Preclinical Evaluation Of Neutralizing Antibodies Elicited by HIV-1 Immunogens
Preclinical Evaluation Of Neutralizing Antibodies Elicited by HIV-1 Immunogens
批准号:
8148416
负责人:
John Mascola
金额:
$44.4万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
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英文摘要
The present studies examine the breadth and magnitude of neutralizing antibody responses in small animals and rhesus monkeys after various immunization regimens. Using a standardized multi-tier panel of reference Env pseudoviruses for neutralizing antibody assessment, we show that both protein immunization, and DNA prime, rAd boost immunization, can generate high antibody titers. Ongoing studies are evaluating novel immunogens based on structure-based information from studies of the HIV-1 envelope glycoprotein.
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Next Generation Development of Broadly Neutralizing HIV Antibodies for Prevention
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批准号:9925140
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项目类别:
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资助金额:$669.92万
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财政年份:2018
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负责人:John Mascola
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依托单位:
HIV/AIDS Vaccine and Antibody Development
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批准号:10274167
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项目类别:
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资助金额:$178.95万
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财政年份:--
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负责人:John Mascola
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依托单位:
Pre-clinical Vaccine Development for Respiratory Viruses
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批准号:10274170
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项目类别:
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资助金额:$274.8万
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财政年份:--
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负责人:John Mascola
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依托单位:
Pre-clinical Vaccine and Antibody Development for Coronavirus Disease 2019 (COVID-19)
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批准号:10497761
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项目类别:
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资助金额:$39.31万
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财政年份:--
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负责人:John Mascola
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依托单位:
Non-human Primate Immunogenicity Studies of HIV-1 immunogens
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批准号:8745607
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项目类别:
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资助金额:$33.08万
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财政年份:--
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负责人:John Mascola
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依托单位:
Isolation and Deep Sequencing of Monoclonal Antiobodies Against HIV
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批准号:8946599
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项目类别:
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资助金额:$44.08万
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财政年份:--
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负责人:John Mascola
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依托单位:
Measurement of HIV Neutralization Using Quantitative Assays
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批准号:8946567
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项目类别:
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资助金额:$31.87万
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财政年份:--
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负责人:John Mascola
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依托单位:
Measurement of HIV Neutralization Using Quantitative Assays
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批准号:9161744
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项目类别:
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资助金额:$31.87万
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财政年份:--
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负责人:John Mascola
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依托单位:
Modifications to improve HIV neutralizing antibodies
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批准号:8946603
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项目类别:
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资助金额:$180.0万
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财政年份:--
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负责人:John Mascola
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依托单位:
Non Human Primate Models of SIV and HIV Immune Protection
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批准号:8336367
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项目类别:
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资助金额:$33.08万
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财政年份:--
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负责人:John Mascola
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依托单位:
Measurement of HIV Neutralization Using Quantitative Assays
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批准号:8336368
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项目类别:
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资助金额:$22.05万
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财政年份:--
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负责人:John Mascola
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依托单位:
Measurement of HIV Neutralization Using Quantitative Assays
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批准号:8556086
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项目类别:
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资助金额:$22.05万
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财政年份:--
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负责人:John Mascola
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依托单位:
Quantitative Immunological Assays to Assess HIV Antibodies and Vaccines
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批准号:10021347
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项目类别:
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资助金额:$55.26万
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财政年份:--
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负责人:John Mascola
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依托单位:
Isolation of Monoclonal Antiobodies Against HIV
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批准号:7964877
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项目类别:
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资助金额:$21.17万
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财政年份:--
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负责人:John Mascola
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依托单位:
Non Human Primate Models of SIV and HIV Immune Protection
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批准号:8148413
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项目类别:
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资助金额:$33.3万
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财政年份:--
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负责人:John Mascola
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依托单位:
Isolation of Monoclonal Antiobodies Against HIV
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批准号:8148443
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项目类别:
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资助金额:$44.4万
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财政年份:--
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负责人:John Mascola
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依托单位:
HIV/AIDS Vaccine Development
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批准号:8946564
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项目类别:
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资助金额:$647.9万
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财政年份:--
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负责人:John Mascola
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依托单位:
Pre-clinical Vaccine Development for Emerging and Re-emerging Infectious Diseases
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批准号:10274169
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项目类别:
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资助金额:$412.29万
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财政年份:--
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负责人:John Mascola
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依托单位:
HIV Neutralizing Antibodies: Isolation, characterization, and interaction with viral variants
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批准号:10497743
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项目类别:
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资助金额:$86.74万
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财政年份:--
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负责人:John Mascola
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依托单位:
Pre-clinical Vaccine Development for Respiratory Viruses
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批准号:10497783
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项目类别:
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资助金额:$254.36万
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财政年份:--
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负责人:John Mascola
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依托单位:
国内基金
海外基金
Neo-antigens暴露对肾移植术后体液性排斥反应的影响及其机制研究
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批准号:2022J011295
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项目类别:省市级项目
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资助金额:10.0万元
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批准年份:2022
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负责人:王亚伟
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依托单位:
结核分枝杆菌持续感染期抗原(latency antigens)的重组BCG疫苗研究
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批准号:30801055
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项目类别:青年科学基金项目
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资助金额:19.0万元
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批准年份:2008
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负责人:王丽梅
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依托单位: