Deep Tissue Magneto-Genetic Cell-Stimulation for Neuroscience and Therapy
用于神经科学和治疗的深层组织磁遗传细胞刺激
基本信息
- 批准号:8179640
- 负责人:
- 金额:$ 36.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-06 至 2015-06-30
- 项目状态:已结题
- 来源:
- 关键词:AgeAnimal BehaviorAnimalsBacterial ProteinsBehaviorBehavioralBinding ProteinsBrainBrain regionCell membraneCellsControl AnimalCoupledDeep Brain StimulationDiseaseDystoniaEngineeringFoundationsFrequenciesGeneticGenetic EngineeringGoalsHeatingHippocampus (Brain)HumanInvestigationIon ChannelKnowledgeLeadMagnetic Resonance ImagingMagnetismMajor Depressive DisorderMembraneMembrane ProteinsMental HealthMental disordersMethodsMissionMusNeuronsNeurosciencesNeurosciences ResearchParalysedParkinson DiseasePeripheralPrimary Cell CulturesProcessPublic HealthRadioResearchRodentStimulusSystemTRPV1 geneTemperatureTherapeuticTissuesTraumatic Brain InjuryWorkchronic neuropathic painheat stimulusimprovedin vivoinnovationmagnetic fieldnanoparticlenervous system disorderneural circuitneuronal circuitrynovelnovel therapeuticsresponse
项目摘要
DESCRIPTION (provided by applicant): One major goal of neuroscience is to unravel the neural circuitry and processing that control animal behaviors. A greater understanding of these systems can help in the treatment of diseases which are currently alleviated using invasive deep brain stimulation. Hence, methods for non-invasive, remote control of neuronal activity are at the top of the wish list for many neuroscientists. The goal is to develop a method to stimulate specific subsets of neurons deep in the brain without requiring a physical connection to the outside world. The objective of this proposal is to demonstrate that alternating magnetic fields may be used to stimulate neurons deep inside mammalian brains by using nanoparticles to convert the magnetic field energy into localized heat and genetically expressing a temperature sensitive ion-channel which then converts the heat stimulus into membrane depolarization. Magnetic fields interact only weakly with tissue, making them well suited for deep tissue stimulation. The fields and frequencies used will be comparable to those used in standard MRI machines. The approach contains several extremely innovative and novel concepts: (1) magnetic neuro- stimulation, (2) conversion of magnetic fields into heat to create a local and biologically detectable stimulus, (3) targeting nanoparticles to the cell membrane to achieve sub-cellular localization of the heating, and (4) genetic engineering of neurons to synthesize magnetic nanoparticles are all novel and innovative ideas. The proposed research is highly significant because it provides a method by which the relationship of neuronal circuits to animal behavior can be studied. This capability will (i) increase our understanding of normal and pathological brain function, and (ii) provide new therapeutic avenues for remote stimulations in conditions with reduced natural stimulations, such as traumatic brain injuries, Parkinson's disease, dystonia or major depression.
PUBLIC HEALTH RELEVANCE: The proposed EUREKA research is relevant to public health because a remote neuro- stimulation method will allow neuroscientists to gather the knowledge of how specific neuronal circuitry governs animal and human behavior. The results of the proposed research are expected to lead to improved treatments of ailments benefiting of specific stimulation of specific neurons or group of neurons, such as traumatic brain injuries, Parkinson's disease, and dystonia or major depression, as well as peripheral paralysis. Thus the proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will help to protect and improve mental health.
描述(申请人提供):神经科学的一个主要目标是解开控制动物行为的神经回路和处理过程。对这些系统的更多了解可以帮助治疗目前通过侵入性脑深部刺激缓解的疾病。因此,对许多神经学家来说,非侵入性、远程控制神经元活动的方法是他们最想要的。其目标是开发一种方法来刺激大脑深处的特定神经元亚群,而不需要与外部世界建立物理连接。这项提议的目的是证明交变磁场可以用来刺激哺乳动物大脑深处的神经元,方法是使用纳米颗粒将磁场能量转化为局部热,并在基因上表达温度敏感的离子通道,然后将热刺激转化为膜去极化。磁场与组织的相互作用很弱,这使得它们非常适合于深层组织刺激。所使用的磁场和频率将与标准MRI机器中使用的场和频率相当。该方法包含了几个极其创新和新颖的概念:(1)磁神经刺激,(2)将磁场转化为热以产生局部和生物可检测的刺激,(3)将纳米颗粒靶向细胞膜,实现加热的亚细胞定位,(4)利用神经元基因工程合成磁性纳米颗粒,这些都是新颖的创新想法。这项拟议的研究具有非常重要的意义,因为它提供了一种方法,可以用来研究神经元回路与动物行为的关系。这种能力将(I)增加我们对正常和病理大脑功能的了解,(Ii)为在自然刺激减少的情况下进行远程刺激提供新的治疗途径,如创伤性脑损伤、帕金森氏症、肌张力障碍或严重抑郁症。
公共卫生相关性:拟议中的尤里卡研究与公共健康相关,因为远程神经刺激方法将允许神经科学家收集关于特定神经回路如何管理动物和人类行为的知识。拟议的研究结果有望改进对特定神经元或神经元组的特定刺激受益的疾病的治疗,如创伤性脑损伤、帕金森氏症、肌张力障碍或严重抑郁症,以及外周瘫痪。因此,这项拟议的研究与NIH任务的一部分有关,即发展有助于保护和改善精神健康的基础知识。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Arnd Pralle', 18)}}的其他基金
Membrane biophysics of enterotoxin mediated immunomodulation
肠毒素介导的免疫调节的膜生物物理学
- 批准号:
8386016 - 财政年份:2012
- 资助金额:
$ 36.46万 - 项目类别:
Membrane biophysics of enterotoxin mediated immunomodulation
肠毒素介导的免疫调节的膜生物物理学
- 批准号:
8502622 - 财政年份:2012
- 资助金额:
$ 36.46万 - 项目类别:
Deep Tissue Magneto-Genetic Cell-Stimulation for Neuroscience and Therapy
用于神经科学和治疗的深层组织磁遗传细胞刺激
- 批准号:
8328888 - 财政年份:2011
- 资助金额:
$ 36.46万 - 项目类别:
Deep Tissue Magneto-Genetic Cell-Stimulation for Neuroscience and Therapy
用于神经科学和治疗的深层组织磁遗传细胞刺激
- 批准号:
8478209 - 财政年份:2011
- 资助金额:
$ 36.46万 - 项目类别:
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