Improved Resin Bonded Dental Restoratives Based on Nanogel-modified Adhesives

基于纳米凝胶改性粘合剂的改进树脂粘合牙科修复体

• 批准号: 7830180
• 负责人: JEFFREY W. STANSBURY
• 金额: $ 44.63万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7830180
• 关键词: Address; Adhesives; Affect; Affinity; Area; Basic Science; Binding Sites; Biocompatible Materials; Chemical Engineering; Chemistry; Clinical; Collagen Fibril; Colorado; Composite Dental Resin; Dental; Dental Amalgam; Dental Bonding; Dental Enamel; Dental Materials; Dental caries; Dentin; Dentists; Deterioration; Development; Drug Formulations; Engineering; Environment; Esthetics; Exposure to; Extravasation; Failure; Generic Drugs; Goals; Grant; Healthcare Systems; Hydrophobicity; Legal patent; Link; Mechanics; Modeling; NanoGel; National Institute of Dental and Craniofacial Research; Nature; One-Step dentin bonding system; Oral; Oral health; Outcome; Patients; Performance; Plant Resins; Polymers; Population; Procedures; Property; Recruitment Activity; Research; Research Design; Resistance; Route; Solubility; Solvents; Staging; Staining method; Stains; Stress; Structure; Surface; System; Techniques; Technology; Testing; Time; Tooth structure; United States National Institutes of Health; Universities; Viscosity; Visit; Water; Water Softening; Work; aqueous; base; dental adhesive; design; evaporation; health care delivery; health science research; improved; innovation; microleakage; monomer; nanoparticle; nanoscale; new technology; novel; particle; polymerization; polymerization shrinkage; practical application; public-private partnership; response; restoration; restorative composite; restorative dentistry; restorative treatment; seal

DESCRIPTION (provided by applicant): This application addresses the broad Challenge Area (13) Smart Biomaterials - Theranostics and the specific Challenge Topic, 13-DE-102: Dental Resin Composites and Caries. With a majority of the more than 100,000 million dental restorative treatments performed in the US each year involving the placement of resin-bonded composite materials, and the observation from NIH/NIDCR that a large portion of a dentist's time is consumed with replacing these restorations, there is a clear need for materials with improved clinical performance. Composite restoratives not only hold an esthetic advantage over dental amalgams, but they offer a means to adhesively bond the restoration to dentin and enamel. However, due to polymerization shrinkage stresses that challenge this critical interface from the time of placement and a well-recognized weakening of the hydrophilic adhesive layer with prolonged exposure to the aqueous oral environment, a strong, intact margin can not currently be reliably obtained. This situation is being exacerbated by the shift towards self-etching one-step adhesives which while providing greater convenience to the practitioner, have proven to be even less reliable than the two-step etch and rinse adhesive systems. Since a high percentage of the problems in restorations requiring replacement are linked to marginal degradation, marginal staining and secondary caries formed at the margins, this appears to be great need for a substantially improved dental adhesive that can offer significantly greater initial strength and most importantly, the retention of that strength and sealing ability long term in the oral environment. A highly versatile technique has been developed recently for preparing nano- scale (5 - 100 nm) polymeric particles with control over branching, chemistry and reactive site placement. These reactive nanogels can be dispersed readily in high concentration in secondary monomers which then infiltrate and copolymerize with the prepolymer additives. This approach has provided dramatic reductions in polymerization shrinkage and stress, as well as a demonstrated ability to improve the strength of a model dental adhesive resin and then maintain that strength after complete water equilibration. There is no reasonable alternative to the use of hydrophilic monomers in dental adhesive materials since these resins must be able to penetrate well into the dentinal tubules and demineralized dentin which always retains significant moisture content. The nanogel particles can be designed to be moderately to extremely hydrophobic while also providing a high modulus network structure that has little effect on viscosity of the matrix monomer. The nanogel surface, which includes polymerizable groups to covalently attach to the matrix polymer, can also be modified with a hydrophilic shell that allows great affinity for the matrix monomer as well as the dentin substrate. The proposed project would validate the positive preliminary results and within two years, it can be expected that this new technology could be generically incorporated in to a wide variety of traditional dental adhesive materials with the result that stronger, more reliable bonded restorations could be available. There are over 100 million dental restorations placed in the US each year and most of these are resin-bonded composite materials which have good initial strength and esthetics but also a high failure/replacement rate. A primary reason for these revisions is the deterioration of the adhesive integrity which allows bacterial leakage, staining, and potentially the onset of new decay in the compromised tooth. Because of the very large numbers, the predicted significant improvements in adhesive strength and long-term reliability will generate a substantial return in fewer patient visits and expensive replacement procedures as well as improved overall oral health.

描述（由申请人提供）：此申请介绍了广泛的挑战领域（13）智能生物材料 - Theranostics和特定挑战主题，13-DE-102：牙科树脂复合材料和龋齿。每年在美国进行的超过1亿牙科修复治疗中的大部分涉及树脂键合复合材料的放置，以及NIH/NIDCR的观察结果表明，牙医的大部分时间都被消耗掉了牙医的大部分时间，以取代这些修复体，显然需要改善临床表现的材料。复合恢复不仅具有比牙科合干剂具有审美优势，而且还提供了一种将恢复与牙本质和搪瓷的粘合性粘合的手段。然而，由于聚合收缩应力，从放置时间开始挑战了这种关键界面，并且良好地认识到亲水性粘合剂层的弱化，并且长时间暴露于水性口腔环境中，目前无法可靠地获得强，完整的边缘。通过向自我蚀刻的一步胶粘剂转变，这种情况正在加剧这种情况，尽管这为从业者提供了更大的便利性，但事实证明，这一粘合剂比两步蚀刻和冲洗胶系统的可靠性更低。由于需要更换的修复体中很大的问题与边缘降解，边缘染色和次要龋齿有关，因此在边缘形成的次要龋齿似乎非常需要大大改善的牙科粘合剂，这些牙齿粘合剂可以显着提供更大的初始强度，并且最重要的是，在这种强度和密封能力中，在Oral Oral Alaal Oral环境中的保留能力很长。最近已经开发了一种高度通用的技术，用于制备具有分支，化学和反应性位置的控制纳米尺度（5-100 nm）聚合物颗粒。这些反应性纳米凝胶可以在高浓度的次级单体中易于分散，然后浸润并与前聚合物添加剂共聚并共聚。这种方法提供了聚合收缩和应力的显着降低，以及显示出改善模型牙齿粘合剂树脂强度的能力，然后在完全水平的水平后保持该强度。在牙科粘合剂材料中使用亲水性单体没有合理的替代方法，因为这些树脂必须能够很好地渗透到牙本质小管中和去矿化的牙本质中，该牙本质始终保留大量的水分含量。纳米凝胶颗粒可以设计为适度至极度疏水，同时还提供了高模量网络结构，该结构对基质单体的粘度几乎没有影响。纳米凝胶表面包括可与基质聚合物共同连接到基质聚合物的可聚合基团，也可以用亲水性壳进行修饰，该壳可以对基质单体和牙本质底物进行良好的亲和力。拟议的项目将验证积极的初步结果，并且可以在两年内，可以预料，这项新技术可以一致地纳入各种传统的牙科粘合剂材料中，结果可以提供更强，更可靠的更可靠的粘合修复体。每年美国都有超过1亿个牙科修复体，其中大多数是树脂键合的复合材料，具有良好的初始强度和美学，但也具有高失败/替代率。这些修订的主要原因是粘合剂完整性的恶化，该粘合剂完整性允许细菌泄漏，染色，并可能导致牙齿中新衰减的发作。由于数量很大，预计粘合强度和长期可靠性的显着改善将在较少的患者就诊和昂贵的替代程序中产生可观的回报，并改善了整体口腔健康。