Novel Analytical Tools for 3 Dimensional Imaging Studies on Spinal Manipulation

用于脊柱操作 3 维成像研究的新型分析工具

• 批准号: 8690774
• 负责人: NOZOMU INOUE
• 金额: $ 35.99万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8690774
• 关键词: 3-Dimensional; Basic Science; Biomechanics; Cadaver; Clinical; Clinical Research; Communities; Complementary and alternative medicine; Complex; Computer software; Data; Development; Dimensions; Disease; Effectiveness; Facet joint structure; Funding; Future; Geometry; Goals; Human; Image; Individual; Internet; Intervertebral disc structure; Lateral; Low Back Pain; Lumbar Disc Degenerative Disorder; Magnetic Resonance Imaging; Manipulative Therapies; Measurement; Measures; Medical Imaging; Methods; Modeling; Motion; Movement; Multi-Institutional Clinical Trial; Musculoskeletal Diseases; Outcome; Patients; Positioning Attribute; Principal Investigator; Program Research Project Grants; Public Domains; Research Design; Research Institute; Research Personnel; Resources; Rotation; Sample Size; Specimen; Spinal; Spinal Canal; Spinal Manipulation; Structure; System; Techniques; Technology; Therapeutic Studies; Translating; United States National Institutes of Health; Vertebral column; analytical method; analytical tool; base; clinical research site; economic impact; in vivo; kinematics; ligamentum flavum; neurophysiology; novel; programs; relating to nervous system; socioeconomics; soft tissue; three-dimensional modeling; tool; user friendly software; validation studies; web site

DESCRIPTION (provided by applicant): The overall goals of the proposed project are to translate analytical techniques developed in the field of basic science spine biomechanics to clinical studies for better understanding of the effects of spinal manipulative therapy on low back pain The specific aims of the proposed project are: (1a) To develop an analytical tool for facet kinematics analysis using 3D CT/MRI models and to validate it with cadaveric specimens, (1b) To validate an analytical tool to measure facet gap space using cadaveric specimen-specific 3D CT/MRI models, (2) To develop a novel analytical tool to measure 3D dimensions of the neural foramen and canal and validate the accuracy of these measurements using human cadaver specimens, and (3) To integrate these new and other existing standalone analytical tools into one user-friendly software package, to be made freely available on the web to investigators of large, multi-site clinical imaging studies on spinal manipulative therapies and the research community overall. New analytical tools for facet kinematics using 3D CT/MRI models and facet-based coordinate systems will be developed. A new method for 3D foramen and spinal canal analysis will be developed using a CT/MR combined 3D model. State-of-the-art technologies, which have been developed for spine biomechanics, will also be adapted for clinical studies on spinal manipulation. The analyses will include: 3D spinal alignment, 3D kinematics of the spinal motion segment during flexion, extension, lateral bending and axial rotation. These analyses will be helpful to understand the relationship between spinal structure and function and changes in spinal structure and movement before and after spinal manipulation. The new techniques to be developed in the proposed project will be validated using cadaveric specimens, and data on the accuracy of individual techniques will be provided for rigorous studies on spinal manipulation. The baseline information will be used for power analyses to assess sample size for future study designs. The analytical methods to be developed and adapted for the studies on effects of spinal manipulation will be integrated in one software package so that even the investigators who are not familiar with mathematical analyses can use these analytical methods. The software package will be released to the public domain through a dedicated website. The outcomes from the proposed study are expected to be equally effective for evaluating other forms of complementary and alternative medicine (CAM) for other musculoskeletal disorders.

描述(申请人提供)：计划的总体目标是将基础科学脊柱生物力学领域发展的分析技术转化为临床研究，以更好地了解脊柱手法疗法对腰背的影响。 本项目的具体目标是：(A)开发一种使用3D CT/MRI模型进行小关节运动学分析的分析工具，并用身体标本进行验证；(1b)验证一种使用身体标本专用的3D CT/MRI模型测量小关节间隙的分析工具；(2)开发一种新的分析工具，以测量神经孔和神经管的三维尺寸，并使用人体身体标本验证这些测量的准确性；以及(3)将这些新的和其他现有的独立分析工具集成到一个用户友好的软件包中，供大型、脊柱手法疗法和整个研究界的多点临床影像研究。将开发使用3D CT/MRI模型和基于小平面的坐标系的新的小平面运动学分析工具。利用CT/MR结合的3D模型，将开发一种新的3D孔道和椎管分析方法。为脊柱生物力学开发的最先进技术也将适用于脊柱手法的临床研究。分析内容包括：脊柱三维对齐，脊柱前屈、后伸、侧弯和轴向旋转过程中脊柱运动节段的三维运动学。这些分析将有助于了解脊柱手法前后脊柱结构和功能的关系以及脊柱结构和运动的变化。将在拟议的项目中开发的新技术将使用身体标本进行验证，并将为脊柱手法的严格研究提供关于个别技术准确性的数据。基线信息将用于功率分析，以评估未来研究设计的样本量。为研究脊柱手法的效果而开发和调整的分析方法将被整合到一个软件包中，以便即使是不熟悉数学分析的研究人员也可以使用这些分析方法。该软件包将通过一个专门的网站向公共领域发布。这项拟议研究的结果预计将同样有效地评估其他形式的补充和替代医学(CAM)治疗其他肌肉骨骼疾病。