Application of Nanogel-modified Resins for Improved Polymeric Dental Materials

纳米凝胶改性树脂在改进高分子牙科材料中的应用

• 批准号: 9081560
• 负责人: JEFFREY W. STANSBURY
• 金额: $ 38.25万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9081560
• 关键词: Address; Adhesions; Adhesives; Ammonium; Anti-Bacterial Agents; Bacterial Attachment Site; Binding Sites; Chemistry; Clinical; Composite Dental Resin; Composite Resins; Dental; Dental Amalgam; Dental Enamel; Dental Materials; Dentin; Dentists; Development; Equilibrium; Esthetics; Failure; Filler; Film; Formulation; Fracture; Generic Drugs; Goals; Individual; Matrix Metalloproteinases; Mechanics; Methacrylates; Modeling; Modification; Molecular Weight; NanoGel; Optics; Oral; Oral health; Oxygen; Patients; Performance; Phase; Pit and Fissure Sealants; Plant Resins; Polymers; Property; Resistance; Route; Stress; Structure; Surface; Suspension substance; Suspensions; Swelling; Techniques; Time; Viscosity; Visit; antimicrobial; bactericide; base; composite restoration; crosslink; dental resin; design; improved; interest; macromolecule; meetings; monomer; nanoscale; novel; particle; polymerization; polymerization shrinkage; polymerization stress; practical application; restoration; restorative composite; restorative dentistry; restorative treatment; seal

DESCRIPTION (provided by applicant): With a majority of the more than 100,000 million dental restorative treatments performed in the US each year involving the placement of resin-bonded composite materials, and the acknowledgement that a large portion of a dentist's time is consumed with revising and replacing these restorations, there is a clear need for materials with improved clinical performance. Composite restoratives not only hold an esthetic advantage over dental amalgams, but they offer a means to adhesively bond the restoration to dentin and enamel. However, due to polymerization shrinkage stresses that challenge this critical interface from the time of placement, a strong, intact margin can not currently be reliably obtained. A highly versatile technique has been developed recently for preparing nano-scale (5 - 100 nm) polymeric particles with control over branching, chemistry and reactive site placement. These reactive nanogels can be dispersed readily at high concentrations in secondary monomers, which then infiltrate and subsequently copolymerize with the prepolymer additives. This approach has provided substantial reductions in polymerization shrinkage and stress, as well as a demonstrated ability to improve the strength of a model dental resin and composite. The proposed project would extend the positive preliminary results into practical examples of highly filled, low stress, nanogel-modified composites for restorative applications while also developing new sealant materials that rely on interpenetrating polymer networks to achieve dramatically reduced levels of free monomer during placement. Bioactive sealants based on nanogels that display anti-bacterial and potentially MMP-inhibiting properties will also be developed and demonstrated. The application is constructed around three aims: i) fundamental studies of nanogel synthesis designed to produce well controlled nanogel structures with predictable properties with a primary focus on a balance between high nanogel contents in monomeric matrices with practically useful viscosities and optical properties; ii) application of nanogels in dental composites where greater than proportional reductions in stress, relative to the nanogel content, will be sought while also improving the fracture toughness of potentially bulk filling composites that combine high loading levels of both nanogel and novel surface-treated inorganic fillers; and iii) use of nanogels to create sealant materials with interpenetrating polymer networks that form with high conversion and a reduced sensitivity to oxygen inhibition, which means more stable materials with much less leachable compound release. The sealant material platform will be further extended to demonstrate the potential bioactivity of polymers with chemically integrated nanogels that convey bactericidal and MMP- inhibition properties.

描述（由申请人提供）：每年在美国进行的超过1亿个牙科修复治疗中的大部分涉及树脂键合复合材料的放置，并且承认牙医的大部分时间都可以通过修订和更换这些修复剂来进行修订和更换这些材料，以提高临床诊所的材料。复合恢复不仅具有比牙科合干剂具有审美优势，而且还提供了一种将恢复与牙本质和搪瓷的粘合性粘合的手段。然而，由于聚合收缩应力从放置时开始挑战这种关键界面，目前无法可靠地获得强，完整的边缘。最近已经开发了一种高度通用的技术，用于准备纳米级（5-100 nm）聚合物颗粒，具有对分支，化学和反应性位置的控制。这些反应性纳米凝胶可以在高浓度的次级单体中易于分散，然后浸润并随后与前聚合物添加剂共聚。这种方法可大大减少聚合收缩和压力，并显示出提高模型牙齿树脂和复合材料强度的能力。拟议的项目将将积极的初步结果扩展到高度填充，低压力，纳米凝胶修饰的复合材料的实际示例中，以恢复应用，同时还开发了依赖于互穿聚合物网络的新密封剂材料，以大大降低放置过程中自由单体的水平。还将开发和证明基于表现出抗细菌和潜在抑制MMP抑制特性的纳米凝胶的生物活性密封剂。该应用是围绕三个目的构建的：i）纳米凝胶合成的基本研究，旨在产生具有可预测性能的良好控制纳米凝胶结构，主要重点是单体矩阵中高纳米凝胶含量之间的平衡，其单体矩阵实际上具有有用的粘度性和光学特性； ii）纳米凝胶的应用 将寻求相对于纳米凝胶含量而大于比例减轻应力的牙科复合材料，同时还可以改善潜在的散装填充复合材料的骨折韧性，这些块质量结合了纳米凝胶和新型表面处理的无机填充物的高负载水平； iii）使用纳米凝胶创建具有互穿的聚合物网络的密封剂材料，这些材料形成高转化率，对氧气抑制的敏感性降低，这意味着更稳定的材料具有较少可渗透的化合物释放的材料。密封剂材料平台将进一步扩展，以证明聚合物与化学整合的纳米凝胶的潜在生物活性性，这些纳米凝聚剂传达杀菌性和MMP抑制特性。