Validation of PAH Biomarkers for Quantifying Cancer Risk

验证用于量化癌症风险的 PAH 生物标志物

基本信息

  • 批准号:
    6448340
  • 负责人:
  • 金额:
    $ 21.89万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-09-30 至 2004-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Biological monitoring is particularly useful for assessing exposure to pollutants, such as polycyclic aromatic hydrocarbons (PAHs), that are present in multiple environmental media. Although a number of PAH biomarkers have been developed, epidemiological studies relating cancer mortality to average biomarker concentrations are lacking; and the current risk assessment frame is based on air concentrations of benzo[a]pyrene (BaP). The goal of the proposed study is to fill in several important gaps that have hampered the application of PAH biomarkers in quantifying cancer risk. Two urinary markers, 1-hydroxypyrene and 9-hydroxy-benzo[a]pyrene, will be specifically validated for this purpose through achieving the following specific aims. Aim 1 is to establish a quantitative relationship between urinary concentrations and BaP exposure which will be measured as 24-h average personal air concentration and 24-h dietary intake. Aim 2 is to examine whether there is a significant day-to-day variation in urinary marker concentrations in study subjects having stable daily PAH exposures. This is important because for a biomarker to be useful for estimating cancer risk, this marker should be able to predict people's average (steady) exposure. Aim 3 is to examine whether a first morning urine sample can efficiently represent daily exposure or a 24-hour composite urine sample is required. This is of practical importance because 24-h urine samples are considerably harder to get in free-living populations. Aim 4 is to examine relationships between urinary markers and other PAH metrics, because other metrics of PAH mixture may prove to be a better index for future risk assessment. The study will be carried out in 100 non-smoking adults with a wide range of exposure to airborne BaP, including both occupationally and non-occupationally exposed individuals. This is necessary to evaluate the effectiveness of these biomarkers in a broader application, because high PAH exposures can occur not only in many occupational settings but also in the daily lives of other people, including non-smokers. The study will consist of two sets of repeated measurements for each subject. Each set of the measurement will include: 24-h personal breathing-zone concentrations of gas-phase and particle-phase PAHs; 24-h dietary PAH intakes; biomarker concentrations in first morning urine and in 24-h composite urine. All these measurements will be made within the same 24-h period. Two repeated measurements will be separated by at least three months for each subject to maximize the representativeness of daily exposure. Air samples and food samples will be analyzed for at least 16 common PAHs including pyrene and BaP using the established HPLC/fluorescence methods. The spot nature of urinary concentrations will be corrected with creatinine. Statistical methods to be used will include descriptive analyses, scatter plots, correlation analyses, paired comparisons, and linear mixed models. In the mixed models, age, sex, height, weight, and body mass index will be adjusted for.
描述(由申请人提供): 生物监测对于评估接触以下物质特别有用: 污染物,如多环芳烃(PAH),存在 在多种环境介质中。尽管许多PAH生物标志物已经被 发达的流行病学研究,癌症死亡率与平均 缺乏生物标志物浓度;目前的风险评估框架是 苯并[a]芘(BaP)的空气浓度。建议的目标 这项研究的目的是填补阻碍应用的几个重要空白 PAH生物标志物在量化癌症风险中的作用。两项尿指标, 1-羟基芘和9-羟基-苯并[a]芘,将进行专门验证 为此目的,通过实现以下具体目标。目标1: 建立尿中苯并(a)芘浓度与尿中苯并(a)芘浓度的定量关系 暴露量将被测量为24小时平均个人空气浓度, 24小时饮食摄入量。目标2是检查是否存在显著的 研究受试者中尿标记物浓度的日间变化 稳定的每日PAH暴露。这一点很重要,因为生物标志物 对于估计癌症风险有用,这个标记应该能够预测 人们的平均(稳定)暴露。目的3是检查是否第一次 晨尿样本可以有效地代表每日暴露或24小时暴露。 需要混合尿样。这具有实际意义,因为 在自由生活的人群中,24小时尿液样本更难获得。 目的4是检查尿标志物与其他PAH之间的关系 指标,因为PAH混合物的其他指标可能被证明是更好的指标 未来的风险评估。这项研究将在100个非吸烟 广泛暴露于空气中苯并(a)芘的成年人,包括 职业性和非职业性接触者。这是必要 为了评价这些生物标志物在更广泛应用中的有效性, 因为高PAH暴露不仅发生在许多职业环境中, 而且在其他人的日常生活中,包括不吸烟者。研究 将由每名受试者的两组重复测量组成。每组 的测量将包括:24小时个人呼吸区浓度 气相和颗粒相多环芳烃; 24小时膳食多环芳烃摄入量;生物标志物 第一次晨尿和24小时复合尿中的浓度。所有这些 将在同一24小时内进行测量。两个重复 每例受试者的测量将间隔至少三个月, 最大限度地提高日常曝光的代表性。空气样本和食物 将对样品进行至少16种常见多环芳烃的分析,包括芘和苯并[a]芘 使用已建立的HPLC/荧光方法。尿的斑点性质 将用肌酐校正浓度。统计学方法 使用的方法包括描述性分析、散点图、相关性分析 配对比较和线性混合模型。在混合模型中,年龄,性别, 身高、体重和体重指数将进行调整。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
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专利数量(0)

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JUNFENG ZHANG其他文献

JUNFENG ZHANG的其他文献

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{{ truncateString('JUNFENG ZHANG', 18)}}的其他基金

Molecular Mechanisms for Resolving Air Pollution Induced Pulmonary Inflammation: Potential Differences by Asthma and Sex (RAPIDAS)
解决空气污染引起的肺部炎症的分子机制:哮喘和性别的潜在差异(RAPIDAS)
  • 批准号:
    10718525
  • 财政年份:
    2023
  • 资助金额:
    $ 21.89万
  • 项目类别:
Opportunities and Innovation Fund Component
机会和创新基金部分
  • 批准号:
    10744470
  • 财政年份:
    2016
  • 资助金额:
    $ 21.89万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    8068441
  • 财政年份:
    2010
  • 资助金额:
    $ 21.89万
  • 项目类别:
Responses to Drastic Changes in Air Pollution: Reversibility and Susceptibility
对空气污染急剧变化的反应:可逆性和敏感性
  • 批准号:
    7555954
  • 财政年份:
    2008
  • 资助金额:
    $ 21.89万
  • 项目类别:
Responses to Drastic Changes in Air Pollution: Reversibility and Susceptibility
对空气污染急剧变化的反应:可逆性和敏感性
  • 批准号:
    7387939
  • 财政年份:
    2008
  • 资助金额:
    $ 21.89万
  • 项目类别:
Responses to Drastic Changes in Air Pollution: Reversibility and Susceptibility
对空气污染急剧变化的反应:可逆性和敏感性
  • 批准号:
    8249183
  • 财政年份:
    2008
  • 资助金额:
    $ 21.89万
  • 项目类别:
ISEA 2004 Conference
ISEA 2004 会议
  • 批准号:
    6837298
  • 财政年份:
    2004
  • 资助金额:
    $ 21.89万
  • 项目类别:
Validation of PAH Biomarkers for Quantifying Cancer Risk
验证用于量化癌症风险的 PAH 生物标志物
  • 批准号:
    6654411
  • 财政年份:
    2001
  • 资助金额:
    $ 21.89万
  • 项目类别:
Validation of PAH Biomarkers for Quantifying Cancer Risk
验证用于量化癌症风险的 PAH 生物标志物
  • 批准号:
    6522503
  • 财政年份:
    2001
  • 资助金额:
    $ 21.89万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    8675859
  • 财政年份:
  • 资助金额:
    $ 21.89万
  • 项目类别:

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