAH Biomarkers for Quantifying Cancer Risk
验证用于量化癌症风险的 PAH 生物标志物
  • 批准号:
    6448340
  • 财政年份:
    2001
  • 资助金额:
    $ 17.21万
  • 项目类别:

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