Validation of PAH Biomarkers for Quantifying Cancer Risk

验证用于量化癌症风险的 PAH 生物标志物

基本信息

  • 批准号:
    6522503
  • 负责人:
  • 金额:
    $ 21.05万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-09-30 至 2004-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Biological monitoring is particularly useful for assessing exposure to pollutants, such as polycyclic aromatic hydrocarbons (PAHs), that are present in multiple environmental media. Although a number of PAH biomarkers have been developed, epidemiological studies relating cancer mortality to average biomarker concentrations are lacking; and the current risk assessment frame is based on air concentrations of benzo[a]pyrene (BaP). The goal of the proposed study is to fill in several important gaps that have hampered the application of PAH biomarkers in quantifying cancer risk. Two urinary markers, 1-hydroxypyrene and 9-hydroxy-benzo[a]pyrene, will be specifically validated for this purpose through achieving the following specific aims. Aim 1 is to establish a quantitative relationship between urinary concentrations and BaP exposure which will be measured as 24-h average personal air concentration and 24-h dietary intake. Aim 2 is to examine whether there is a significant day-to-day variation in urinary marker concentrations in study subjects having stable daily PAH exposures. This is important because for a biomarker to be useful for estimating cancer risk, this marker should be able to predict people's average (steady) exposure. Aim 3 is to examine whether a first morning urine sample can efficiently represent daily exposure or a 24-hour composite urine sample is required. This is of practical importance because 24-h urine samples are considerably harder to get in free-living populations. Aim 4 is to examine relationships between urinary markers and other PAH metrics, because other metrics of PAH mixture may prove to be a better index for future risk assessment. The study will be carried out in 100 non-smoking adults with a wide range of exposure to airborne BaP, including both occupationally and non-occupationally exposed individuals. This is necessary to evaluate the effectiveness of these biomarkers in a broader application, because high PAH exposures can occur not only in many occupational settings but also in the daily lives of other people, including non-smokers. The study will consist of two sets of repeated measurements for each subject. Each set of the measurement will include: 24-h personal breathing-zone concentrations of gas-phase and particle-phase PAHs; 24-h dietary PAH intakes; biomarker concentrations in first morning urine and in 24-h composite urine. All these measurements will be made within the same 24-h period. Two repeated measurements will be separated by at least three months for each subject to maximize the representativeness of daily exposure. Air samples and food samples will be analyzed for at least 16 common PAHs including pyrene and BaP using the established HPLC/fluorescence methods. The spot nature of urinary concentrations will be corrected with creatinine. Statistical methods to be used will include descriptive analyses, scatter plots, correlation analyses, paired comparisons, and linear mixed models. In the mixed models, age, sex, height, weight, and body mass index will be adjusted for.
描述(由申请人提供):

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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JUNFENG ZHANG其他文献

JUNFENG ZHANG的其他文献

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{{ truncateString('JUNFENG ZHANG', 18)}}的其他基金

Molecular Mechanisms for Resolving Air Pollution Induced Pulmonary Inflammation: Potential Differences by Asthma and Sex (RAPIDAS)
解决空气污染引起的肺部炎症的分子机制:哮喘和性别的潜在差异(RAPIDAS)
  • 批准号:
    10718525
  • 财政年份:
    2023
  • 资助金额:
    $ 21.05万
  • 项目类别:
Opportunities and Innovation Fund Component
机会和创新基金部分
  • 批准号:
    10744470
  • 财政年份:
    2016
  • 资助金额:
    $ 21.05万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    8068441
  • 财政年份:
    2010
  • 资助金额:
    $ 21.05万
  • 项目类别:
Responses to Drastic Changes in Air Pollution: Reversibility and Susceptibility
对空气污染急剧变化的反应:可逆性和敏感性
  • 批准号:
    7555954
  • 财政年份:
    2008
  • 资助金额:
    $ 21.05万
  • 项目类别:
Responses to Drastic Changes in Air Pollution: Reversibility and Susceptibility
对空气污染急剧变化的反应:可逆性和敏感性
  • 批准号:
    7387939
  • 财政年份:
    2008
  • 资助金额:
    $ 21.05万
  • 项目类别:
Responses to Drastic Changes in Air Pollution: Reversibility and Susceptibility
对空气污染急剧变化的反应:可逆性和敏感性
  • 批准号:
    8249183
  • 财政年份:
    2008
  • 资助金额:
    $ 21.05万
  • 项目类别:
ISEA 2004 Conference
ISEA 2004 会议
  • 批准号:
    6837298
  • 财政年份:
    2004
  • 资助金额:
    $ 21.05万
  • 项目类别:
Validation of PAH Biomarkers for Quantifying Cancer Risk
验证用于量化癌症风险的 PAH 生物标志物
  • 批准号:
    6654411
  • 财政年份:
    2001
  • 资助金额:
    $ 21.05万
  • 项目类别:
Validation of PAH Biomarkers for Quantifying Cancer Risk
验证用于量化癌症风险的 PAH 生物标志物
  • 批准号:
    6448340
  • 财政年份:
    2001
  • 资助金额:
    $ 21.05万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    8675859
  • 财政年份:
  • 资助金额:
    $ 21.05万
  • 项目类别:

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