Validation of PAH Biomarkers for Quantifying Cancer Risk
验证用于量化癌症风险的 PAH 生物标志物
基本信息
- 批准号:6522503
- 负责人:
- 金额:$ 21.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-09-30 至 2004-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant):
Biological monitoring is particularly useful for assessing exposure to
pollutants, such as polycyclic aromatic hydrocarbons (PAHs), that are present
in multiple environmental media. Although a number of PAH biomarkers have been
developed, epidemiological studies relating cancer mortality to average
biomarker concentrations are lacking; and the current risk assessment frame is
based on air concentrations of benzo[a]pyrene (BaP). The goal of the proposed
study is to fill in several important gaps that have hampered the application
of PAH biomarkers in quantifying cancer risk. Two urinary markers,
1-hydroxypyrene and 9-hydroxy-benzo[a]pyrene, will be specifically validated
for this purpose through achieving the following specific aims. Aim 1 is to
establish a quantitative relationship between urinary concentrations and BaP
exposure which will be measured as 24-h average personal air concentration and
24-h dietary intake. Aim 2 is to examine whether there is a significant
day-to-day variation in urinary marker concentrations in study subjects having
stable daily PAH exposures. This is important because for a biomarker to be
useful for estimating cancer risk, this marker should be able to predict
people's average (steady) exposure. Aim 3 is to examine whether a first
morning urine sample can efficiently represent daily exposure or a 24-hour
composite urine sample is required. This is of practical importance because
24-h urine samples are considerably harder to get in free-living populations.
Aim 4 is to examine relationships between urinary markers and other PAH
metrics, because other metrics of PAH mixture may prove to be a better index
for future risk assessment. The study will be carried out in 100 non-smoking
adults with a wide range of exposure to airborne BaP, including both
occupationally and non-occupationally exposed individuals. This is necessary
to evaluate the effectiveness of these biomarkers in a broader application,
because high PAH exposures can occur not only in many occupational settings
but also in the daily lives of other people, including non-smokers. The study
will consist of two sets of repeated measurements for each subject. Each set
of the measurement will include: 24-h personal breathing-zone concentrations
of gas-phase and particle-phase PAHs; 24-h dietary PAH intakes; biomarker
concentrations in first morning urine and in 24-h composite urine. All these
measurements will be made within the same 24-h period. Two repeated
measurements will be separated by at least three months for each subject to
maximize the representativeness of daily exposure. Air samples and food
samples will be analyzed for at least 16 common PAHs including pyrene and BaP
using the established HPLC/fluorescence methods. The spot nature of urinary
concentrations will be corrected with creatinine. Statistical methods to be
used will include descriptive analyses, scatter plots, correlation analyses,
paired comparisons, and linear mixed models. In the mixed models, age, sex,
height, weight, and body mass index will be adjusted for.
描述(由申请人提供):
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JUNFENG ZHANG其他文献
JUNFENG ZHANG的其他文献
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Responses to Drastic Changes in Air Pollution: Reversibility and Susceptibility
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Responses to Drastic Changes in Air Pollution: Reversibility and Susceptibility
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Validation of PAH Biomarkers for Quantifying Cancer Risk
验证用于量化癌症风险的 PAH 生物标志物
- 批准号:
6654411 - 财政年份:2001
- 资助金额:
$ 21.05万 - 项目类别:
Validation of PAH Biomarkers for Quantifying Cancer Risk
验证用于量化癌症风险的 PAH 生物标志物
- 批准号:
6448340 - 财政年份:2001
- 资助金额:
$ 21.05万 - 项目类别:
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