Imaging Innovations for Placental Assessment in Response to Environmental Pollution

应对环境污染的胎盘评估的成像创新

• 批准号: 9077112
• 负责人: Sherin U Devaskar
• 金额: $ 425.15万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-17 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9077112
• 关键词: Accounting; Adult; Air; Air Pollution; Arteries; Biological; Biological Markers; Birth; Breathing; Chronic; Cohort Studies; Coronary Arteriosclerosis; Data; Development; Diagnosis; Discipline of obstetrics; Disease; Doppler Ultrasound; Early Diagnosis; Early treatment; Environmental Exposure; Environmental Pollution; Epidemiologic Studies; Ethnic Origin; Exposure to; Fetus; Financial compensation; First Pregnancy Trimester; Functional disorder; Future; Gold; Growth; Image; Imaging Techniques; Imaging technology; Industry; Interdisciplinary Study; Location; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Maternal Age; Measurement; Measures; Modeling; Mothers; Motion; Motor Vehicles; Neonatal; Normalcy; Outcome; Pathology; Perfusion; Placenta; Placenta Diseases; Placental Insufficiency; Pollution; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Premature Labor; Prevention strategy; Preventive; Race; Radial; Recruitment Activity; Research; Resolution; Rest; Risk; Risk Factors; Scanning; Sensitivity and Specificity; Socioeconomic Status; Spin Labels; Staging; Structure; Technology; Testing; Third Pregnancy Trimester; Time; Tissues; Toxic Environmental Substances; Toxin; Translating; Ultrasonography; Weight; base; clinical decision-making; cohort; imaging modality; implantation; in vivo; infant morbidity; innovation; novel; offspring; predictive marker; predictive modeling; primary outcome; prospective; public health relevance; quantitative imaging; response; targeted treatment; trafficking

ABSTRACT/PROJECT SUMMARY Many epidemiological studies have associated exposure to traffic-derived air pollution from motor vehicles, air toxics from industry and other environmental toxins by pregnant women with measures of poor birth outcomes including preeclampsia (PE), preterm birth (PTB) and intra-uterine growth restriction (IUGR). Preeclampsia, preterm birth and IUGR, collectively known as ischemic placental disease, are strongly correlated with infant morbidity and a host of adult diseases ranging from coronary artery disease to cancer. Although it is widely believed that the pathophysiological mechanisms leading to complications of ischemic placental disease and placental insufficiency have similar biological origins, starting as early as defective placental implantation, to date there are no predictive studies that prospectively examine placental structure and/or function. The objective of this proposal is to develop and evaluate a suit of cutting-edge multi-parametric magnetic resonance imaging (mp-MRI) technologies and translate these novel placental imaging modalities to assessing the impact of environmental pollution exposure on prediction of placental insufficiency. Our central hypothesis is that chronic exposure to high rates of environmental pollution, independent of socio-economic status (SES), increases the risk of placental insufficiency due to early gestational development of adverse placental structure/function as detected by mp- MRI technological advances. To test this hypothesis, our interdisciplinary research team at UCLA will first develop non- contrast free-breathing placental mp-MRI, consisting of multi-delay pseudo-continuous arterial spin labeling (pCASL) perfusion and high-resolution multi-contrast structural MRI, which will provide accurate measures of placental perfusion and tissue microstructure (AIM 1). The novel mp-MRI techniques will be compared to the uterine artery Doppler ultrasound through pregnancy, and validated ultimately by the gold standard histological pathology and vascularity of the post-parturient placenta (AIM 2). Lastly, we will perform in-depth analyses of recruited subjects for exposure to environmental pollution and correlate their rates of exposure to extensively collected pregnancy outcomes, towards building a predictive model (AIM 3). These studies will establish the impact of environmental pollution on placental structure and function, and related pregnancy outcomes, with obstetric and neonatal practices embracing surveillance tactics based on the residential location of pregnant women and their offspring. In addition, the proposed research will establish the potential for early recognition of placental insufficiency, thereby staging future strategies of preventive and interventional therapies targeting reversal before encountering detrimental consequences.

摘要/项目摘要 许多流行病学研究与汽车的交通衍生空气污染有关 孕妇的行业和其他环境毒素，其出生结果不佳的措施包括先兆子痫 （PE），早产（PTB）和 - 局内生长限制（IUGR）。子痫前期，早产和IUGR，共同 称为缺血性胎盘疾病，与婴儿的发病率和许多成人疾病密切相关 从冠状动脉疾病到癌症。尽管广泛认为导致的病理生理机制 缺血性胎盘疾病和胎盘不足的并发症具有相似的生物学起源 有缺陷的胎盘植入，迄今为止尚无预测研究，这些研究前瞻性检查胎盘结构 和/或功能。该提案的目的是开发和评估尖端多参数磁的诉讼 共振成像（MP-MRI）技术，并将这些新颖的胎盘成像方式转化为评估影响 胎盘不足预测的环境污染暴露。我们的中心假设是慢性 暴露于与社会经济地位（SES）无关的高环境污染发生率，增加了 由于MP-检测到的不良胎盘结构/功能的早期妊娠发育引起的胎盘不足 MRI技术进步。为了检验这一假设，我们在加州大学洛杉矶分校的跨学科研究团队将首先发展 对比自由呼吸的胎盘MP-MRI，由多延迟伪连续的动脉自旋标记（PCASL）组成 灌注和高分辨率多对比结构MRI，它将提供准确的胎盘灌注度量 和组织微观结构（AIM 1）。新型MP-MRI技术将与子宫动脉多普勒进行比较 超声检查怀孕，并最终通过黄金标准的组织学病理学和血管验证 聚会后胎盘（AIM 2）。最后，我们将对被招募的受试者进行深入分析以接触 环境污染，并将其暴露率与广泛收集的怀孕结局相关联 建立预测模型（AIM 3）。这些研究将确定环境污染对胎盘的影响 结构和功能以及相关的怀孕结局，具有产科和新生儿的实践 基于孕妇及其后代的住宅位置的策略。此外，拟议的研究将 确定早期认识胎盘不足的潜力，从而颁布未来的预防策略和 介入的介入疗法针对逆转之前，遇到有害后果。

项目成果

A Description of the Imaging Innovations for Placental Assessment in Response to Environmental Pollution Study.

环境污染研究中胎盘评估成像创新的描述。

• DOI: 10.1055/a-1961-2059
• 发表时间: 2022
• 期刊: American journal of perinatology
• 影响因子: 2
• 作者: Janzen,Carla;Lei,MargaridaYY;Lee,BrianR;Vangala,Sitaram;DelRosario,Irish;Meng,Qi;Ritz,Beate;Liu,Jonathan;Jerrett,Michael;Chanlaw,Teresa;Choi,Sarah;Aliabadi,Arya;Fortes,PreciousAnn;Sullivan,PeggyS;Murphy,Aisling;Vecchio,
• 通讯作者: Vecchio,

Human Placenta Blood Flow During Early Gestation With Pseudocontinuous Arterial Spin Labeling MRI.

• DOI: 10.1002/jmri.26944
• 发表时间: 2020-04
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Liu D;Shao X;Danyalov A;Chanlaw T;Masamed R;Wang DJJ;Janzen C;Devaskar SU;Sung K
• 通讯作者: Sung K

The Role of Epithelial to Mesenchymal Transition in Human Amniotic Membrane Rupture.

• DOI: 10.1210/jc.2016-3150
• 发表时间: 2017-04-01
• 期刊: The Journal of clinical endocrinology and metabolism
• 作者: Janzen C;Sen S;Lei MY;Gagliardi de Assumpcao M;Challis J;Chaudhuri G
• 通讯作者: Chaudhuri G

Characterization of Uterine Motion in Early Gestation Using MRI-Based Motion Tracking.

• DOI: 10.3390/diagnostics10100840
• 发表时间: 2020-10-19
• 期刊: Diagnostics (Basel, Switzerland)
• 作者: Martin T;Janzen C;Li X;Del Rosario I;Chanlaw T;Choi S;Armstrong T;Masamed R;Wu HH;Devaskar SU;Sung K
• 通讯作者: Sung K