Monomers and nanogel to improve adhesive resin structural integrity/durability

描述（由申请人提供）：由于美国每年进行的超过100，000万次牙科修复治疗中的大多数涉及树脂粘结复合材料的放置，并且认识到牙医的大部分时间都用于修改和更换这些材料，因此显然需要具有改进临床性能的材料。复合材料修复剂不仅比牙科汞合金具有美学优势，而且还提供了一种将修复体与牙本质和牙釉质粘合的方法。然而，由于湿结合技术带来的挑战，在该关键界面聚合之前、期间或之后的延长间隔内水诱导相分离的可能性，目前不能可靠地获得强的完整边缘。该提案描述了新的水相容性单体的开发计划，与HEMA相比，该单体具有改善反应性、避免相分离以及生产化学和机械上健全的聚合物网络的潜力。已经开发了一种高度通用的技术，用于制备纳米级（10 - 30 nm）的聚合物颗粒，控制支化，化学和反应位点的位置。这些反应性纳米凝胶可以容易地以高浓度分散在第二单体中，然后渗透并随后与预聚物添加剂共聚。该项目围绕三个具体目标：1）开发水相容性单体作为HEMA的替代品或补充，以更好地保持整个粘合剂树脂的均匀性和高交联密度; 2）纳米凝胶改性粘合剂的积极初步结果将扩展到水中-可分散的反应性纳米凝胶，其提供增强的结构均匀性和稳定性，同时引入不能作为游离单体分散在水中的组分;以及3）与粘合剂层和界面的成像相结合的微/纳米机械性能表征将共同用作分析工具，以更好地理解与现有材料以及本文提出的先进粘合剂中的牙本质和粘合剂树脂之间的相互作用相关的结构和性能。我们期望将粘合剂树脂相的稳定性与胶原蛋白保护策略相关联，所述胶原蛋白保护策略包括基于非迁移性纳米凝胶平台的胶原蛋白交联、抗菌活性和MMP抑制特性。该申请将提供对现有粘合剂系统的优点和缺点的更好理解，同时开发新材料，以解决粘合牙科牙体充填的粘合剂和混合层内的结构稳定性和耐久性的重大当前问题。

DESCRIPTION (provided by applicant): With a majority of the more than 100,000 million dental restorative treatments performed in the US each year involving the placement of resin-bonded composite materials, and the acknowledgement that a large portion of a dentist's time is consumed with revising and replacing these restorations, there is a clear need for materials with improved clinical performance. Composite restoratives not only hold an esthetic advantage over dental amalgams, but they offer a means to adhesively bond the restoration to dentin and enamel. However, due to challenges imposed by wet bonding techniques, the potential for water-induced phase separation prior to, during or over extended intervals following polymerization of this critical interface, a strong, intact margin cannot currently be reliably obtained. This proposal describes the development plan for new water compatible monomers that compared with HEMA, offer the potential for improved reactivity, avoidance of phase separation and the production of chemically and mechanically sound polymer networks. A highly versatile technique has been developed for preparing nano-scale (10 - 30 nm) polymeric particles with control over branching, chemistry and reactive site placement. These reactive nanogels can be dispersed readily at high concentrations in secondary monomers, which then infiltrate and subsequently copolymerize with the prepolymer additives. The proposed project is constructed around three specific aims: 1) water-compatible monomers as alternatives to or in addition to HEMA will be developed as a means to better maintain homogeneity and high crosslink densities throughout adhesive resins; 2) the positive preliminary results with nanogel-modified adhesives will be extended into water-dispersible reactive nanogels that provide enhanced structural homogeneity and stability while introducing components that cannot be dispersed in water as free monomers; and 3) micro/nano-mechanical property characterization coupled with imaging of the adhesive layer and interfaces will be collectively used as an analytical tool to better understand structure and properties associated with the interaction between dentin and the adhesive resin in existing materials as well as the advanced adhesives proposed here. We expect to correlate the stabilization of the adhesive resin phase with collagen protection strategies that include collagen crosslinking, anti-bacterial activity and MMP-inhibiting properties based on the non-migrating nanogel platform. The application will provide an improved understanding of the strengths and weaknesses of existing adhesive systems, while developing new materials that address the significant current problems of structural stability and durability within the adhesive and hybrid layers of bonded dental restorations.