Application of Nanogel-modified Resins for Improved Polymeric Dental Materials

纳米凝胶改性树脂在改进高分子牙科材料中的应用

• 批准号: 9081560
• 负责人: JEFFREY W. STANSBURY
• 金额: $ 38.25万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9081560
• 关键词: Address; Adhesions; Adhesives; Ammonium; Anti-Bacterial Agents; Bacterial Attachment Site; Binding Sites; Chemistry; Clinical; Composite Dental Resin; Composite Resins; Dental; Dental Amalgam; Dental Enamel; Dental Materials; Dentin; Dentists; Development; Equilibrium; Esthetics; Failure; Filler; Film; Formulation; Fracture; Generic Drugs; Goals; Individual; Matrix Metalloproteinases; Mechanics; Methacrylates; Modeling; Modification; Molecular Weight; NanoGel; Optics; Oral; Oral health; Oxygen; Patients; Performance; Phase; Pit and Fissure Sealants; Plant Resins; Polymers; Property; Resistance; Route; Stress; Structure; Surface; Suspension substance; Suspensions; Swelling; Techniques; Time; Viscosity; Visit; antimicrobial; bactericide; base; composite restoration; crosslink; dental resin; design; improved; interest; macromolecule; meetings; monomer; nanoscale; novel; particle; polymerization; polymerization shrinkage; polymerization stress; practical application; restoration; restorative composite; restorative dentistry; restorative treatment; seal

DESCRIPTION (provided by applicant): With a majority of the more than 100,000 million dental restorative treatments performed in the US each year involving the placement of resin-bonded composite materials, and the acknowledgement that a large portion of a dentist's time is consumed with revising and replacing these restorations, there is a clear need for materials with improved clinical performance. Composite restoratives not only hold an esthetic advantage over dental amalgams, but they offer a means to adhesively bond the restoration to dentin and enamel. However, due to polymerization shrinkage stresses that challenge this critical interface from the time of placement, a strong, intact margin can not currently be reliably obtained. A highly versatile technique has been developed recently for preparing nano-scale (5 - 100 nm) polymeric particles with control over branching, chemistry and reactive site placement. These reactive nanogels can be dispersed readily at high concentrations in secondary monomers, which then infiltrate and subsequently copolymerize with the prepolymer additives. This approach has provided substantial reductions in polymerization shrinkage and stress, as well as a demonstrated ability to improve the strength of a model dental resin and composite. The proposed project would extend the positive preliminary results into practical examples of highly filled, low stress, nanogel-modified composites for restorative applications while also developing new sealant materials that rely on interpenetrating polymer networks to achieve dramatically reduced levels of free monomer during placement. Bioactive sealants based on nanogels that display anti-bacterial and potentially MMP-inhibiting properties will also be developed and demonstrated. The application is constructed around three aims: i) fundamental studies of nanogel synthesis designed to produce well controlled nanogel structures with predictable properties with a primary focus on a balance between high nanogel contents in monomeric matrices with practically useful viscosities and optical properties; ii) application of nanogels in dental composites where greater than proportional reductions in stress, relative to the nanogel content, will be sought while also improving the fracture toughness of potentially bulk filling composites that combine high loading levels of both nanogel and novel surface-treated inorganic fillers; and iii) use of nanogels to create sealant materials with interpenetrating polymer networks that form with high conversion and a reduced sensitivity to oxygen inhibition, which means more stable materials with much less leachable compound release. The sealant material platform will be further extended to demonstrate the potential bioactivity of polymers with chemically integrated nanogels that convey bactericidal and MMP- inhibition properties.

描述（由申请人提供）：由于美国每年进行的超过100，000万次牙科修复治疗中的大多数涉及树脂粘结复合材料的放置，并且认识到牙医的大部分时间都用于修改和更换这些材料，因此显然需要具有改进临床性能的材料。复合材料修复剂不仅比牙科汞合金具有美学优势，而且还提供了一种将修复体与牙本质和牙釉质粘合的方法。然而，由于聚合收缩应力，挑战这个关键的接口从放置的时间，一个强大的，完整的边缘目前不能可靠地获得。最近已经开发了一种高度通用的技术用于制备纳米级（5 - 100 nm）聚合物颗粒，其具有对支化、化学和反应位点放置的控制。这些反应性纳米凝胶可以容易地以高浓度分散在第二单体中，然后渗透并随后与预聚物添加剂共聚。这种方法提供了聚合收缩和应力的显著降低，以及证明了提高模型牙科树脂和复合材料的强度的能力。拟议的项目将把积极的初步结果扩展到用于修复应用的高填充、低应力、纳米凝胶改性复合材料的实际例子中，同时还开发了依赖于互穿聚合物网络的新型密封剂材料，以在放置过程中大幅降低游离单体的水平。基于纳米凝胶的生物活性密封剂显示抗菌和潜在的MMP抑制特性也将被开发和证明。该应用围绕三个目标构建：i）纳米凝胶合成的基础研究，其设计用于产生具有可预测性质的良好控制的纳米凝胶结构，主要关注单体基质中的高纳米凝胶含量与实际有用的粘度和光学性质之间的平衡; ii）纳米凝胶在制备纳米凝胶中的应用。 牙科复合材料，其中将寻求相对于纳米凝胶含量大于成比例的应力降低，同时还改善潜在的块状填充复合材料的断裂韧性，所述复合材料组合了高负载水平的纳米凝胶和新型表面处理的无机填料两者的联合收割机;和iii）使用纳米凝胶来产生具有互穿聚合物网络的密封剂材料，所述互穿聚合物网络以高转化率和降低的对氧抑制的敏感性形成，这意味着更稳定的材料具有更少的可浸出化合物释放。密封剂材料平台将进一步扩展，以证明具有化学整合纳米凝胶的聚合物的潜在生物活性，这些纳米凝胶具有杀菌和MMP抑制特性。